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Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Testing for the Evaluation of Musculoskeletal Complaints in Pediatric Populations

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Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Testing for the Evaluation of Musculoskeletal Complaints in Pediatric Populations

Keywords: research evidence | comparative effectiveness review
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Outline of Material

Keywords: comparative effectiveness review
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Background: Musculoskeletal Pain

Keywords: musculoskeletal pain | children | clinical characteristics | stiffness | joint swelling | malar rash | cytopenia | pediatric rheumatic condition
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Background: Causes of Musculoskeletal Pain

Keywords: musculoskeletal pain | nonrheumatic cause | sprain | strain | overuse | normal body growth | rheumatic cause | juvenile idiopathic arthritis | pediatric systemic lupus erythematosus | spondyloarthropathy | enthesitis-related arthritis | juvenile ankylosing spondylitis | reactive arthritis | acute rheumatic fever | Henoch-Schönlein purpura
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Background: Juvenile Idiopathic Arthritis

Keywords: juvenile idiopathic arthritis | chronic inflammatory disease | disease progression | cartilage | bone | soft tissue | severe disability | functional loss | organ failure | death
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Background: Pediatric Lupus Erythematosus

Keywords: pediatric systemic lupus erythematosus | autoimmune disease | inflammation | blood vessels | connective tissues | organs | incidence | prevalence | disease progression | immunosuppression
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Background: Using Serological Tests To Diagnose Musculoskeletal Pain

Keywords: musculoskeletal pain | diagnosis | patient history | physical examination | pain pattern | serological tests | antinuclear antibody | rheumatoid factor | cyclic-citrullinated peptide
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Background: Antinuclear Antibody Test

Keywords: antinuclear antibody test | ANA testing | autoimmune conditions | systemic lupus erythematosus | Sjögrens syndrome | systemic sclerosis | indirect immunofluorescence | enzyme immunoassay | ELISA
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Background: Rheumatoid Factor Test

Keywords: rheumatoid factor test | autoantibodies | Fc fragment | immunoglobulin G | IgG | 19S IgM-RF isotope | rheumatoid arthritis | juvenile idiopathic arthritis
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Background: Cyclic-Citrullinated Peptide Antibody Test

Keywords: autoantibodies | inflammatory arthritis | juvenile idiopathic arthritis | rheumatoid arthritis | cyclic-citrullinated peptide antibody test
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Agency for Healthcare Research and Quality Comparative Effectiveness Review (CER) Development

Keywords: evidence synthesis | systematic review | comparative effectiveness review
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Clinical Questions Addressed by the CER (1 of 3)

Keywords: key questions | clinical questions | prevalence | incidence | natural history | musculoskeletal pain | children | adolescents
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