Projects

IDENTIFICATION AND ENHANCEMENT OF SEED-BASED BIOCHEMICAL RESISTANCE IN CROPS TO AFLATOXIN PRODUCING PATHOGENS Appropriated (D)   Accession Number: 409782

AFLATOXIN CONTROL THROUGH TARGETING MECHANISMS GOVERNING AFLATOXIN BIOSYNTHESIS IN CORN AND COTTONSEED Appropriated (D)   Accession Number: 409790

SEQUENCING AND ANNOTATION OF EXPRESSED SEQUENCE TAGS FROM ASPERGILLUS FLAVUS Grant (G)   Accession Number: 411145

GENOME SEQUENCING, ANALYSIS, AND FUNCTIONAL GENOMIC STUDIES OF ASPERGILLUS FLAVUS Grant (G)   Accession Number: 412266

COMPARATIVE ANALYSIS OF GENOME ORGANIZATION BETWEEN A. FLAVUS AND A. ORYZAE Nonfunded Cooperative Agreement (N)   Accession Number: 410583

GENE NETWORKS CONTROLLING DEVELOPMENT, PATHOGENICITY AND SECONDARY METABOLISM IN ASPERGILLUS Reimbursable (R)   Accession Number: 410825

Publications

Aflatoxins - (Review Article) - (17-Jun-08)

Strategy in Prevention of Preharvest Aflatoxin Contamination in Peanuts: Aflatoxin Biosynthesis, Genetics and Genomics - (Peer Reviewed Journal) - (20-May-08)

The "omics" Tools: Genomics, Proteomics, Metabolomics for Solving the Aflatoxin Contamination Problem - (Review Article)

Bhatnagar, D., Rajasekaran, K., Payne, G.A., Brown, R.L., Yu, J., Cleveland, T.E. 2008. The "omics" Tools: Genomics, Proteomics, Metabolomics for Solving the Aflatoxin Contamination Problem. World Mycotoxin Journal. 1(1):3-12.

Genetics and Genomics of Aspergillus flavus - (Review Article) - (20-Dec-07)

Peanut gene expression profiling in developing seeds at different reproduction stages during Aspergillus parasiticus infection - (Peer Reviewed Journal)

Guo, B., Chen, X., Dang, P., Scully, B.T., Liang, X., Holbrook, C.C., Yu, J., Culbreath, A.K. 2008. Peanut gene expression profiling in developing seeds at different reproduction stages during Aspergillus parasiticus infection. BMC Developmental Biology. 8:12

Molecular Approaches to Development of Resistance to Preharvest Aflatoxin Contamination - (Book/Chapter)

Bhatnagar, D., Rajasekaran, K., Cary, J.W., Brown, R.L., Yu, J., Cleveland, T.E. 2007. Molecular Approaches to Development of Resistance to Preharvest Aflatoxin Contamination. In: Leslie, J.F., Bandyopadhyay, R., and Visconti, A. (eds.) Mycotoxins: Detection Methods, Management, Public Health, and Agricultural Trade. Wallingford, Oxfordshire, UK:CABI Publishing. p. 259-279.

Elucidation of the functional genomics of antioxidant-based inhibition of aflatoxin biosynthesis - (Peer Reviewed Journal)

Kim, J.H., Yu, J., Mahoney, N.E., Chan, K.L., Molyneux, R.J., Varga, J., Bhatnagar, D., Cleveland, T.E., Campbell, B.C. 2008. Elucidation of the functional genomics of antioxidant-based inhibition of aflatoxin biosynthesis. International Journal of Food Microbiology.122(1-2):49-60.

Genes Differentially Expressed by Aspergillus flavus Strains After Loss of Aflatoxin Production by Serial Transfers - (Abstract)

Chang, P., Wilkinson, J.R., Horn, B.W., Yu, J., Bhatnagar, D., Cleveland, T.E. 2007. Genes Differentially Expressed by Aspergillus flavus Strains After Loss of Aflatoxin Production by Serial Transfers. Multicrop Aflatoxin and Fumonisin Elimination and Fungal Genomics Workshop-The Peanut Foundation, Atlanta, GA. p. 34.

Generation of expressed sequence tags (ESTs) from cultivated peanuts for gene discovery and marker development - (Abstract)

Guo, B., Chen, X., Dang, P.M., Holbrook, Jr., C.C., Culbreath, A., Scully, B.T., Yu, J., Nierman, W.C., Cleveland, T.E. 2007. Generation of expressed sequence tags (ESTs) from cultivated peanuts for gene discovery and marker development [abstract]. Proceedings of the 2007 Annual Multi-crop Aflatoxin/Fumonisin Elimination and Fungal Genomics Workshop, October 22-24, 2007, Atlanta, GA. p. 88.

Genes Differentially Expressed by Aspergillus flavus Strains After Loss of Aflatoxin Production by Serial Transfers - (Peer Reviewed Journal)

Chang, P., Wilkinson, J.R., Horn, B.W., Yu, J., Bhatnagar, D., Cleveland, T.E. 2007. Genes differentially expressed by Aspergillus flavus strains after loss of aflatoxin production by serial transfers. Applied Microbiology and Biotechnology. 77:917-925.

Genomics of Industrial Aspergilli and Comparison with Toxigenic Relatives - (Review Article) - (15-Sep-07)

Aspergillus flavus Genomics in Controlling Aflatoxin Contamination of Food and Feed - (Peer Reviewed Journal) - (30-Aug-07)

AFLATOXIN FORMATION AND GENE EXPRESSION IN RESPONSE TO CARBON SOURCE MEDIA SHIFT IN ASPERGILLUS PARASITICUS - (Peer Reviewed Journal)

Wilkinson, J.R., Yu, J., Abbas, H.K., Scheffler, B.E., Kim, H.S., Nierman, W.C., Bhatnagar, D., Cleveland, T.E. 2007. Aflatoxin formation and gene expression in response to carbon source media shift in Aspergillus parasiticus. Journal of Food Additives & Contaminants. 24(10):1051-1060.

Analysis of aflatoxin regulatory factors in serial transfer-induced non-aflatoxigenic Aspergillus parasiticus - (Peer Reviewed Journal)

Kale, S.P., Cary, J.W., Hollis, N., Wilkinson, J.R., Bhatnagar, D., Yu, J., Cleveland, T.E., Bennett, J.W. 2007. Analysis of aflatoxin regulatory factors in serial transfer-induced non-aflatoxigenic Aspergillus parasiticus. Journal of Food Additives & Contaminants. 24(10):1061-1069.

Understanding Nonaflatoxigenicity of Aspergillus sojae: A Windfall of Aflatoxin Biosynthesis Research - (Review Article)

Chang, P.-K., Matsushima, K., Takahashi, T., Yu, J., Abe, K., Bhatnagar, D., Yuan, G., Koyama, Y., Cleveland, T.E. 2007. Understanding nonaflatoxigenicity of Aspergillus sojae: a windfall of aflatoxin biosynthesis research. Applied Microbiology and Biotechnology. 76:977-984.

Batch submission and release of 14,328 EST (expressed sequence tag) nucleotide sequences of developing peanut seeds of R5, R6, and R7 reproduction stages - (Germplasm Release)

Guo, B., Dang, P.M., Chen, X., Scully, B.T., Liang, X., Yu, J., Holbrook, Jr., C.C. 2007. Batch submission and release of 14,328 EST (expressed sequence tag) nucleotide sequences of developing peanut seeds of R5, R6, and R7 reproduction stages. GenBank, National Center for Biotechnology Information Accession No. ES702769-ES717096.

Gene Profiling for Studying the Mechanism of Aflatoxin Biosynthesis in Aspergillus flavus and A. parasiticus - (Peer Reviewed Journal)

Yu, J., Ronning, C.M., Wilkinson, J.R., Campbell, B.C., Payne, G.A., Bhatnagar, D., Cleveland, T.E., Nierman, W.C. 2007. Gene profiling for studying the mechanism of aflatoxin biosynthesis in Aspergillus flavus and A. parasiticus. Journal of Food Additives & Contaminants. 24(10):1035-1042.

Elucidation of veA Dependent Genes Associated with Aflatoxin and Sclerotial Production in Aspergillus flavus by Functional Genomics - (Peer Reviewed Journal)

Cary, J.W., OBrian, G.R., Nielsen, D.M., Nierman, W., Harris-Coward, P.Y., Yu, J., Bhatnagar, D., Cleveland, T.E., Payne, G.A., Calvo, A.M. 2007. Elucidation of veA-dependent genes associated with aflatoxin and sclerotial production in Aspergillus flavus by functional genomics. Applied Microbiology and Biotechnology. 76:1107-1118.

Identification of Aspergillus section Flavi in Maize in Northeastern China - (Peer Reviewed Journal) - (16-May-07)

What Can Comparative Genomics Tell Us About Species Concepts in the Genus Aspergillus? - (Peer Reviewed Journal)

Rokas, A., Payne, G., Fedorova, N.D., Baker, S.E., Machida, M., Yu, J., Georgianna, D.R., Dean, R.A., Bhatnagar, D., Cleveland, T.E., Wortman, J.R., Maiti, R., Joardar, V., Amedeo, P., Denning, D.W., Nierman, W.C. 2007. What Can Comparative Genomics Tell Us About Species Concepts in the Genus Aspergillus?. Studies in Mycology. 59:11-17.

Aspergillus flavus Genomics for Development of Strategies to Interrupt Aflatoxin Formation and Discovery of Fungal Enzymes for Biofuel Production - (Abstract)

Cleveland, T.E., Yu, J., Bhatnagar, D., Nierman, W.C., Payne, G.A. 2007. Aspergillus flavus Genomics for Development of Strategies to Interrupt Aflatoxin Formation and Discovery of Fungal Enzymes for Biofuel Production. Society of Industrial Microbiology Annual Meeting, July 29-August 2, 2007, Denver, CO. Abstract #S87. p. 102.

Genetic and Biochemical Control of Aflatoxigenic Fungi - (Book/Chapter)

Bhatnagar, D., Rajasekaran, K., Brown, R.L., Cary, J.W., Yu, J., Cleveland, T.E. 2007. Genetic and Biochemical Control of Aflatoxigenic Fungi. In: Wilson, C.L. (editor). Microbial Food Contamination. CRC Press. 17:395-426.

Aspergillus flavus Genomics for Controlling Aflatoxin Contamination - (Abstract) - (01-Apr-07)

Comparative Genomics in Identifying Aflatoxin Biosynthetic Genes - (Abstract) - (01-Apr-07)

Comparative Genomics of Aspergillus flavus and A. oryzae: An Early View - (Abstract) - (30-Mar-07)

Integrated Database for Functional Analysis in Aspergillus flavus - (Abstract)

Smith, C.P., Woloshuk, C.P., Keller, N.P., Yu, J., Payne, G.A. 2007. Integrated Database for Functional Analysis in Aspergillus flavus. In: Proceedings of the 24th Fungal Genetics Conference and the 4th International Aspergillus Meeting, March 18-25, 2007, Asilomar, CA. Abstract #280, p. 106.

Development and Evaluation of an Affymetrix array for Aspergillus flavus - (Abstract)

Dolezal, A., Georgianna, D.R., Obrian, G., Woloshuk, C., Keller, N., Yu, J., Nielsen, D., Payne, G. 2007. Development and Evaluation of an Affymetrix array for Aspergillus flavus. In: Proceedings of the 24th Fungal Genetics Conference and the 4th International Aspergillus Meeting, March 18-25, 2007, Asilomar, CA. Abstract #143, p. 74.

Mycotoxin Production and Prevention of Aflatoxin Contamination in Food and Feed - (Book/Chapter)

Yu, J., Payne, G.A., Campbell, B.C., Guo, B., Cleveland, T.E., Robens, J.F., Keller, N.P., Bennett, J.W., Nierman, W.C. 2007. Mycotoxin Production and Prevention of Aflatoxin Contamination in Food and Feed, pp. 457-472. In: Osmani, S. and Goldman, G. (eds). The Aspergilli: Genomics, Medical Aspects, Biotechnology, and Research Methods, CRC Press, Boca Raton, FL.

Comparative and Functional Genomics in Identifying Aflatoxin Biosynthetic Genes - (Abstract)

Yu, J., Wilkinson, J., Payne, G., Machida, M., Campbell, B.C., Bennett, J., Bhatnagar, D., Cleveland, T.E., Nierman, W. 2007. Comparative and Functional Genomics in Identifying Aflatoxin Biosynthetic Genes. In: Proceedings of the 24th Fungal Genetics Conference and the 4th International Aspergillus Meeting, March 18-25, 2007, Asilomar, CA. p. 82.

Aspergillus flavus Genomic Data Mining Provides Clues for Its Use in Producing Biobased Products - (Abstract)

Yu, J., Nierman, W.C., Bhatnagar, D., Cleveland, T.E. 2007. Aspergillus flavus Genomic Data Mining Provides Clues for Its Use in Producing Biobased Products. In: Proceedings of the American Chemical Society National Meeting, March 25-29, 2007, Chicago, IL. p. 108.

A First Glance into the Genome Sequence of Aspergillus flavus - (Book/Chapter)

Payne, G.A., Yu, J., Nierman, W.C., Machida, M., Bhatnagar, D., Cleveland, T.E., Dean, R.A. 2007. A first glance into the genome sequence of aspergillus flavus, pp. 15-23. In: Osmani, S. and Goldman, G. (eds). The Aspergilli: Genomics, Medical Aspects, Biotechnology, and Research Methods, CRC Press, Boca Raton, FL.

The Use of Crop Proteomics and Fungal Genomics in Elucidating Fungus-Crop Interactions - (Abstract)

Cleveland, T.E., Yu, J., Chen, Z., Brown, R.L., Cary, J.W., Rajasekaran, K., Bhatnagar, D., Campbell, B.C., Nierman, W.C., Payne, G.A. 2006. The Use of Crop Proteomics and Fungal Genomics in Elucidating Fungus-Crop Interactions. In: Proceedings of the Myco-Globe Conference, September 26-30, 2006, Bari, Italy. p. 32.

The Effect of Elevated Temperature on Gene Transcription and Aflatoxin Biosynthesis - (Peer Reviewed Journal)

OBrian, G.R., Georgianna, D.R., Wilkinson, J.R., Yu, J., Abbas, H.K., Bhatnagar, D., Cleveland, T.E., Nierman, W.C., Payne, G.A. 2007. The Effect of Elevated Temperature on Gene Transcription and Aflatoxin Biosynthesis. Mycologia. 99(2):232-239.

AMINO ACID SUPPLEMENTATION REVEALS DIFFERENTIAL REGULATION OF AFLATOXIN BIOSYNTHESIS IN ASPERGILLUS FLAVUS NRRL 3357 AND ASPERGILLUS PARASITICUS SRRC 143 - (Peer Reviewed Journal)

Wilkinson, J.R., Yu, J., Bland, J.M., Nierman, W.C., Bhatnagar, D., Cleveland, T.E. 2007. Amino acid supplementation reveals differential regulation of aflatoxin biosynthesis in Aspergillus flavus NRRL 3357 and Aspergillus parasiticus SRRC 143. Applied Microbiology and Biotechnology. 74:1308-1319.

Genomics of Mycotoxigenic Fungi - (Book/Chapter)

Bhatnagar, D., Proctor, R., Payne, G.A., Wilkinson, J.R., Yu, J., Cleveland, T.E., Nierman, W.C. 2006. Genomics of Mycotoxigenic Fungi. In: Barug, D., Bhatnagar, D., van Egmond, H.P., van der Kamp, J.W., van Osenbruggen, W.A. Visconti, A., editors. The Mycotoxin Factbook. The Netherlands: Wageningen Academic Publishers. 400 p.

Understanding the Genetics of Regulation of Aflatoxin Production and Aspergillus flavus Development - (Review Article)

Bhatnagar, D., Cary, J.W., Ehrlich, K., Yu, J., Cleveland, T.E. 2006. Understanding the Genetics of Regulation of Aflatoxin Production and Aspergillus flavus Development. Mycopathologia. 162:155-166.

EST Profiling for Elucidation of Molecular Regulation of Aflatoxin bBiosynthesis in Aspergillus flavus - (Abstract)

Yu, J., Wilkinson, J.R., Cleveland, T.E., Campbell, B.C., Bhatnagar, D., Payne, G.A., Nierman, W.C. 2006. EST profiling for elucidation of molecular regulation of aflatoxin biosynthesis in Aspergillus flavus. In: Proceedings of the Myco-Globe Conference: Advances on Genomics, Biodiversity and Rapid Systems for Detection of Toxigenic Fungi and Mycotoxins, September 26-30, 2006, Bari, Italy. p. 29.

Aspergillus flavus Genomics for Discovering Genes Involved in Aflatoxin Biosynthesis - (Book/Chapter)

Yu, J., Cleveland, T.E. 2007. Aspergillus flavus Genomics for Discovering Genes Involved in Aflatoxin Biosynthesis. In: Rimando, A.M., Baerson, S.R., editors. American Chemical Society Symposium Series: Polyketides - Biosynthesis, Biological Activity, and Genetic Engineering. Washington, DC: American Chemical Society. 955:246-260.

MEDIA SHIFT OF ASPERGILLUS PARASITICUS CULTURES FOR STUDYING THE MOLECULAR REGULATION OF AFLATOXIN - (Abstract)

Wilkinson, J.R., Yu, J., Abbas, H.K., Scheffler, B.E., Kim, H.S., Nierman, W.C., Bhatnagar, D., Cleveland, T.E. 2006. Media shift of Aspergillus parasiticus cultures for studying the molecular regulation of aflatoxin. In: Proceedings of the American Society for Microbiology Annual Meeting, May 21-26, 2006, Orlando, FL. Abstract #O-064, p. 433.

INFLUENCE OF TRYPTOPHAN ON AFLATOXIN BIOSYNTHESIS AND REGULATION IN ASPERGILLUS FLAVUS - (Abstract)

Wilkinson, J.R., Yu, J., Bland, J.M., Scheffler, B.E., Kim, H.S., Nierman, W.C., Cleveland, T.E. 2006. Influence of tryptophan on aflatoxin biosynthesis and regulation in Aspergillus flavus. In: Proceedings of the American Society for Microbiology Annual Meeting, May 21-26, 2006, Orlando, FL. Abstract #O-042, p. 429.

TEMPERATURE DEPENDENT MOLECULAR REGULATION OF AFLATOXIN BIOSYNTHESIS - (Abstract)

Obrian, G.R., Georgiana, D.R., Wilkinson, J.R., Yu, J., Bhatnagar, D., Cleveland, T.E., Payne, G.A. 2006. Temperature dependent molecular regulation of aflatoxin biosynthesis. In: Proceedings of the American Society for Microbiology Annual Meeting, May 21-26, 2006, Orlando, FL. Abstract #O-063, p. 433.

WHOLE GENOME COMPARISON OF ASPERGILLUS FLAVUS AND A. ORYZAE - (Review Article)

Payne, G.A., Nierman, W.C., Wortman, J.R., Pritchard, B.L., Brown, D., Dean, R.A., Bhatnagar, D., Cleveland, T.E., Machida, M., Yu, J. 2006. Whole genome comparison of Aspergillus flavus and A. oryzae. Medical Mycology. 44:9-11.

THE SEC- MUTANT OF ASPERGILLUS PARASITICUS IS ALTERED IN ITS PROFILE OF SECONDARY METABOLITES - (Abstract)

Glassbrook, N.J., Kale, S.P., Bhatnagar, D., Wilkinson, J.R., Yu, J., Cary, J.W., Cleveland, T.E., Payne, G.A. 2006. The sec- mutant of Aspergillus parasiticus is altered in its profile of secondary metabolites. In: Proceedings of the American Society for Microbiology Annual Meeting, May 21-26, 2006, Orlando, FL. Abstract #O-040, p. 428.

TRYPTOPHAN¿S EFFECTS ON AFLATOXIN BIOSYNTHESIS AND ITS REGULATION IN ASPERGILLUS FLAVUS - (Abstract)

Wilkinson, J.R., Yu, J., Bland, J.M., Scheffler, B.E., Kim, H.S., Nierman, W.C., Cleveland, T.E. 2006. Tryptophan¿s effects on aflatoxin biosynthesis and its regulation in Aspergillus flavus. In: Proceedings of the 8th European Conference on Fungal Genetics, April 6-12, 2006, Vienna, Austria. p. 68.

AFLATOXINS: BACKGROUND, TOXICOLOGY, AND MOLECULAR BIOLOGY - (Book/Chapter)

Bennett, J.W., Kale, S., Yu, J. 2008. Aflatoxins: Background, Toxicology, and Molecular Biology.In: Simjee, S., editor. Infectious Disease: Foodborne Diseases. Totowa, NJ: Humana Press. 13:355-373.

ASPERGILLUS FLAVUS EXPRESSED SEQUENCE TAGS AND MICROARRAY AS TOOLS IN UNDERSTANDING AFLATOXIN BIOSYNTHESIS - (Peer Reviewed Journal)

Yu, J., Cleveland, T.E., Wilkinson, J.R., Campbell, B.C., Kim, J.H., Kim, H.S., Bhatnagar, D., Payne, G.A., Nierman, W.C. 2006. Aspergillus flavus expressed sequence tags and microarray as tools in understanding aflatoxin biosynthesis. Mycotoxin Research. 22(1):16-21.

GENE TARGETS FOR FUNGAL AND MYCOTOXIN CONTROL - (Peer Reviewed Journal)

Campbell, B.C., Kim, J.H., Molyneux, R.J., Mahoney, N.E., Chan, K.L, Yu, J., Wilkinson, J.R., Cary, J.W., Bhatnagar, D., Cleveland, T.E. 2006. Gene targets for fungal and mycotoxin control. Mycotoxin Research. 22(1):3-8.

The Aflatoxin Pathway Regulator AFLR Induces Gene Transcription Inside and Outside of the Aflatoxin Biosynthetic Cluster - (Peer Reviewed Journal)

Price, M.S., Yu, J., Nierman, W.C., Kim, H.S., Pritchard, B., Jacobus, C.A., Bhatnagar, D., Cleveland, T.E., Payne, G.A. 2006. The aflatoxin pathway regulator AflR induces gene transcription inside and outside of the aflatoxin biosynthetic cluster. Federation of European Microbiological Societies Microbiology Letters. 255:275-279.

Aspergillus flavus Genomics: Gateway to Human and Animal Health, Food Safety, and Crop Resistance to Diseases - (Peer Reviewed Journal)

Yu, J., Cleveland, T.E., Nierman, W.C., Bennett, J. 2005. Aspergillus flavus Genomics: Gateway to Human and Animal Health, Food Safety, and Crop Resistance to Diseases. Revista Iberoamericana De Micologia. 22:194-202.

GENOMICS OF ASPERGILLUS FUMIGATUS - (Peer Reviewed Journal)

Ronning, C.M., Fedorova, N.D., Bowyer, P., Coulson, R., Goldman, G., Kim, H.S., Turner, G., Wortman, J.R., Yu, J., Anderson, M.J., Denning, D.W., Nierman, W.C. 2005. Genomics of Aspergillus fumigatus. Revista Iberoamericana De Micologia. 22:223-228.

APPLICATION OF TECHNOLOGY OF GENE EXPRESSION IN RESPONSE TO DROUGHT STRESS AND ELIMINATION OF PREHARVEST AFLATOXIN CONTAMINATION - (Peer Reviewed Journal)

Guo, B., Holbrook, Jr., C. C., Yu, J., Lee, R. D., Lynch, R. E. 2005. Application of technology of gene expression in response to drought stress and elimination of preharvest aflatoxin contamination. In: Abbas, H. (ed.). Aflatoxin and Food Safety. Boca Raton, Florida: CRC Press. Pp. 313-331.

Aflatoxins in Stored Maize and Rice Grains in Liaoning Province, China - (Peer Reviewed Journal)

Liu, Z., Gao, J., Yu, J. 2006. Aflatoxins in Stored Maize and Rice Grains in Liaoning Province, China. Journal of Stored Products Research. 42:468-479.

GENOME SEQUENCING AND ANALYSIS OF ASPERGILLUS ORYZAE - (Peer Reviewed Journal)

Machida, M., Asai, K., Sano, M., Tanaka, T., Kumagai, T., Terai, G., Kusumoto, K., Arima, T., Akita, O., Kashiwagi, Y., Abe, K., Gomi, K., Horiuchi, H., Kitamoto, K., Kobayashi, T., Takeuchi, M., Denning, D.W., Galagan, J.E., Nierman, W.C., Yu, J., Archer, D., Bhatnagar, D., Cleveland, T.E., Gotoh, O., Horikawa, H., Hosoyama, A., Ichinomiya, M., Igarashi, R., Iwashita, K., Juvvadi, P., Kato, M., Kato, Y., Kin, T., Kokubun, A., Maeda, H., Maeyama, N., Maruyama, J., Nagasaki, H., Nakajima, T., Oda, K., Okada, K., Paulsen, I., Sakamoto, K., Sawano, T., Takahashi, M., Takase, K., Terabayashi, T., Wortman, J., Yamada, O., Yamagata, O., Anazawa, H., Hata, Y., Koide, Y., Komori, T., Koyama, Y., Minetoki, T., Suharnan, S., Tanaka, A., Isono, K., Kuhara, S., Ogasawara, N., Kikuchi, H. 2005. Genome sequencing and analysis of Aspergillus oryzae. Nature. 438(7071):1157-1161.

Batch Submission and Release of 19,618 Aspergillus flavus Expressed Sequence Tags (ESTs) - (Other)

Yu, J., Nierman, W.C., Bhatnagar, D., Cleveland, T.E. 2006. Batch Submission and Release of 19,618 Aspergillus flavus Expressed Sequence Tags (EST). National Center for Biotechnology Information (NCBI). (NCBI, http://www.ncbi.nlm.nih.gov/), CO133039-CO152656.

Classification, Analysis, and Release of Aspergillus flavus Gene Index Consisting of 7,218 Expressed Unique Genes - (Other)

Yu, J., Cleveland, T.E., Bhatnagar, D., Nierman, W.C. 2006. Classification, Analysis, and Release of Aspergillus flavus Gene Index Consisting of 7,218 Expressed Unique Genes. In: The Institute for Genomic Research and The Dana Farber Cancer Institute ().

ASPERGILLUS FLAVUS GENOMICS FOR STUDYING THE MECHANISM OF AFLATOXIN BIOSYNTHESIS - (Abstract)

Yu, J., Wilkinson, J.R., Kim, H.S., Nierman, W.C., Kim, J.H., Campbell, B.C., Bhatnagar, D., Cleveland, T.E. 2005. Aspergillus flavus genomics for studying the mechanism of aflatoxin biosynthesis. International Union of Microbiological Societies (IUMS) Proceedings/Abstracts, July 23-28, 2005, San Francisco, CA. p. 6.

The Aflatoxin Pathway Regulatory Gene aflR Regulates Genes Outside of the Aflatoxin Biosynthetic Cluster - (Other)

Price, M.S., Yu, J., Bhatnagar, D., Cleveland, T.E., Nierman, W.C., Pritchard, B., Payne, G.A. 2005. The Aflatoxin Pathway Regulatory Gene aflR Regulates Genes Outside of the Aflatoxin Biosynthetic Cluster [Ph D Dissertation]. Raleigh, NC: North Carolina State University. 80 p.

PROFILING OF GENES PUTATIVELY INVOLVED ON AFLATOXIN BIOSYNTHESIS USING ASPERGILLUS FLAVUS MICROARRAYS - (Abstract)

Yu, J., Wilkinson, J.R., Kim, H., Nierman, W.C., Payne, G.A., Bennett, J.W., Kim, J.H., Campbell, B.C., Bhatnagar, D., Cleveland, T.E. 2005. Profiling of genes putatively involved on aflatoxin biosynthesis using Aspergillus flavus microarrays. American Society for Microbiology Meeting, June 6-9, 2005, Atlanta, GA. p. 426.

ASPERGILLUS FLAVUS GENOME SEQUENCE: INITIAL ANALYSIS - (Abstract)

Payne, G.A., Pritchard, B.L., Yu, J., Nierman, W.C., Dean, R.A., Bhatnagar, D., Cleveland, T.E. 2005. Aspergillus flavus genome sequence: Initial analysis. 23rd Fungal Genetic Conference and 2nd Aspergillus Meeting, Asilomar Conference Center, March 13-20, 2005, Pacific Grove, CA. p. 96.

FUNCTIONAL GENOMICS STUDIES FOR IDENTIFYING GENES INVOLVED IN AFLATOXIN FORMATION IN ASPERGILLUS FLAVUS - (Abstract)

Yu, J., Wilkinson, J.R., Kim, H., Nierman, W.C., Payne, G.A., Bennett, J.W., Kim, J.H., Campbell, B.C., Bhatnagar, D., Cleveland, T.E. 2005. Functional genomics studies for identifying genes involved in aflatoxin formation in Aspergillus flavus. 23rd Fungal Genetic Conference and 2nd Aspergillus Meeting, Asilomar Conference Center, March 13-20, 2005, Pacific Grove, CA. p. 203.

AFLATOXIN BIOSYNTHESIS GENE CLUSTERS AND FLANKING REGIONS - (Peer Reviewed Journal)

Ehrlich, K.C., Yu, J., Cotty, P.J. 2005. Aflatoxin biosynthesis gene clusters and flanking regions. Journal of Applied Microbiology. 99:518-527.

EXAMINATION OF FUNGAL STRESS RESPONSE GENES USING SACCHAROMYCES CEREVISIAE AS A MODEL SYSTEM: TARGETING GENES AFFECTING AFLATOXIN BIOSYNTHESIS BY ASPERGILLUS FLAVUS LINK. - (Peer Reviewed Journal)

Kim, J.H., Campbell, B.C., Molyneux, R.J., Mahoney, N.E., Chan, K.L., Yu, J., Wilkinson, J.R., Cary, J.W., Bhatnagar, D., Cleveland, T.E. 2005. Examination of fungal stress response genes using saccharomyces cerevisiae as a model system: targeting genes affecting aflatoxin biosynthesis by Aspergillus Flavus Link. Applied Microbiology and Biotechnology. 67(6):807-815.

SECONDARY METABOLITE BIOSYNTHETIC GENE CLUSTERS IN FILAMENTOUS FUNGI - (Abstract)

Nierman, W.C., Fedorova, N., Ronning, C.M., Kulkarni, R., Denning, D., Anderson, M., Machida, M., Kitamoto, K., Asai, K., Bennett, J., Payne, G.A., Yu, J., Bhatnagar, D., Cleveland, T.E., Wortman, J., Ravel, J. 2005. Secondary metabolite biosynthetic gene clusters in filamentous fungi. 23rd Fungal Genetic Conference and 2nd Aspergillus Meeting, Asilomar Conference Center, March 13-20, 2005, Pacific Grove, CA. p. 95.

AFLT, A MFS TRANSPORTER-ENCODING GENE LOCATED IN THE AFLATOXIN GENE CLUSTER, DOES NOT HAVE A SIGNIFICANT ROLE IN AFLATOXIN SECRETION - (Peer Reviewed Journal)

Chang, P.-K., Yu, J., Yu, J.-H. 2004. aflT, a MFS transporter-encoding gene located in the aflatoxin gene cluster, does not have a significant role in aflatoxin secretion. Fungal Genetics and Biology. 41:911-920.

PROFILING OF GENES RELATED TO AFLATOXIN FORMATION USING ASPERGILLUS FLAVUS MICROARRAY - (Abstract)

Yu, J., Bhatnagar, D., Cleveland, T.E. 2004. Profiling of genes related to aflatoxin formation using Aspergillus flavus microarray. Great Lakes Regional American Chemical Society Symposium, October 17-20, Peoria, IL. p. 60.

ASPERGILLUS FLAVUS EXPRESSED SEQUENCE TAGS FOR IDENTIFICATION OF GENES WITH PUTATIVE ROLES IN AFLATOXIN CONTAMINATION OF CROPS - (Peer Reviewed Journal)

Yu, J., Whitelaw, C.A., Nierman, W.C., Bhatnagar, D., Cleveland, T.E. 2004. Aspergillus flavus expressed sequence tags for identification of genes with putative roles in aflatoxin contamination of crops. Federation of European Microbiological Societies Microbiol Letters. 237:333-340.

THE AFLATOXIN BIOSYNTHESIS CLUSTER GENE CYPA IS REQUIRED FOR AFLATOXIN G1 AND G2 FORMATION - (Peer Reviewed Journal)

Ehrlich, K.C., Chang, P.-K., Yu, J., Cotty, P.J. 2004. Aflatoxin biosynthesis cluster gene cypA is required for G aflatoxin formation. Applied and Environmental Microbiology. 70(11):6518-6524.

ASPERGILLUS FLAVUS GENOMICS FOR SOLVING AFLATOXIN CONTAMINATION IN CROPS - (Abstract)

Yu, J., Nierman, W.C., Payne, G.A., Bhatnagar, D., Cleveland, T.E. 2004. Aspergillus flavus genomics for solving aflatoxin contamination in crops. Annual Conference of the U.S.-Japan Cooperative Program in Natural Resources (UJNR), October 7-13, 2004, Atlanta, GA. p. 14.

GENOMICS OF ASPERGILLUS SPP FOR CONTROLLING HARMFUL TOXINS AND HARNESSING BENEFICIAL METABOLITES - (Abstract)

Bhatnagar, D., Yu, J., Cleveland, T.E. Genomics of Sspergillus species for controlling harmful toxins and harnessing beneficial metabolites [abstract]. Society of Industrial Microbiology Annual Meeting, July 25-29, 2004, Anaheim, California.

PROFILING OF GENES INVOLVED IN AFLATOXIN PRODUCTION IN ASPERGILLUS FLAVUS BY EXPRESSED SEQUENCE TAGS AND MICROARRAY - (Abstract)

Yu, J., Kim, H., Wilkinson, J.R., Nierman, W.C., Bhatnagar, D., Cleveland, T.E. 2004. Profiling of genes involved in aflatoxin production in Aspergillus flavus by expressed sequence tags and microarray [abstract]. Society of Industrial Microbiology Annual Meeting, July 25-29, 2004, Anaheim, California.

ASPERGILLUS GENOMICS: UNDERSTANDING FUNGAL ECOLOGY AND AFLATOXIN PRODUCTION - (Abstract)

Bhatnagar, D., Yu, J., Ehrlich, K., Cleveland, T.E. Aspergillus genomics: Understanding fungal ecology and aflatoxin production [abstract]. International Union of Pure and Applied Chemistry (IUPAC) Symposium on Mycotoxins and Phycotoxins, May 17-21, 2004, Bethesda, Maryland.

TARGETING STRESS-RESPONSE GENES FOR CONTROL OF MYCOTOXIN BIOSYNTHESIS IN ASPERGILLUS - (Abstract)

Kim, J.H., Yu, J., Bhatnagar, D., Cleveland, T.E., Campbell, B.C. 2004. Targeting stress-response genes for control of mycotoxin biosynthesis in Aspergillus [abstract]. 7th European Conference on Fungal Genetics and 1st Aspergillus Workshop, April 17-21, 2004, Copenhagen, Denmark.

COMPLETED SEQUENCE OF AFLATOXIN PATHWAY GENE CLUSTER IN ASPERGILLUS PARASITICUS - (Peer Reviewed Journal)

Yu, J., Bhatnagar, D., Cleveland, T.E. 2004. Completed sequence of aflatoxin pathway gene cluster in aspergillus parasiticus. Federation of European Biochemical Societies Letters. 564:126-130.

GENETIC AND BIOCHEMICAL STUDIES ON THE MECHANISMS OF AFLATOXIN BIOSYNTHESIS - (Abstract)

Yu, J., Cleveland, T.E., Bhatnagar, D. 2004. Genetic and biochemical studies on the mechanisms of aflatoxin biosynthesis [abstract]. 7th European Conference on Fungal Genetics and 1st Aspergillus Workshop, April 17-21, 2004, Copenhagen, Denmark.

Progress in Elucidating the Molecular Basis of the Host Plant-Aspergillus flavus Interaction: A Basis for Devising Strategies to Reduce Aflatoxin Contamination in Crops - (Book/Chapter)

Cleveland, T.E., Yu, J., Bhatnagar, D., Chen, Z.-Y., Brown, R.L., Chang, P., Cary, J.W. 2005. Progress in Elucidating the Molecular Basis of the Host Plant-Aspergillus flavus Interaction: A Basis for Devising Strategies to Reduce Aflatoxin Contamination in Crops. In: Abbas, H.K., editor. Aflatoxin and Food Safety. Boca Raton, FL: Taylor & Francis. p. 167-193.

GENE PROFILING BY EST AND MICROARRAY IN ASPERGILLUS FLAVUS FOR CONTROLLING AFLATOXIN CONTAMINATION IN CROPS - (Abstract)

Yu, J., Kim, H., Whitelaw, C.A., Nierman, W.C., Bhatnagar, D., Cleveland, T.E. 2004. Gene profiling by EST and microarray in Aspergillus flavus for controlling aflatoxin contamination in crops [abstract]. 7th European Conference on Fungal Genetics and 1st Aspergillus Workshop, April 17-21, 2004, Copenhagen, Denmark.

AFLATOXIN BIOSYNTHETIC GENE PROFILING IN ASPERGILLUS FLAVUS BY EST AND MICROARRAY - (Abstract)

Yu, J., Kim, H., Cleveland, T.E., Bhatnagar, D., Nierman, W.C. 2004. Aflatoxin biosynthetic gene profiling in Aspergillus flavus by EST and microarray [abstract]. American Society for Microbiology Annual Meeting, New Orleans, Louisiana.

CONVERSION OF VERSICONAL HEMIACETAL ACETATE TO VERSICONAL AND VERSICONOL ACETATE TO VERSICONOL BY ASPERGILLUS PARASITICUS ESTA-ENCODED ESTERASE DURING AFLATOXIN BIOSYNTHESIS - (Abstract)

Chang, P.-K., Yabe, K., Yu, J. 2004. Conversion of versiconal hemiacetal acetate to versiconal and versiconol acetate to versiconol by Aspergillus parasiticus estA-encoded esterase during aflatoxin biosynthesis [abstract]. Annual Meeting of American Society for Microbiology, New Orleans, Louisiana.

ASPERGILLUS GENOME PROJECT - (Abstract)

Bhatnagar, D., Yu, J., Cleveland, T.E. Aspergillus genome project [abstract]. International Symposium on Mycotoxins and Phytotoxins, May 17-21, 2004, Bethesda, Maryland.

GENETICS AND BIOCHEMISTRY OF AFLATOXIN FORMATION AND GENOMICS APPROACH FOR ELIMINATING AFLATOXIN CONTAMINATION - (Review Article)

Yu, J., Bhatnagar, D., Cleveland, T.E. 2004. Genetics and biochemistry of aflatoxin formation and genomics approach for eliminating aflatoxin contamination. In: Romeo, J.T., editor. Recent Advances in Phytochemistry: Secondary Metabolism in Model Systems. Elsevier. 38:224-242.

THE CLUSTERED PATHWAY GENES IN AFLATOXIN BIOSYNTHESIS - (Review Article)

Yu, J., Chang, P.-K., Ehrlich, K., Cary, J.W., Bhatnagar, D., Cleveland, T.E., Payne, G.A., Linz, J.E., Woloshuk, C.P., Bennett, J.W. 2004. The clustered pathway genes in aflatoxin biosynthesis. Applied And Environmental Microbiology. 70(3):1253-1262.

CHARACTERIZATION OF THE COMPLETE AFLATOXIN PATHWAY GENE CLUSTER IN ASPERGILLUS PARASITICUS - (Abstract)

Yu, J., Chang, P.-K., Ehrlich, K., Cary, J.W., Bhatnagar, D., Cleveland, T.E. 2003. Characterization of the complete aflatoxin pathway gene cluster in Aspergillus parasiticus. Proceedings of USDA-ARS Aflatoxin/Fumonisin Elimination and Fungal Genomics Workshop, October 13-15, 2003, Savannah, Georgia.

ASPERGILLUS FLAVUS EST AND MICROARRAY IN IDENTIFYING TARGET GENES FOR CONTROLLING AFLATOXIN CONTAMINATION - (Abstract)

Yu, J., Whitelaw, C.A., Cleveland, T.E., Bhatnagar, D., Nierman, W.C. 2003. Aspergillus flavus EST and microarray in identifying target genes for controlling aflatoxin contamination [abstract]. Multicrop Aflatoxin and Fumonisin Elimination and Fungal Genomics Workshop, The Peanut Foundation, October 13-15, 2003, Savannah, Georgia.

Elucidation of the Molecular Basis of the Host Plant-Aspergillus flavus Interaction, a Basis for Devising Strategies to Reduce Aflatoxin Contamination in Crops - (Review Article)

Cleveland, T.E., Yu, J., Bhatnagar, D., Chen, Z.-Y., Brown, R.L., Chang, P.-K., Cary, J.W. 2004. Elucidation of the molecular basis of the host plant-Aspergillus flavus interaction, a basis for devising strategies to reduce aflatoxin contamination in crops. In: Shier, W.T., Tu, A.T., Yu, C., Abbas, H.K., editors. Journal of Toxicology - Toxin Reviews. New York, NY: Marcel Dekker, Inc. 23(2,3):345-380.

THE ASPERGILLUS PARASITICUS ESTA-ENCODED ESTERASE CONVERTS VERSICONAL HEMIACETAL ACETATE TO VERSICONAL AND VERSICONOL ACETATE TO VERSICONOL IN AFLATOXIN BIOSYNTHESIS - (Peer Reviewed Journal)

Chang, P.-K., Yabe, K., Yu, J. 2004. The Aspergillus parasiticus estA-encoded esterase converts versiconal hemiacetal acetate to versiconal and versiconol acetate to versiconol. Applied and Environmental Microbiology. 70:3593-3599.

Substrate-induced Lipase Gene Expression and Aflatoxin Production in Aspergillus parasiticus and Aspergillus flavus - (Peer Reviewed Journal)

Yu, J., Mohawed, S.M., Bhatnagar, D., Cleveland, T.E. 2003. Substrate-induced Lipase Gene Expression and Aflatoxin Production in Aspergillus parasiticus and Aspergillus flavus. Journal of Applied Microbiology. 95(6):1334-1342.

GENOMICS OF ECONOMICALLY SIGNIFICANT ASPERGILLUS AND FUSARIUM SPECIES - (Book/Chapter)

Yu, J., Proctor, R.H., Brown, D.W., Abe, K., Gomi, K., Machida, M., Hasegawa, F., Nierman, W.C., Bhatnagar, D., Cleveland, T.E. 2004. Genomics of economically significant aspergillus and fusarium species. In: Arora, D.K., Khachatourians, G.G.. Applied Mycology and Biotechnology: Fungal Genomics. v. 4. Elsevier Science B.V. p. 249-283.

Metal Ion Enhancement on Fungal Growth, Gene Expression and Aflatoxin Synthesis in Aspergillus flavus: RT-PCR Characterization - (Peer Reviewed Journal)

Cuero, R., Ouellet, T., Yu, J., Mogongwa, N. 2003. Metal Ion Enhancement on Fungal Growth, Gene Expression and Aflatoxin Synthesis in Aspergillus flavus: RT-PCR Characterization. Journal of Applied Microbiology. 94:953-961.

APPLICATION OF DIFFERENTIAL DISPLAY RT-PCR AND EST/MICROARRAY TECHNOLOGIES TO THE ANALYSIS OF GENE EXPRESSION IN RESPONSE TO DROUGHT STRESS AND ELIMINATION OF ALFATOXIN CONTAMINATION IN CORN AND PEANUT - (Peer Reviewed Journal)

Guo, B.Z., Yu, J., Holbrook, C.C., Lee, R.D., Lynch, R.E. 2003. Application of differential display RT-PCR and EST-microarray technologies to the analysis of gene expression in response to drought stress and elimination of aflatoxin contamination in corn and peanut. Journal of Toxicology Toxin Reviews. 22(2&3):287-312.

AFLATOXIN BIOSYNTHESIS - (Review Article)

Yu, J., Bhatnagar, D., Ehrlich, K. 2002. Aflatoxin biosynthesis. Revista Iberoamericana De Micologia. 19:191-200.

GENETICS AND BIOCHEMISTRY OF MYCOTOXIN SYNTHESIS - (Book/Chapter)

Yu, J. 2004. Genetics and biochemistry of mycotoxin synthesis. In: Arora, D.K., editor. Fungal Biotechnology in Agricultural, Food, and Environmental Applications. New York, NY: Marcel Dekker, Inc. p. 343-361.