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"health-related quality of life"

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Outcomes and Applicability: Examples. Trials of biologics for rheumatoid arthritis that used radiographic progression rather than symptom evaluations as an outcome measure. Trials comparing cyclooxygenase-2 inhibitors and nonsteroidal antiinflammatory drugs that used endoscopy-evaluated ulceration rather than symptomatic ulcers as an outcome measure.
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Outcomes and Applicability: Examples

Presentation: Assessing Applicability
Keywords: outcomes | applicability
This slide graphically presents numerical differences in the incidence of late xerostomia reported by nine different reports comparing IMRT vs. 2DRT. The difference in percentages of adverse avents that occurred with IMRT vs. 2DRT ranged from 43% to 62%. Consistent between-group differences were found for two outcomes: late xerostomia and health-related quality of life domains related to xerostomia.Eight were statistically significant in favor of IMRT.
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Studies Regarding Late Xerostomia: IMRT vs. 2DRT

Presentation: Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Keywords: 2DRT | adverse events | head and neck cancer | IMRT | outcomes | quality of life | radiotherapy | xerostomia | comparative effectiveness
Clinical Outcomes of Interest Outcomes of interest include health-related quality of life, shoulder function, time to return to work, cuff integrity, pain, range of motion, and strength of the shoulder.
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Clinical Outcomes of Interest

Presentation: Comparative Effectiveness of Nonoperative and Operative Treatments for Rotator Cuff Tears
Keywords: outcomes | health-related quality of life | shoulder function | time to return to work | cuff integrity | pain | range of motion | shoulder strength
Four Domains Used To Assess Relevant Studies The following four major domains were examined: risk of bias (low, medium, high), consistency (no inconsistency, inconsistency present, unknown, or not applicable), directness (direct, indirect), and precision (precise, imprecise). Four of the outcomes (health-related quality of life, shoulder function, cuff integrity and time to return to work) for each comparison of interest were given an overall evidence grade based on the ratings for the individual domains.
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Four Domains Used To Assess Relevant Studies

Presentation: Comparative Effectiveness of Nonoperative and Operative Treatments for Rotator Cuff Tears
Keywords: comparative effectiveness | nonoperative | operative | rotator cuff tear
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Evaluating JIA Assessment Instruments (1 of 3)

Presentation: Disease-Modifying Antirheumatic Drugs in Children With Juvenile Idiopathic Arthritis
Keywords: active joint count | anti-rheumatic | antirheumatic | assessment | biologic DMARD | CHAQ | CHQ | disease-modifying | DMARDs | JCA | JIA | JRA | juvenile rheumatoid arthritis | non-biologic DMARD | nonbiologic DMARD | parent global assessment of well-being | PedsQL | PedsQL-RM | physician global assessment | reliability | responsiveness | rheumatic | TNF-alpha blockers | validity | juvenile idiopathic arthritis
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Analytic Methods Used in the Systematic Review

Presentation: Drug Therapy for Rheumatoid Arthritis in Adults
Keywords: rheumatoid arthritis | RA | DMARDs | disease-modifying | antirheumatic | anti-rheumatic | rheumatic | biologic | oral | ACR20 | disease activity | functional ability | HAQ | Health Assessment Questionnaire | health-related quality of life | SF-36 | Sharp/van de Heijde | joint damage
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Clinical Questions Addressed by the CER (1)

Presentation: Effectiveness of Recombinant Human Growth Hormone (rhGH) in the Treatment of Patients with Cystic Fibrosis
Keywords: intermediate outcomes | health outcomes | pulmonary function | body composition | bone mineralization | pulmonary exacerbation | mortality risk | health related quality of life | HRQoL | QoL | quality of life | cystic fibrosis | CF | rhGH | recombinant human growth hormone | human growth hormone | HGH
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Outcomes of Interest in Studies of rhGH Treatment of Patients With CF

Presentation: Effectiveness of Recombinant Human Growth Hormone (rhGH) in the Treatment of Patients with Cystic Fibrosis
Keywords: intermediate outcomes | health outcomes | outcomes | pulmonary function | anthropometrics | bone mineralization | exercise tolerance | hospitalization rate | intravenous antibiotics | antibiotic use | health related quality of life | HRQoL | QoL | quality of life | bone consequences | mortality | cystic fibrosis | CF | rhGH | recombinant human growth hormone | human growth hormone | HGH
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Intermediate End Points and Health Outcomes in rhGH-Treated Patients With CF (1)

Presentation: Effectiveness of Recombinant Human Growth Hormone (rhGH) in the Treatment of Patients with Cystic Fibrosis
Keywords: intermediate | outcome | end point | health outcome | mortality | health related quality of life | HRQoL | QoL | quality of life | cystic fibrosis | CF | rhGH | recombinant human growth hormone | human growth hormone | HGH
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Intermediate End Points and Health Outcomes in rhGH-Treated Patients With CF (2)

Presentation: Effectiveness of Recombinant Human Growth Hormone (rhGH) in the Treatment of Patients with Cystic Fibrosis
Keywords: mortality | health related quality of life | HRQoL | QoL | quality of life | cystic fibrosis | CF | rhGH | recombinant human growth hormone | human growth hormone | HGH
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Intermediate End Points and Health Outcomes in rhGH-Treated Patients With CF (3)

Presentation: Effectiveness of Recombinant Human Growth Hormone (rhGH) in the Treatment of Patients with Cystic Fibrosis
Keywords: regression | multivariate | univariate | anthropometrics | mortality | health related quality of life | HRQoL | QoL | quality of life | cystic fibrosis | CF | rhGH | recombinant human growth hormone | human growth hormone | HGH
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Intermediate End Points and Health Outcomes in rhGH-Treated Patients With CF (4)

Presentation: Effectiveness of Recombinant Human Growth Hormone (rhGH) in the Treatment of Patients with Cystic Fibrosis
Keywords: CF | HGH | HRQoL | QoL | anthropometrics | cystic fibrosis | health related quality of life | human growth hormone | mortality | multivariate | pulmonary function | quality of life | recombinant human growth hormone | regression | rhGH | univariate
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