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Acceptable Substitutes for CFC-114 and CFC-11 in Chillers and Other Refrigerants
Substitutes are reviewed on the basis of ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptable and unacceptable substitutes are updated several times each year. A chronological list of SNAP updates is also available.
Note: SNAP-related information published in the Federal Register takes precedence over all information on this page.
| Substitute (Name Used in the Federal Register) | Trade Name | Retrofit/New |
|---|---|---|
| HCFC-22 | N | |
| HCFC-123 | N | |
| HCFC-124 | R,N | |
| HFC-134a | N | |
| HFC-227ea | N | |
| HFC-236fa | R,N | |
| Ammonia Vapor Compression | N | |
| Evaporative Cooling | N | |
| Desiccant Cooling | N | |
| Ammonia / Water Absorption | N | |
| Water / Lithium Bromide Absorption | N | |
| HFC-245fa | Genetron® 245fa | R, N |
| Hot Shot 2 | Hot Shot 2 | R |
Key: R = Retrofit Uses, N = New
Uses
| Substitutes (Name Used in the Federal Register) | Trade Name | Retrofit/New |
|---|---|---|
| HCFC-123 | R, N | |
| HCFC-22 | N | |
| HFC-134a | N | |
| HFC-227ea | N | |
| HFC-245fa | N | |
| Ammonia Vapor Compression | N | |
| Evaporative Cooling | N | |
| Desiccant Cooling | N | |
| Ammonia / Water Absorption | N | |
| Water / Lithium Bromide Absorption | N | |
| Hot Shot 2 | Hot Shot 2 | R |
| Trans-1-chloro-3,3,3-trifluoroprop-1-ene | Solstice 1233zd(E), Solstice N12 Refrigerant | N |
| HFO-1234ze | Solstice 1234ze | N |
Key: R = Retrofit Uses, N = New
Uses
Acceptable Substitutes for CFCs (class I ODS) in Reciprocating and Screw Chillers
| Substitute (Name Used in the Federal Register) | Trade Name | Refrigerant Being Replaced | Retrofit/ New |
|---|---|---|---|
| HCFC-22 | 12, 500 | N | |
| Ikon B | 12 | N | |
| THR-02 | 12 | N | |
| HFC-134a | 12, 500 | R, N | |
| HFC-227ea | 12, 500 | N | |
| R-401A, R-401B | MP-39, MP-66 | 12, 500 | R, N |
| R-411A, R-411B | 12, 500 | R, N | |
| Free Zone (HCFC Blend Delta) | Free Zone / RB-276 | 12, 500 | R, N |
| Freeze 12 | Freeze 12 | 12, 500 | R, N |
| FRIGC FR-12 (HCFC Blend Beta) | FRIGC FR-12 | 12, 500 | R, N |
| GHG-X4 | GHG-X4, Autofrost, Chill-it | 12, 500 | R, N |
| GHG-X5 | GHG-X5 | 12, 500 | R, N |
| G2018C | G2018C | 12, 500 | R, N |
| Hot Shot | Hot Shot, Kar Kool | 12, 500 | R, N |
| HCFC-22/HCFC-142b | 12 | R, N | |
| FOR12A | FOR12A | 12 | R, N |
| FOR12B | FOR12B | 12 | R, N |
| SP34E | SP34E | 12 | R, N |
| Evaporative/Desiccant Cooling | 12, 500 | N | |
| R-407C | Suva 407C, Klea 407C | 502 | R, N |
| R-420A | Choice R-420A | 12, 500 | R, N |
| R-422C | ICOR XLT1 | 502 | R, N |
| KDD6 | KDD6 | 12 | R, N |
| Hot Shot 2 | Hot Shot 2 | R | |
| HFO-1234ze | Solstice 1234ze | N |
Key: R = Retrofit Uses, N = New
Uses
Acceptable Substitutes for HCFCs (class II ODS) in Reciprocating and Screw Chillers
| Substitute (Name Used in the Federal Register) | Trade Name | Refrigerant Being Replaced | Retrofit/ New |
|---|---|---|---|
| THR-03 | 22 | N | |
| ISCEON 59, NU-22, R-417A | ISCEON 59, NU-22 | 22, blends containing 22 and/or 142b | R, N |
| R-410A | AZ-20, Suva 9100, Puron | 22 and blends containing HCFCs | N |
| R-410B | 22, blends containing 22 and/or 142b | N | |
| R-407C | Suva 9000, Klea 66 | 22 and blends containing HCFCs | R, N |
| R-507, R-507A | AZ-50 | 22 and blends containing HCFCs | N |
| Ammonia Vapor Compression With Secondary Loop | 22, blends containing 22 and/or 142b | N | |
| Ammonia Absorption | 22, blends containing 22 and/or 142b | N | |
| Evaporative Cooling | 22, blends containing 22 and/or 142b | N | |
| Desiccant Cooling | 22, blends containing 22 and/or 142b | N | |
| R-404A | HP62 | 22 and blends containing HCFCs | R, N |
| R-125/134a/600a (28.1/70.0/1.9) | NU-22 old composition | 22, blends containing 22 and/or 142b | R, N |
| RS-44 (2003 formulation) | RS-44 | 22, blends containing 22 and/or 142b | R, N |
| R-421A | Choice R421A | 22, blends containing 22 and/or 142b | R, N |
| R-422D | ISCEON MO29 | 22, blends containing 22 and/or 142b | R, N |
| R-424A | RS-44 | 22, blends containing 22 and/or 142b | R, N |
| KDD5, R-438A | ISCEON MO99 | 22, blends containing 22 and/or 142b | R, N |
| R-434A | RS-45 | 22, blends containing 22 and/or 142b | R, N |
| R-125/290/134a/600a (55.0/1.0/42.5/1.5) | ICOR AT-22 | 22, blends containing 22 and/or 142b | R, N |
| R-422B | XAC1, NU22B | 22, blends containing 22 and/or 142b | R, N |
| R-422C | XLT1 | 22, blends containing 22 and/or 142b | R, N |
| R-427A | Forane 427A | 22, blends containing 22 and/or 142b | R |
| HFC-134a | 22, blends containing 22 and/or 142b | R, N | |
| HFC-227ea | 22, blends containing 22 and/or 142b | N | |
| SP34E | SP34E | 22, blends containing 22 and/or 142b | R, N |
| Stirling cycle | 22, blends containing 22 and/or 142b | N | |
| Hot Shot 2 | Hot Shot 2 | HCFC-22 and HCFC blends, including those containing HCFC–22 and/or HCFC–142b | R |
| HFO-1234ze | Solstice 1234ze | 22, blends, containing 22 and/or 142b | N |
Key: R = Retrofit Uses, N = New
Uses
Acceptable Substitutes for CFC-12 & R-500 (class I ODS) in Centrifugal Chiller
| Substitute (Name Used in the Federal Register) | Trade Name | Refrigerant Being Replaced | Retrofit/ New |
|---|---|---|---|
| HCFC-22 | 12, 500 | N | |
| HCFC-123 | 12, 500 | N | |
| HFC-134a | 12, 500 | R, N | |
| Ikon A | 12 | R, N | |
| Ikon B | 12 | R, N | |
| HFC-227ea | 12, 500 | N | |
| R-406A | GHG | 12, 500 | R, N (R-500 only) |
| Free Zone (HCFC Blend Delta) | Free Zone / RB-276 | 12, 500 | R, N |
| Freeze 12 | Freeze 12 | 12, 500 | R, N |
| FRIGC FR-12 (HCFC Blend Beta) | FRIGC FR-12 | 12, 500 | R, N |
| GHG-X4 | GHG-X4, Autofrost, Chill-it | 12, 500 | R, N |
| GHG-X5 | GHG-X5 | 12, 500 | R, N |
| G2018C | G2018C | 12, 500 | R, N |
| Hot Shot | Hot Shot, Kar Kool | 12, 500 | R, N |
| HCFC-22/HCFC-142b | 12 | R, N | |
| R-420A | Choice R-420A | 12, 500 | R, N |
| FOR12A | FOR12A | 12 | R, N |
| FOR12B | FOR12B | 12 | R, N |
| Ammonia Vapor Compression With Secondary Loop | 12, 500 | N | |
| Evaporative/Desiccant Cooling | 12, 500 | N | |
| Ammonia / Water Absorption | 12, 500 | N | |
| Water / Lithium Bromide Absorption | 12, 500 | N | |
| THR-02 | THR-02 | 12 | N |
| ISCEON 39TC | ISCEON 39TC | 12 | R, N |
| Hot Shot 2 | Hot Shot 2 | 12,500 | R |
| HFO-1234ze | Solstice 1234ze | 12,500 | N |
Key: R = Retrofit Uses, N = New
Uses
Acceptable Substitutes for HCFCs (class II ODS) in Centrifugal Chillers
| Substitute (Name Used in the Federal Register) | Trade Name | Refrigerant Being Replaced | Retrofit/ New |
|---|---|---|---|
| THR-03 | 22 | N | |
| ISCEON 59, NU-22, R-417A | ISCEON 59, NU-22 | 22, blends containing 22 and/or 142b | R, N |
| R-410A | AZ-20, Suva 9100, Puron | 22 and blends containing HCFCs | N |
| R-410B | 22, blends containing 22 and/or 142b | N | |
| R-407C | Suva 9000, Klea 66 | 22 and blends containing HCFCs | R, N |
| R-507, R-507A | AZ-50 | 22 and blends containing HCFCs | N |
| Ammonia Vapor Compression With Secondary Loop | 22, blends containing 22 and/or 142b | N | |
| Ammonia Absorption | 22, blends containing 22 and/or 142b | N | |
| Evaporative Cooling | 22, blends containing 22 and/or 142b | N | |
| Desiccant Cooling | 22, blends containing 22 and/or 142b | N | |
| R-404A | HP62 | 22 and blends containing HCFCs | R, N |
| R-125/134a/600a (28.1/70.0/1.9) | NU-22 old composition | 22, blends containing 22 and/or 142b | R, N |
| RS-44 (2003 formulation) | RS-44 | 22, blends containing 22 and/or 142b | R, N |
| R-421A | Choice R421A | 22, blends containing 22 and/or 142b | R, N |
| R-422D | ISCEON MO29 | 22, blends containing 22 and/or 142b | R, N |
| R-424A | RS-44 | 22, blends containing 22 and/or 142b | R, N |
| KDD5, R-438A | ISCEON MO99 | 22, blends containing 22 and/or 142b | R, N |
| R-434A | RS-45 | 22, blends containing 22 and/or 142b | R, N |
| R-125/290/134a/600a (55.0/1.0/42.5/1.5) | ICOR AT-22 | 22, blends containing 22 and/or 142b | R, N |
| HFC-245fa | Genetron® 245fa | 22, blends containing 22 and/or 142b | R, N |
| R-422B | XAC1, NU22B | 22, blends containing 22 and/or 142b | R, N |
| R-422C | XLT1 | 22, blends containing 22 and/or 142b | R, N |
| HFC-134a | 22, blends containing 22 and/or 142b | R, N | |
| HFC-227ea | 22, blends containing 22 and/or 142b | N | |
| R-423A | ISCEON 39TC | 22, blends containing 22 and/or 142b | R, N |
| Stirling cycle | 22, blends containing 22 and/or 142b | N | |
| Hot Shot 2 | Hot Shot 2 | 22, blends containing 22 and/or 142b | R |
| Trans-1-chloro-3,3,3-trifluoroprop-1-ene | Solstice 1233zd(E), Solstice N12 Refrigerant | 123 | N |
| HFO-1234ze | Solstice 1234ze | 123 | N |
Key: R = Retrofit Uses, N = New
Uses