Skip Navigation
Department of Health and Human Services www.hhs.gov
 
Slide Tray
0 slides

Return to Slide Library

Slides

Add Search Results to Slide Tray Search:

"confidence"

Slides: 1–12 of 124

Considerations for Observational Comparative Effectiveness Research Study Size Planning

Applicability of a Body of Evidence. Applicability of a body of evidence is not the same as applicability of individual studies. A collection of studies may provide broad applicable evidence even if individual studies do not. Consistency of study results across different populations and settings increases confidence in the applicability of the results. Applicability depends on context and cannot be assessed with a simple rating scale. There are no empiric data validating any scoring system for applicability.

Applicability of a Body of Evidence

This slide presents two scenarios. In scenario 1, the studies are all clustered around higher age; whereas, in scenario 2, the studies are all dispersed across the continuum of age. Because the populations seen in actual clinical practice are mostly in the low-to-moderate age range, scenario 2 has greater applicability.

Which Series of Studies Has an Applicability Issue?

Strength of Evidence. Why should grading of the strength of evidence and assessment of applicability be carried out separately? A. Strength of evidence grading and applicability assessment are essentially the same. B. Studies using strong methods can show that an intervention is superior to a control therapy in a study population, but it may or may not work in actual practice. C. Strength of evidence grading is primarily associated with assessing the external validity, whereas applicability assessment is concerned with internal validity.

Strength of Evidence

Pages: [1] 2 3 4 5 6 7 8 9 10 11 Next