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External-Beam Radiation Therapy for Head and Neck Cancer

Presentation: Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Keywords: 2DRT | 3DCRT | head and neck cancer | IMRT | proton beam therapy | treatment | radiotherapy
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Treatment Planning

Presentation: Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Keywords: 2DRT | 3DCRT | head and neck cancer | IMRT | planning | treatment | radiotherapy
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Two-Dimensional Radiation Therapy and Three-Dimensional Conformal Radiation Therapy

Presentation: Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Keywords: radiotherapy | head and neck cancer | treatment | 2DRT | 3DCRT | planning
This slide includes a table with two columns and four rows. Column 1, row 1: potential advantages. Column 2, row 1: potential disadvantages.Column 1, row 2: Higher dose delivered to tumor. Column 2, row 2: Higher total body dose. Column 1, row 3: Sparing of normal, surrounding tissue from radiation damage. Column 2, row 3: Increased risk of marginal miss and dose perturbation. Column 1, row 4: Decreased toxicity. Column 2, row 4: time and expense. A definition of abreviations is included on the slide: IMRT = intensity-modulated radiation therapy; 2DRT = two-dimensional radiation therapy; 3DCRT = three-dimensional conformal radiation therapy. A footnote includes the following references: (1) Ballivy O, Santamaria RG, Borbalas AL, et al. Clinical application of intensity-modulated radiotherapy for head and neck cancer. Clin Transl Oncol 2008;10:407-14; (2) Burri MK, Bevan A, Roach M III. Advances in radiation therapy: conventional to 3D, to IMRT, to 4D, and beyond. CA Cancer J Clin 2005;55:117-34; (3) Mendenhall WM, Amdur RJ, Palta JR. Intensity-modulated radiotherapy in the standard management of head and neck cancer: promises and pitfalls. J Clin Oncol 2006;24:2618-23; (4) Samson DJ, Ratko TA, Rothenberg BM, et al. Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer, Comparative Effectiveness Review No. 20 (Prepared by the Blue Cross and Blue Shield Association Technology Evaluation Center Evidence-based Practice Center under Contract No. 290-02-0026). Rockville, MD: Agency for Healthcare Research and Quality; May 2010. AHRQ Publication No. 10-EHC014-EF. Available at: http://www.effectivehealthcare.ahrq.gov/index.cfm/search-for-guides-reviews-and-reports/?pageaction=displayproduct&productID=447.
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Potential Advantages and Disadvantages of IMRT When Compared With 2DRT and 3DCRT

Presentation: Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Keywords: 2DRT | 3DCRT | adverse events | head and neck cancer | IMRT | outcomes | safety | treatment | radiotherapy
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Proton Beam Therapy

Presentation: Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Keywords: head and neck cancer | planning | proton beam therapy | treatment | radiotherapy
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Interventions of Interest

Presentation: Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Keywords: comparative effectiveness review | radiotherapy | head and neck cancer | 2DRT | 3DCRT | IMRT | proton beam therapy
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Clinical Questions Addressed by the Comparative Effectiveness Review of Radiotherapy for Head and Neck Cancer

Presentation: Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Keywords:  | 2DRT | 3DCRT | adverse events | experience | head and neck cancer | IMRT | outcomes | proton beam therapy | quality of life | radiotherapy | survival | tumor control | comparative effectiveness
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Planned Comparisons

Presentation: Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Keywords: 2DRT | 3DCRT | head and neck cancer | IMRT | proton beam therapy | radiotherapy | comparative effectiveness
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Clinical Bottom Line: Comparative Evidence for 2DRT, 3DCRT, and IMRT

Presentation: Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Keywords: 2DRT | 3DCRT | adverse events | head and neck cancer | IMRT | outcomes | quality of life | radiotherapy | survival | tumor control | xerostomia | comparative effectiveness
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Clinical Bottom Line: Comparative Evidence for 2DRT, 3DCRT, and IMRT (continued)

Presentation: Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Keywords: 2DRT | 3DCRT | experience | head and neck cancer | IMRT | outcomes | quality of life | radiotherapy | treatment | xerostomia | comparative effectiveness
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Clinical Bottom Line: Comparative Evidence for Proton Beam versus 2DRT, 3DRT, and IMRT

Presentation: Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Keywords: 2DRT | 3DCRT | adverse events | experience | head and neck cancer | IMRT | outcomes | proton beam therapy | quality of life | radiotherapy | survival | treatment | tumor control | comparative effectiveness
This slide includes a table with two columns and four rows. Column 1, row 1: comparison. Column 2, row 1: evidence on tumor control or survival. Column 1, row 2: IMRT vs. 3DCRT. Column 2, row 2: insufficient. Column 1, row 3: IMRT vs. 2DRT. Column 2, row 3: insufficient. Column 1, row 4: 2DRT vs. 3DCRT. Column 2, row 4: insufficient. There is a footnote at the bottom of the slide that includes the following reference: Samson DJ, et al. AHRQ Comparative Effectiveness Review No. 20. Available at: http://www.effectivehealthcare.ahrq.gov/index.cfm/search-for-guides-reviews-and-reports/ ?pageaction=displayproduct&productID=447.
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Comparative Effectiveness Regarding Improved Tumor Control or Survival

Presentation: Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Keywords: 3DCRT | head and neck cancer | IMRT | outcomes | quality of life | radiotherapy | tumor control | comparative effectiveness
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