Cellular Systems Cluster

PROGRAM GUIDELINES

Apply to PD 04-1114 as follows:

For full proposals submitted via FastLane: standard Grant Proposal Guidelines apply.
For full proposals submitted via Grants.gov: NSF Grants.gov Application Guide; A Guide for the Preparation and Submission of NSF Applications via Grants.gov Guidelines apply (Note: The NSF Grants.gov Application Guide is available on the Grants.gov website and on the NSF website at: http://www.nsf.gov/publications/pub_summ.jsp?ods_key=grantsgovguide)

Please be advised that the NSF Proposal & Award Policies & Procedures Guide (PAPPG) includes revised guidelines to implement the mentoring provisions of the America COMPETES Act (ACA) (Pub. L. No. 110-69, Aug. 9, 2007.) As specified in the ACA, each proposal that requests funding to support postdoctoral researchers must include a description of the mentoring activities that will be provided for such individuals. Proposals that do not comply with this requirement will be returned without review (see the PAPP Guide Part I: Grant Proposal Guide Chapter II for further information about the implementation of this new requirement).

DUE DATES

Full Proposal Target Date:  July 12, 2009

July 12, Annually Thereafter

Full Proposal Target Date:  January 12, 2010

January 12, Annually Thereafter

SYNOPSIS

The Cellular Systems Cluster, one of three thematic areas within the Division of Molecular and Cellular Biosciences, supports research, across all taxa, into the structure and organization of cells and the dynamics of cellular processes.  Cell Biology is at a juncture where powerful new techniques in microscopy and biophysics (including live cell imaging, and the ability to study molecular function and behavior in the cell at high resolution, down to the single molecule level) are advancing rapidly.  At the same time, modeling and computational approaches have developed to the point where they can, in concert with accurate and informative experimental datasets, generate predictive models that can be tested experimentally. The Cellular Systems cluster is interested not only in traditional areas of cell biology (such as the organization, function, and dynamics of membranes, organelles and other subcellular compartments, and intracellular and transmembrane signal transduction mechanisms and cell-cell signaling processes) but also in the development of quantitative, theory-driven approaches to cell biology that integrate experimental studies at the molecular genetic, biochemical, biophysical, transcriptomic and proteomic levels.  Network theory (e.g., as applied to signal transduction) and molecular dynamic modeling (e.g., as applied to the structure/function relationships of cellular structures) are also of particular interest. While proposals using approaches and model systems traditional in the field of cell biology are welcome, studies focused on novel, unique approaches and on non-traditional model organisms are encouraged.

Program Directors:

LaJoyce H. Debro. Cellular organization and signal transduction in microbial cells, including inter- and intracellular targeting of proteins, assembly of cellular structures, interaction of microbes with the environment, cellular aspects of regulation of gene expression, and integration of research in microbiology in instruction.

Richard Rodewald. Cellular organization,compartmentation,biogenesis of organelles and regulation.

Gregory Warr. Signal transduction and cellular regulation.

Abstracts of Recent Awards Made Through This Program

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