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Acceptable Substitutes in Very Low Temperature Refrigeration
Substitutes are reviewed on the basis of ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptable and unacceptable substitutes are updated several times each year. A chronological list of SNAP updates is also available.
Unacceptable substitutesNote: SNAP-related information published in the Federal Register takes precedence over all information on this page.
Acceptable Substitutes for CFCs (class I ODS) in Very Low Temp Refrigeration
| Substitute (Name Used in the Federal Register) | Trade Name | Refrigerant Being Replaced | Retrofit/ New |
|---|---|---|---|
| HFC-23 | 12, 13, 13B1, 503 | R, N | |
| R-403B | ISCEON 69-L | 13, 13B1, 503 | R, N
Note: R-403B is unacceptable as a substitute for R-502. |
| R-508A (PFC Blend Alpha) | Klea 5R3 | 13, 13B1, 503 | R, N |
| R-508B | Suva 95 | 13, 13B1, 503 | R, N |
| R-744 (Carbon Dioxide, CO2) | 13, 13B1, 503 | R, N | |
| NARM-502 | 13, 13B1, 503 | R, N | |
| HFE-7100 as a secondary heat transfer fluid in not-in-kind systems | 13, 13B1, 503 | N | |
| HFE-7200 as a secondary heat transfer fluid in not-in-kind systems | 13, 13B1, 503 | N | |
| PFC-330ST, PFC-550HC, PFC-660HC, PFC-1100HC, PFC-1100LT, PGC-100, PGC-150, PFC-331ST, PFC-551HC, PFC-661HC, PFC-1101HC, and PGC-151 | PFC-330ST, PFC-550HC, PFC-660HC, PFC-1100HC, PFC-1100LT, PGC-100, PGC-150, PFC-331ST, PFC-551HC, PFC-661HC, PFC-1101HC, and PGC-151 | 13, 113, 114 and blends thereof | R, N |
| PFC-1102HC, PFC-662HC, PFC-552HC, and FLC-15 | PFC-1102HC, PFC-662HC, PFC-552HC, and FLC-15 | 13, 113, 114, blends thereof | N |
| ISCEON 89 | ISCEON 89 | R-13B1 | R, N |
| R-422C | ICOR XLT1 | 502 | R, N |
| HFC-245fa | Genetron® 245fa | 11, 114 | R, N |
| R-507A | AZ-50, R-507A | 13B1 | R |
Key: R = Retrofit Uses, N = New
Uses
Acceptable Substitutes for HCFCs (class II ODS) in Very Low Temp Refrigeration
| Substitute (Name Used in the Federal Register) | Trade Name | Refrigerant Being Replaced | Retrofit/ New |
|---|---|---|---|
| R-410A | AZ-20 | 22 and HCFC blends | N |
| R-404A | HP62 | 22 and HCFC blends | R, N |
| R-407C | Suva 9000, KLEA 66 | 22 and HCFC blends | R, N |
| Hydrofluoroether-7000 | HFE-7000 | 123 | R, N |
| HFC-245fa | Genetron® 245fa | 141b | N |
| R-125/290/134a/600a (55.0/1.0/42.5/1.5) | ICOR AT-22 | 22, blends containing 22 and/or 142b | R, N |
| R-422B | XAC1, NU-22B | 22, blends containing 22 and/or 142b | R, N |
| R-422 | XLT1 | 22, blends containing 22 and/or 142b | R, N |
| R-744 (Carbon Dioxide, CO2) | 22, blends containing 22 and/or 142b | N | |
| HFE-7100 and HFE-7200 as secondary heat transfer fluid in not-in-kind systems | 22, blends containing 22 and/or 142b | N |