Staff information
Richard Smith
Biological Sciences Division
Battelle Fellow
Pacific Northwest National Laboratory
PO Box 999
MSIN: K8-98
Richland, WA 99352
509/371-6576
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Biography
Battelle Fellow and Chief Scientist within the Biological Sciences Division, Dr. Smith's research interests span development of advanced analytical methods and instrumentation, with particular emphasis on high-resolution separations and mass spectrometry, and their applications in biological and biomedical research. Over the last 15 years, much of Dr. Smith's research has centered on creating and applying new ultra-sensitive technologies to quantitatively probe entire proteomes expressed by cells, tissues, and organisms. More recently, these efforts have broadened to include development and application of highly sensitive, high-throughput technologies for measuring the metabolome, lipidome, and glycadome to augment systems biology research.
Dr. Smith also is Director of Proteome Research at PNNL, Director of the NIH Research Resource for Integrative Proteomics, an adjunct faculty member in the chemistry departments at Washington State and Utah State universities, and an affiliate faculty member at the University of Idaho. Dr. Smith completed his Ph.D. work in Physical Chemistry at the University of Utah. He is the author/co-author of more than 800 peer-reviewed journal articles and recipient of 43 patents.
Research Interests
- Development and application of advanced analytical methods and instrumentation, with particular emphasis on high resolution separations and mass spectrometry, and their applications in biological and biomedical research
- Development and application of new ultra-sensitive methods for quantitatively probing the entire array of proteins expressed by a cell, tissue or organism, i.e., their “proteomes”
- Increasing the throughput and sensitivity of proteomics and metabolomics measurements to augment systems biology research
Education and Credentials
- B.S., Chemistry, Lowell Technological Institute, University of Massachusetts
- Ph.D., Physical Chemistry, University of Utah
Affiliations and Professional Service
- American Chemical Society
- American Society for Mass Spectrometry
- American Association for the Advancement of Science (Fellow)
- Adjunct Professor, Department of Chemistry, Washington State University
- Affiliate Professor, Department of Chemistry, University of Idaho
- Adjunct Professor of Chemistry, University of Utah
Awards and Recognitions
- R&D Magazine 2010 Scientist of the Year
- Nine R&D 100 Awards:
- Ion Mobility Spectrometer on a Microchip (2010)
- Ultrasensitive Electrospray Ionization Mass Spectrometry Source and Interface (2009)
- Development of the FT-MS Proteome Express (2003)
- Electrodynamic Ion Funnel (1999)
- Rapid Microdialyzer (1998)
- MICLEAN/MICARE Process (1998)
- Rapid Expansion of Supercritical Fluid Solutions Process (1988)
- Capillary Electrophoresis-Electrospray Ionization-MS (1988). Named among top 40 R&D 100 Awards of all time.
- Development of Supercritical Fluid Chromatography-Mass Spectrometry (1983)
- Federal Laboratory Consortium Award for the Electrodynamic Ion Funnel (2004)
- Elected Fellow, American Association for the Advancement of Science (2007)
- Wiley Research Fellow, Environmental Molecular Sciences Laboratory
- Eastern Analytical Symposium Award for Outstanding Achievements in the Fields of Analytical Chemistry
- Elected to Washington State Academy of Sciences
- Gordon Battelle Prize for Scientific Discovery
- HUPO Discovery Award in Proteomic Sciences
- Editor-in-Chief, Journal of Proteomics & Bioinformatics
- Council of the Human Proteome Organization (HUPO) 2007-2010
- Scientific American 50--shared with Dr. Desmond Smith, University of California at Los Angeles, for their work on understanding the human brain (2007)
- 2003 ACS Award for Analytical Chemistry
- American Oil Chemists Society Award
- Battelle-Northwest Director's Award for Excellence
- AWU-DOE Distinguished Lecturer
- Battelle Inventor of the Year
- Pacific Northwest National Laboratory Mentor of the Year
- DOE Energy 100 Award
- ACS Award for Analytical Chemistry
- ICI List of most cited chemists
- Serves on nine scientific journal advisory boards