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E-Newsletter7th Edition: May 6, 2004IN THIS ISSUE: 1) New Funding Opportunities NEW FUNDING OPPORTUNITIES NIDCR Program Announcements NIDCR Small Research Grants for Data Analysis and Statistical
Methodology (R03) NIH RoadmapRequest for Applications Molecular Libraries Screening Centers Network (MLSCN) Good Response Received to NIH Multidisciplinary Clinical Research
Career Development Program TRAINING OPPORTUNITIESDental Applications Increase for Howard Hughes Research Training Fellowship The Howard Hughes Research Training Fellowship Students Selected for NIDCR Summer Dental Student AwardThe NIDCR Summer Dental Student Award is an eight-week program designed to expose dental students to the latest advances in oral health research. Students are assigned a research mentor based on stated research interests and learn state-of-the-art technologies to improve the prevention, diagnosis, and therapy of oral diseases. Eight dental students were selected from across the country to participate this summer. Schools represented include: the University of Maryland Baltimore College of Dental Surgery, Harvard University School of Dental Medicine, the Medical University of South Carolina College of Dental Medicine, Columbia University School of Dental and Oral Surgery, Nova Southeastern University College of Dental Medicine, the University of Connecticut School of Dental Medicine, and Temple University School of Dentistry. Further details about the program are available at: http://www.nidcr.nih.gov/research/student.asp FIC/Ellison Overseas Fellowships in Global Health and Clinical Research Available The Fogarty International Center (FIC), with support from the
Ellison Medical Foundation, is offering a one-year clinical
research training experience for graduate level U.S. students in
the health professions, including dentistry. The fellowship is an
opportunity for highly motivated individuals to receive mentored
research training at top-ranked NIH-funded research centers in
developing countries. The countries include Botswana, Brazil,
Haiti, India, Kenya, Mali, Peru, South Africa, Thailand, Uganda,
and Zambia. To access specific information about the program,
please visit: Training CD Will Soon be AvailableNIDCR has developed a CD entitled "Facing Your Future: Research Training and Career Development Opportunities," which is aimed at groups ranging from high school students to independent scientists. Designed to replace written publications that quickly go out-of- date, the CD links potential research trainees directly to relevant training information on the NIDCR web site. The CD begins with a fast-paced introduction set to music that describes different facets of oral health and ends by linking users to the training section of the NIDCR web site. The NIDCR Office of Communications and Health Education is now testing the CD with members of the various target audiences. Once the CD is finalized, NIDCR will distribute it at conferences and other training-related events and activities. NIH NEWSNIH To Hold Regional Seminars on Program Funding and Grants Administration The NIH Office of Extramural Research (OER) sponsors semiannual NIH Regional Seminars on Program Funding and Grants. These seminars are intended to help demystify the application and review process, clarify Federal regulations and policies, and highlight current areas of special interest or concern. The seminars are appropriate for grants administrators, researchers new to NIH, and graduate students. For further information, please see: http://grants2.nih.gov/grants/seminars.htm NIH also sponsors several other outreach programs, including:
Office of Laboratory Animal Welfare (OLAW) workshops on
implementing the Public Health Service Policy on Animal Welfare
Education: Office for Human Research Protections workshops on the responsibilities of researchers, Institutional Review Boards, and institutional officials for the protection of human subjects in research. The workshops are open to everyone with an interest in research involving human subjects: http://ohrp.osophs.dhhs.gov/wrkshp.htm NIH Small Business Research Conferences addressing the needs of small business researchers interested in the SBIR/STTR programs: http://grants.nih.gov/grants/funding/sbir.htm#conferences Office of Research Integrity Workshops and Conferences to promote
scientific integrity: NIH Institutes to Develop a Trans-NIH Blueprint for Brain Research NIH Director Elias Zerhouni has asked a group of NIH Institutes, including the NIDCR, to work together over the next few months to develop a trans-NIH blueprint for brain research. The primary goal of the blueprint is to organize and coordinate neuroscience resources and objectives among the institutes. The blueprint likely will target three areas: infrastructure, technology development, and common research themes. In addition to the NIDCR, the institutes that will help develop the brain research blueprint are the National Institute of Neurological Disorders and Stroke, the National Institute of Mental Health, the National Institute on Drug Abuse, the National Institute on Deafness and Other Communication Disorders, the National Institute on Alcohol Abuse and Alcoholism, the National Eye Institute, the National Institute on Aging, the National Institute of General Medical Sciences, and the National Institute of Child Health and Human Development. Blue Ribbon Panel Issues Conflict of Interest Policy Recommendations The NIH Director established a working group of the Advisory Committee to the Director to study the issues surrounding NIH researchers' consulting with outside groups. The working group, known as the NIH Blue Ribbon Panel on Conflict of Interest Policies, is led by Bruce Alberts, President of the National Academy of Sciences, and Norman R. Augustine, Chairman of the Executive Committee of the Lockheed Martin Corporation. The charge of the Panel was to review and make recommendations for improving the existing rules and procedures under which NIH currently operates regarding real and apparent financial conflict of interest of NIH staff and requirements and policies for the reporting of NIH staff's financial interests. The panel provided recommendations on May 6 to the Advisory Committee to the Director. The report of the panel is available at: http://www.nih.gov/about/ethics_COI_panelreport.htm NEW ORAL HEALTH REPORTS AND SURVEYS RELEASEDNew AHRQ Report On Periodontitis Therapy Is Available Some antimicrobials show promise as adjunctive therapies to scaling and root-planing for treating non-aggressive chronic periodontitis in patients without other conditions such as diabetes or immune deficiency, according to a new systematic literature review prepared by the Agency for Healthcare Research and Quality (AHRQ) RTI-University of North Carolina Evidence-based Practice Center. The evidence-based report was funded by the NIDCR. The report, entitled "Effectiveness of Antimicrobial Adjuncts to Scaling and Root-Planing Therapy for Periodontitis," is the fourth and final report in a series of systematic reviews of published evidence- based literature on dental-related topics for NIDCR. The report is available online at: http://www.ahrq.gov/clinic/epcsums/periosum.htm WHO Releases New Report on Global Problem of Oral Diseases The World Health Organization (WHO) has released a report showing that dental caries, periodontitis, and oral and pharyngeal cancers are a global health problem in both industrialized and developing countries, especially among poorer communities. In announcing the findings, WHO said that an estimated five billion people worldwide had experienced dental caries. The report is available on the WHO web site at: http://www.who.int/oral_health/media/en/orh_report03_en.pdf WHO Publishes Report on Craniofacial Anomalies In 2000, NIDCR began a partnership with the World Health
Organization (WHO) to launch the International Collaborative
Research on Craniofacial Anomalies Project. The partnership
promotes collaboration in craniofacial anomalies research (CFA) and
aims to develop global consensus on CFA research directions. So
far, the project has yielded several products:
*A WHO report on "Global Strategies to Reduce the Healthcare Burden A report from a meeting held in Bauru, Brazil addressing the
implementation of a centralized global registry of craniofacial
birth defects:
*http://www.who.int/genomics/publications/en/ NHANES III Data ReleasedThe Centers for Disease Control and Prevention/National Center for Health Statistics has announced the release of the Oral Health Examination Data from the National Health and Nutrition Examination Survey (NHANES) for survey years 1999-2000. The data are being released as three datasets: Oral Health (Dentition Section), Oral Health (Periodontal Section), and Oral Health (Recommendation of Care/Referral Section). The datasets and documentation may be found on the NHANES web site at: http://www.cdc.gov/nchs/about/major/nhanes/NHANES99_00.htm New Survey Information Available on Dental, Oral and Craniofacial Data Resource Center (DRC) Web Site The NIDCR/CDC Dental, Oral and Craniofacial Data Resource Center recently posted to its web site the March 2004 release of the Catalog of Surveys and Archive of Procedures Related to Oral Health. The release contains new survey entries along with updated survey information of entries already contained in the catalog. It is available free of charge on CD-ROM. To order the Catalog/Archive or view the March 2004 release, go to: http://drc.nidcr.nih.gov/catalog.htm SCIENCE ADVANCES Animal Studies Show Promise Treating Severe Chronic Pain
See NIDCR news release at: Periodontal Disease: Early Progress Reported in Tissue Engineering
See NIDCR news release at: Scientists Identify Candidate Genes in Tumor Regression
See NIDCR news release at: PERSONNEL NEWSBernard A. Schwetz to Head Office for Human Research Protections HHS Secretary Tommy G. Thompson has announced the appointment of Bernard A. Schwetz, D.V.M., Ph.D., as director of the HHS Office for Human Research Protections (OHRP). Dr. Schwetz had served as acting director of the office since February 2003. OHRP leads the department's efforts to ensure the protection of human subjects in research. The office monitors programs at more than 10,000 HHS- funded universities, hospitals and other medical and behavioral research institutions in the United States and abroad. Prior to joining the OHRP, Dr. Schwetz served as the senior advisor for science at the Food and Drug Administration and as a distinguished scientist at the University of Maryland. He was the acting principal deputy commissioner of the FDA from January 2001 to February 2002, and before that was the agency's acting deputy commissioner. He also chaired the FDA's Institutional Review Board for the protection of human subjects. Dr. Silvio Gutkind Wins IADR Award Dr. J. Silvio Gutkind, Chief of the NIDCR Oral and Pharyngeal Cancer Branch, is the 2004 recipient of the Oral Medicine and Pathology Research Award from the International Association for Dental Research. Dr. Gutkind's research addresses the molecular basis of cancer through studies of normal and aberrant functions of molecules involved in the transduction of proliferative signals. His laboratory has made seminal contributions to the field and has helped elucidate some of the basic molecular mechanisms whereby cell-surface receptors regulate the nuclear expression of growth- promoting genes. Dr. Gutkind also heads a multi-institutional effort aimed at elucidating the molecular mechanisms that contribute to the evolution of squamous cell carcinomas and how to use this knowledge to develop molecular markers of disease progression and novel therapeutic approaches in oral malignancies. The IADR Oral Medicine and Pathology Award is supported by Sunstar Butler and consists of a cash prize and a plaque. It is one of 15 Distinguished Scientist Awards given annually by the IADR. Dr. David Sidransky Wins American Association for Cancer Research (AACR) Award NIDCR grantee David Sidransky, Director of Head and Neck Cancer Research and a professor at Johns Hopkins University, received the 2004 AACR-Richard and Hinda Rosenthal Foundation Award. Dr. Sidranksy was honored for his pioneering translational research in molecular oncology. He has made major strides in elucidating the molecular pathogenesis of smoking-related cancers of the aerodigestive tracts. His work has led to the definition of molecular markers for the early detection of cancer, which have tremendous potential for widespread applications as highly accurate screening tests for cancers of the head, neck, lung, and bladder. The Rosenthal Foundation established this award to recognize research that has made, or gives the promise of soon making, a notable contribution to improved clinical care in the field of cancer. We encourage you to distribute this newsletter to any colleagues
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