Disease Description:

Multiple sclerosis (MS) is a chronic disorder affecting movement, sensation, and bodily functions. It is caused by destroying the layer (called myelin) of cells surrounding neurons in the brain and spinal cord. Myelin helps electrical signals pass quickly and smoothly between the brain and the rest of the body. When the myelin is destroyed, nerve messages are sent more slowly and less efficiently. The symptoms of MS occur when the brain and spinal cord nerves no longer communicate properly with other parts of the body. MS causes a wide variety of symptoms and can affect vision, balance, strength, sensation, coordination, and bodily functions.

General Study Procedures:

The research studies listed below are currently open for enrollment for adult subjects. These may involve primary screening and neuroimaging procedures; administering various combinations of drugs, and testing cognitive function. Please see the links for the procedures and eligibility criteria for specific studies. There is no cost for participation or for any tests associated with the research.

Studies Actively Recruiting Patients:

89-N-0045: Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)

05-N-0063: Biomarkers in Multiple Sclerosis

07-N-0092: Brain Peripheral Benzodiazepine Receptors in Patients With Multiple Sclerosis

09-N-0032: Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System

09-N-0197: Double Blind Placebo-Controlled Phase I/II Clinical Trial of Idebenone in Patients With Primary Progressive Multiple Sclerosis

10-N-0125: Investigating Mechanism of Action of DAC HYP in the Treatment of High-Inflammatory Multiple Sclerosis (MS)

10-N-0212: Double Blind Combination of Rituximab by Intravenous and Intrathecal Injection Versus Placebo in Patients With Low-Inflammatory Secondary Progressive Multiple Sclerosis (RIVITaLISe)

For more information about participating in these studies, please contact :
For protocol 89-N-0045 or 07-N-0092 or 09-N-0197 or 09-N-0032 Joan Ohayon, CRNP NINDS, NIB Bldg. 10, Room 5C101 10 Center Drive, MSC 1400 Bethesda, MD 20892-1400 Tel: 301-496-0064 Email: ohayonj@ninds.nih.gov
For protocol 05-N-0063 Helen Griffith, R.N. NINDS, NIB Bldg. 10, Room 5C101 10 Center Drive, MSC 1400 Bethesda, MD 20892-1400 Tel: 301-496-0064 Email: hgriffith@mail.nih.gov
For protocol 10-N-0125 or 10-N-0212 Kaylan Fenton Bldg. 10, Room 5C101 10 Center Dr., MSC 1400 Bethesda, MD 20892-1400 Tel: 301-496-0064 Email: fentonk@ninds.nih.gov
or
Patient Recruitment and Public Liaison Office toll-free at: 1-800-411-1222 TTY: 1-866-411-1010

For more information on Multiple Sclerosis:

http://www.ninds.nih.gov/disorders/multiple_sclerosis/multiple_sclerosis.htm

Related Links:

ClinicalTrials.gov