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Effectiveness of Recombinant Human Growth Hormone (rhGH) in the Treatment of Patients with Cystic Fibrosis

Authors: Christopher M. Oermann, MD and C. Michael White, PharmD, PCP, FCCP

Slides: 1–12 of 37

Effectiveness of Recombinant Human Growth Hormone (rhGH) in the Treatment of Patients
With Cystic Fibrosis Prepared for: Agency for Healthcare Research and Quality (AHRQ) (www.ahrq.gov)

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Effectiveness of Human Growth Hormone (rhGH) in the Treatment of Patients with Cystic Fibrosis

Keywords: cystic fibrosis | human growth hormone | CF | rhGH | recombinant human growth hormone | HGH

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Outline of Material

Keywords: CF | HGH | cystic fibrosis | human growth hormone | recombinant human growth hormone | rhGH

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Health Impact of Cystic Fibrosis in the United States

Keywords: cystic fibrosis | health impact | incidence | genetic disease | childhood | CF | rhGH | recombinant human growth hormone | human growth hormone | HGH

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Characteristics of CF: Origin of the Disease

Keywords: CFTR | CF transmembrane conductance regulator | gene | cystic fibrosis | CF | rhGH | recombinant human growth hormone | human growth hormone | HGH

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Clinical Features of Cystic Fibrosis

Keywords: pulmonary | disease | pancreatic | insufficiency | nutritional | deficiency | malnutrition | CF-related diabetes | diabetes | cystic fibrosis | CF | rhGH | recombinant human growth hormone | human growth hormone | HGH

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Rationale for Use of Recombinant Human Growth Hormone (rhGH) in Patients With CF

Keywords: nutrition | nutritional | deficiencies | deficiency | malnutrition | anabolic | cystic fibrosis | CF | rhGH | recombinant human growth hormone | human growth hormone | HGH

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Approved Therapeutic Uses of rhGH

Keywords: indications | cystic fibrosis | CF | rhGH | recombinant human growth hormone | human growth hormone | HGH

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Agency for Healthcare Research and Quality (AHRQ) Comparative Effectiveness Review (CER) Development

Keywords: systematic review | comparative effectiveness | cystic fibrosis | CF | rhGH | recombinant human growth hormone | human growth hormone | HGH

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Clinical Questions Addressed by the CER (1)

Keywords: intermediate outcomes | health outcomes | pulmonary function | body composition | bone mineralization | pulmonary exacerbation | mortality risk | health related quality of life | HRQoL | QoL | quality of life | cystic fibrosis | CF | rhGH | recombinant human growth hormone | human growth hormone | HGH

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Clinical Questions Addressed by the CER (2)

Keywords: CFRD | cystic fibrosis-related diabtes | CF-related diabetes | cystic fibrosis | CF | rhGH | recombinant human growth hormone | human growth hormone | HGH

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Rating the Strength of Evidence From the CER: A Modification of the GRADE Methodology

Keywords: CF | HGH | human growth hormone | recombinant human growth hormone | rhGH | Strength of Evidence | cystic fibrosis

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Outcomes of Interest in Studies of rhGH Treatment of Patients With CF

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