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Comparative Effectiveness of Standard Antibiotic Treatment for CDI

Nonstandard Interventions to Treat CDI or Reduce the Risk of Recurrence

Knowledge Gaps and Future Research Needs (1 of 3)

What Is an Analytic Framework? A type of evidence model that links and defines clinical concepts, evidence, and populations as they relate to outcomes. Sometimes referred to as causal pathways. Alternative and related concepts are: Conceptual frameworks, Influence diagrams, Theoretical frameworks, Logic models.

What Is an Analytic Framework?

Components. Population of interest. Intervention. Linkages that demonstrate key questions. Intermediate outcomes. Ultimate health outcomes (including harms).

Components

This framework begins with a box representing “Women presenting with symptoms of OAB”, which is also labeled “Population” for the PICOTS (population, intervention, comparators, outcomes, timing, and setting) domain. An arrow labeled “History/Clinical exam” leads from this box to a diamond labeled “Testing.” Arrows lead to a box labeled “Further evaluation” and another labeled “None.” Arrows lead from each box to a diamond labeled “Diagnosis.” An arrow leads from this diamond back to the “Testing” diamond. All of the boxes and diamonds listed so far are contained by a bracket labeled “Key Question 1.” An arrow leads from “Diagnosis” to another diamond labeled “Treatment Choice,” which is also labeled “Intervention” for PICOTS and Key Question 5. An arrow leads from “Treatment Choice” to a box labeled “Treatment approach.” An arrow labeled “Key Question 2 & Key Question 3” leads from “Treatment Approach” to a box containing outcomes. This box is labeled “Outcomes” for the PICOTS domain. An arrow leads from the outcomes box to the “Testing” diamond, indicating that the process can be repeated. The entire framework is framed by “Health care system” modifiers at the top, and “KQ4 Individual characteristics” at the bottom.

Sample Screening and Treatment Framework

Population of Interest. One of the essential components of an analytic framework is the population of interest. A True. B. False.

Population of Interest

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