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"Evidence-based Practice Center"

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Clostridium difficile Infections: Diagnosis, Treatment, and Prevention

Analgesics for Osteoarthritis—An Update

Why Use Analytic Frameworks? To provide clinical, biological, or health services underpinnings for the mechanism of action. To clarify implicit assumptions. To identify logical flaws as key questions are developed. To provide a starting point for discussions with key informants. To identify distinct bodies of evidence to be included in the review.

Why Use Analytic Frameworks?

Depicting Essential Components: An Example. Graphical chain of logic: Arrows - Linkages, Preventive service or treatment, Questions. Dotted lines – Associations. Rectangles - Intermediate outcomes, Rounded corners; Health states, Square corners. Curved arrows - Lead to ovals, Harms

Depicting Essential Components: An Example

This figure shows a blank portion of an analytic framework with a box with rounded edges connected to another box with rounded edges, which is then connected to a sharp-edged box. These represent two intermediate outcomes leading to a final health outcome. An arrow leads down from the figure to an oval shape, representing a potential harm. The framework also has an arrow leading directly form the first box to the final health outcomes box, indicating that there may also be a direct relationship.

Key Research Questions

This presentation was prepared by Melissa L. McPheeters, Ph.D., M.P.H., a member of the Vanderbilt University Evidence-based Practice Center.
The module is based on an update of chapter 2 in version 1.0 of the Methods Guide for Comparative Effectiveness Reviews (available at: http://www.effectivehealthcare.ahrq.gov/ehc/products/60/294/2009_0805_principles1.pdf).

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Angiotensin-Converting Enzyme Inhibitors (ACEIs), Angiotensin II Receptor Antagonists (ARBs), or Direct Renin Inhibitors (DRI) for Adults with Hypertension

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