Jane Gitschier speaks to Edwin Southern, inventor of the Southern blot used to transfer DNA from gels onto nitrocellulose paper. One of the first to sequence eukaryotic DNA and to appreciate the genetic architecture of satellite DNAs, he was also a strong and productive proponent of physical mapping of the human genome as a complement to the genetic map.
To investigate the pathological mechanism of polyalanine (PA) disorders, these authors generated a mouse model of X-linked Hypopituitarism, a disease caused by PA expansion in the SOX3 protein.
These authors employed an outbred Saccharomyces cerevisiae model to identify quantitative trait loci that control replicative lifespan, and find that calorie restriction conditions also reduce rDNA replication, potentially promoting longevity by the same mechanism.
These authors demonstrated that the miR-191/425 cluster, by reducing the expression of an extensive network of genes, has a fundamental impact on cancer initiation and progression of breast cancer cells.
Browse Articles in the Genetics and Genomics Subject Area
PLOS Biology; PLOS Medicine; PLOS Computational Biology; PLOS Genetics; PLOS Pathogens; PLOS ONE; PLOS Neglected Tropical DiseasesBrowse Article Collections
PLOS Biology; PLOS Medicine; PLOS Computational Biology; PLOS Genetics; PLOS Pathogens; PLOS ONE; PLOS Neglected Tropical DiseasesPLOS Genetics is a peer-reviewed, open-access journal that reflects the full breadth and interdisciplinary nature of genetics and genomics research by publishing outstanding original contributions in all areas of biology.