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"future research"

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Gaps in Knowledge

Presentation: Clostridium difficile Infections: Diagnosis, Treatment, and Prevention
Keywords: gaps in knowledge | diagnostic assays | prevention strategies | probiotics | prebiotics | fecal transplant | definitions
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Overall Conclusions

Presentation: Adjunctive Devices for Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention
Keywords: conclusions | ST-segment elevation myocardial infarction | STEMI | percutaneous coronary intervention | PCI | catheter aspiration | mechanical thrombectomy | future research
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Gaps in Knowledge

Presentation: Adjunctive Devices for Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention
Keywords: gaps in knowledge | acute coronary syndrome | ACS | percutaneous coronary intervention | PCI | catheter aspiration | mechanical thrombectomy | future research | final health outcomes
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Outline of Material

Presentation: Analgesics for Osteoarthritis—An Update
Keywords: outline | background | comparative effectiveness review
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Knowledge Gaps and Future Research Needs (1 of 3)

Presentation: Analgesics for Osteoarthritis—An Update
Keywords: knowledge gaps | future research | CV risks | GI benefits | COX-2 selective NSAIDs
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Knowledge Gaps and Future Research Needs (2 of 3)

Presentation: Analgesics for Osteoarthritis—An Update
Keywords: knowledge gaps | future research | COX-2 inhibitors | risks | CV safety | GI safety | nonselective NSAIDs | aspirin | salsalate | acetaminophen | alternative dosing
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Knowledge Gaps and Future Research Needs (3 of 3)

Presentation: Analgesics for Osteoarthritis—An Update
Keywords: knowledge gaps | future research | glucosamine | benefits | comparative risks | CV adverse effects | GI adverse effects | topical NSAIDs
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Gaps in Knowledge

Presentation: Angiotensin-Converting Enzyme Inhibitors (ACEIs), Angiotensin II Receptor Antagonists (ARBs), or Direct Renin Inhibitors (DRI) for Adults With Hypertension
Keywords: gaps in knowledge | future research | subgroups | clinical trials
In the trials that this Comparative Effectiveness Review (CER) was based on, only a few had detailed subanalyses of disease or patient characteristics that correlated with the improved patient outcomes derived from adding an angiotensin-converting enzyme inhibitor (ACEI) or an angiotensin II receptor blocker (ARB) to the treatment regimen of patients with stable ischemic heart disease (IHD) and preserved left ventricular systolic function (LVSF). In addition, harms data were not available for many of the subpopulation analyses. Therefore, this evidence should be used mainly to generate hypotheses. From the subpopulation analyses, it is clear that more evidence is needed to determine whether there are patient characteristics or clinical factors that can determine whether patients with stable IHD and preserved LVSF will benefit more or less from the addition of an ACEI or an ARB to their standard therapies. Gender, diabetic status, the presence or absence of hypertension, the presence or absence of specific concomitant therapies, or a patient’s history of revascularization are all potential factors that may play a role in responsiveness to ACEIs or ARBs. Additional meta-analyses and clinical trials are needed to determine the benefits and harms of ACEIs and ARBs to these different subpopulations of patients.
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Gaps in Knowledge About ACEIs and ARBs as Treatment for Stable Ischemic Heart Disease With Preserved Left Ventricular Systolic Function

Presentation: Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors and/or Angiotensin II Receptor Blockers Added to Standard Medical Therapy for Treating Patients With Stable Ischemic Heart Disease and Preserved Left Ventricular Systolic Function
Keywords: angiotensin II-receptor blocker | angiotensin-converting enzyme inhibitor | comparative effectiveness | future research | stable ischemic heart disease | gaps in knowledge
Additional Off-Label Uses of rFVIIa Requiring Future Research Surgery-related uses include: management of abdominal aortic aneurysm (with and without surgical intervention), pediatric cardiac surgery, vascular surgeries (not related to abdominal aortic aneurysm), and surgical procedures beyond cardiac and vascular surgery.
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Additional Off-Label Uses of rFVIIa Requiring Future Research

Presentation: Comparative Effectiveness of In-Hospital Use of Recombinant Factor VIIa for Off-Label Indications vs. Usual Care
Keywords: comparative effectiveness | recombinant factor VIIa | off-label | future research
Additional Off-Label Uses of rFVIIa Requiring Future Research Medical conditions include: cancer-related conditions, gastrointestinal bleeding not related to liver disease, hematopoietic stem cell transplantation, liver disease (other than transplantation), neonatal conditions (beyond cardiac surgery), obstetrical conditions, primary clotting disorders (other than hemophilia), pulmonary conditions (e.g., pulmonary hemorrhage, pulmonary transplantation), and secondary clotting disorders (e.g., complications of warfarin anticoagulation).
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Additional Off-Label Uses of rFVIIa Requiring Future Research

Presentation: Comparative Effectiveness of In-Hospital Use of Recombinant Factor VIIa for Off-Label Indications vs. Usual Care
Keywords: comparative effectiveness | recombinant factor VIIa | off-label | future research
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Outline of Material

Presentation: Comparative Effectiveness of Management Strategies for Adults With Gastroesophageal Reflux Disease: An Update
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