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"anthropometrics"

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Topic Refinement Process: UCONN/HH EPC Example (III). P—Patients with cystic fibrosis. I—Recombinant human growth hormone. C—Placebo, no therapy, another active therapy, or no control therapy. O—Pulmonary variables, anthropometrics, bone variables, IGF variables, hospitalization, bone fracture, health-related quality of life, glucose intolerance, malignancy, and mortality. T—At least 4 weeks of therapy with recombinant human growth hormone. S—Outpatient primary care, endocrine, or cystic fibrosis clinic.

Topic Refinement Process: UCONN/HH EPC Example (III)

Topic Refinement Process: UCONN/HH EPC Example (VII). Questions for Key Informants: How different is a study including people up to 23 years of age from a study limited to 18-year-olds? Consider this given the inverse linear relationship between human growth hormone efficacy and age, as well as the delayed growth and maturation inherent in this population. How readily do you feel we can combine certain end points (e.g., lean body mass measured by different methods [DEXA, skin folds, BIA] in same units) or amino acid catabolism measures (leucine vs. glutamine)?

Topic Refinement Process: UCONN/HH EPC Example (VII)