- Secretary, Janet Napolitano
- Deputy Secretary, Jane Holl Lute
- Chief of Staff, Amy Shlossman
- Executive Secretariat, Philip A. McNamara
- General Counsel (acting), John Sandweg
- Military Advisor, Rear Admiral Fred M. Midgette
- Under Secretary, Management, Rafael Borras
- Deputy Under Secretary for Management, Chris Cummiskey
- Chief Financial Officer, Peggy Sherry
- Under Secretary, National Protection & Programs Directorate, Rand Beers
- Assistant Secretary, Office of Cybersecurity and Communications (acting), Roberta Stempfley
- Assistant Secretary, Infrastructure Protection, Caitlin Durkovich
- Deputy Under Secretary, Suzanne Spaulding
- Deputy Under Secretary for Cybersecurity, Mark Weatherford
- Director, Federal Protective Service, L. Eric Patterson
- Director, US-VISIT Program, Robert A. Mocny
- Under Secretary, Science & Technology, Dr. Tara O'Toole
- Under Secretary, Office of Intelligence and Analysis, (Vacant)
- Assistant Secretary, Office of Policy, David Heyman
- Assistant Secretary, Office of International Affairs and Chief Diplomatic Officer, Alan Bersin
- Assistant Secretary, Private Sector Office, Douglas Smith
- Assistant Secretary, Office for State and Local Law Enforcement, Louis F. Quijas
- Assistant Secretary, Office of Policy Development, David Pressman
- Assistant Secretary, Office of Policy for Strategy, Planning, Analysis & Risk, Alan D. Cohn
- Assistant Secretary, Office of Intergovernmental Affairs, (Vacant)
- Director, U.S. Citizenship and Immigration Services, Alejandro Mayorkas
- Commandant, U.S. Coast Guard, Admiral Robert J. Papp, Jr.
- Deputy Commissioner, U.S. Customs and Border Protection, David V. Aguilar
- Director, U.S. Immigration and Customs Enforcement (ICE), John T. Morton
- Administrator, Federal Emergency Management Agency, W. Craig Fugate
- U.S. Fire Administrator, Ernest Mitchell Jr.
- Director, U.S. Secret Service, Mark J. Sullivan
- Administrator, Transportation Security Administration, John S. Pistole
- Citizenship and Immigration Services Ombudsman, Maria M. Odom
- Officer for Civil Rights & Civil Liberties (acting), Tamara Kessler
- Director of the Domestic Nuclear Detection Office (acting), Huban Gowadia
- Director, Federal Law Enforcement Training Center, Connie L. Patrick
- Assistant Secretary, Office of Health Affairs/Chief Medical Officer, Dr. Alexander Garza
- Inspector General (acting), Charles K. Edwards
- Assistant Secretary, Office of Legislative Affairs, Nelson Peacock
- Director, Operations Coordination, Richard Chavez
- Chief Privacy Officer (acting), Jonathan Cantor
- Assistant Secretary, Office of Public Affairs, (acting) Matthew Chandler
.