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"knowledge gaps"

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Knowledge Gaps and Future Research Needs (1 of 3)

Presentation: Analgesics for Osteoarthritis—An Update
Keywords: knowledge gaps | future research | CV risks | GI benefits | COX-2 selective NSAIDs
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Knowledge Gaps and Future Research Needs (2 of 3)

Presentation: Analgesics for Osteoarthritis—An Update
Keywords: knowledge gaps | future research | COX-2 inhibitors | risks | CV safety | GI safety | nonselective NSAIDs | aspirin | salsalate | acetaminophen | alternative dosing
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Knowledge Gaps and Future Research Needs (3 of 3)

Presentation: Analgesics for Osteoarthritis—An Update
Keywords: knowledge gaps | future research | glucosamine | benefits | comparative risks | CV adverse effects | GI adverse effects | topical NSAIDs
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Gaps in Knowledge

Presentation: Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Testing for the Evaluation of Musculoskeletal Complaints in Pediatric Populations
Keywords: knowledge gaps | quality of life | psychosocial well-being | anxiety | undiagnosed musculoskeletal pain | serological tests | test performance | antinuclear antibody | cyclic-citrullinated peptide | rheumatoid factor | age | sex | race | ethnicity | recent infection
In the trials that this Comparative Effectiveness Review (CER) was based on, only a few had detailed subanalyses of disease or patient characteristics that correlated with the improved patient outcomes derived from adding an angiotensin-converting enzyme inhibitor (ACEI) or an angiotensin II receptor blocker (ARB) to the treatment regimen of patients with stable ischemic heart disease (IHD) and preserved left ventricular systolic function (LVSF). In addition, harms data were not available for many of the subpopulation analyses. Therefore, this evidence should be used mainly to generate hypotheses. From the subpopulation analyses, it is clear that more evidence is needed to determine whether there are patient characteristics or clinical factors that can determine whether patients with stable IHD and preserved LVSF will benefit more or less from the addition of an ACEI or an ARB to their standard therapies. Gender, diabetic status, the presence or absence of hypertension, the presence or absence of specific concomitant therapies, or a patient’s history of revascularization are all potential factors that may play a role in responsiveness to ACEIs or ARBs. Additional meta-analyses and clinical trials are needed to determine the benefits and harms of ACEIs and ARBs to these different subpopulations of patients.
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Gaps in Knowledge About ACEIs and ARBs as Treatment for Stable Ischemic Heart Disease With Preserved Left Ventricular Systolic Function

Presentation: Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors and/or Angiotensin II Receptor Blockers Added to Standard Medical Therapy for Treating Patients With Stable Ischemic Heart Disease and Preserved Left Ventricular Systolic Function
Keywords: angiotensin II-receptor blocker | angiotensin-converting enzyme inhibitor | comparative effectiveness | future research | stable ischemic heart disease | gaps in knowledge
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Knowledge Gaps and Future Research Needs

Presentation: Comparative Effectiveness of Management Strategies for Adults With Gastroesophageal Reflux Disease: An Update
Keywords: knowledge gaps | future research needs | insufficient evidence | GERD | behavioral modifications | extraesophageal | refractory symptoms
Gaps in Present Knowledge Additional comparative effectiveness research of open, mini-open, and arthroscopic approaches is a priority, as arthroscopic procedures are more costly and technically more difficult. Studies are needed on the effectiveness of early vs. delayed surgery and nonoperative vs. operative interventions. Also needed are appropriate comparisons of nonoperative treatments, the use of augmentation, analyses of the long-term effectiveness of treatments (minimum of 12 months), and the influence of patient prognostic factors.
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Gaps in Present Knowledge

Presentation: Comparative Effectiveness of Nonoperative and Operative Treatments for Rotator Cuff Tears
Keywords: nonoperative | operative | postoperative rehabilitation | rotator cuff tear | gaps in knowledge
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Knowledge Gaps and Future Research Needs

Presentation: Diagnosis and Treatment of Obstructive Sleep Apnea in Adults
Keywords: knowledge gaps | future research needs | insufficient evidence | apnea-hypopnea index | AHI | mandibular advancement device | MAD | continuous positive airway pressure | CPAP | treatment | surgery
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Knowledge Gaps and Future Research Needs

Presentation: Disease-Modifying Antirheumatic Drugs in Children With Juvenile Idiopathic Arthritis
Keywords: juvenile idiopathic arthritis | JIA | JRA | juvenile rheumatoid arthritis | JCA | DMARDs | disease-modifying | antirheumatic | anti-rheumatic | rheumatic | TNF-alpha blockers | biologic DMARD | nonbiologic DMARD | non-biologic DMARD
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Knowledge Gaps and Future Research Needs (1)

Presentation: Effectiveness of Recombinant Human Growth Hormone (rhGH) in the Treatment of Patients with Cystic Fibrosis
Keywords: effectiveness | harms | benefits | dosage | duration | pubertal | clinical | nutritional | cystic fibrosis | CF | rhGH | recombinant human growth hormone | human growth hormone | HGH
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Knowledge Gaps and Future Research Needs (2)

Presentation: Effectiveness of Recombinant Human Growth Hormone (rhGH) in the Treatment of Patients with Cystic Fibrosis
Keywords: cystic fibrosis | CF | rhGH | recombinant human growth hormone | human growth hormone | HGH
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Knowledge Gaps and Future Research Needs (1 of 3)

Presentation: Insulin Delivery and Glucose Monitoring Methods for Diabetes Mellitus: Comparative Effectiveness
Keywords: knowledge gaps | future research needs | diabetes | studies | characteristics | populations | outcomes
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