When tobacco is smoked, nicotine is absorbed by the lungs and quickly moved into the bloodstream, where it is circulated throughout the brain. PDF for Mind Over Matter - Tobacco Addiction [PDF - 688 KB] The Brain's Response to Nicotine How Does Nicotine Act in the Brain? Easy to Start, Hard to Quit America's Leading Preventable Killer Got A Match? The Search Continues The Brain's Response to Nicotine › Español