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"precision"

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Outline of Material

Presentation: Study Size Planning for Observational Comparative Effectiveness Research
Keywords: outline | comparative effectiveness research | key considerations | study size planning
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Considerations for Observational Comparative Effectiveness Research Study Size Planning

Presentation: Study Size Planning for Observational Comparative Effectiveness Research
Keywords: observational comparative effectiveness research | study size
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Considerations That Differ From Nonrandomized Studies

Presentation: Study Size Planning for Observational Comparative Effectiveness Research
Keywords: considerations | nonrandomized study | randomized controlled trial
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Summary Checklist (1 of 2)

Presentation: Study Size Planning for Observational Comparative Effectiveness Research
Keywords: summary checklist | study size | statistical methods
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Summary Checklist (2 of 2)

Presentation: Study Size Planning for Observational Comparative Effectiveness Research
Keywords: summary checklist | study size | statistical methods
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Overview: Conclusions

Presentation: Clostridium difficile Infections: Diagnosis, Treatment, and Prevention
Keywords: conclusions | diagnostic assays | patient outcomes | prevention | treatment | overview
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Results of Direct Comparisons of Available Diagnostic Assays

Presentation: Clostridium difficile Infections: Diagnosis, Treatment, and Prevention
Keywords: C. difficile Infection (CDI) | immunoassays | results | sensitivity | specificity | toxin gene detection | diagnostic assays
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Background: Glucosamine and Chondroitin

Presentation: Analgesics for Osteoarthritis—An Update
Keywords: chondroitin | glucosamine | background
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Rating the Strength of Evidence From the CER

Presentation: Analgesics for Osteoarthritis—An Update
Keywords: comparative effectiveness | strength of evidence | systematic review | methods
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Rating the Strength of Evidence From the Comparative Effectiveness Review

Presentation: Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Testing for the Evaluation of Musculoskeletal Complaints in Pediatric Populations
Keywords: comparative effectiveness review | strength of evidence | evidence grade | risk of bias | consistency | directness | precision | Quality Assessment of Diagnostic Accuracy Studies | QUADAS
Consider the Contribution of an Individual Study to the Body of Evidence. This slide shows how characteristics of the individual study relate to domains evaluating the strength of the body of evidence. Each characteristic of the individual study is linked by an arrow to a domain for the strength of the body of evidence. The slide shows that the quality or internal validity of a study (i.e., limitations of study design and conduct) is one of several ways in which an individual study can contribute to the body of evidence. When evaluating the strength of the entire body of evidence, the quality of the study and the type of design influence the evaluation of the risk of bias for the entire body of evidence. The direction and magnitude of the results influence considerations of consistency of the body of evidence. The size of the study could result in nonsystematic or random error; it influences considerations of precision of the body of evidence. The relevance of the results to the key questions influences the evaluation of directness of the body of evidence. The relevance of the study sample to the population(s) of interest influences the assessment of applicability or generalizability of the body of evidence.
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Consider the Contribution of an Individual Study to the Body of Evidence

Presentation: Assessing the Quality of Individual Studies
Keywords: internal validity | study design | body of evidence | key questions | applicability | generalizability
Arrive at a Comprehensive Judgment of Quality. After assessment of individual criteria, assign ratings of “good,” “fair,” or “poor” (attributes described in later slides). Assess quality for each outcome of interest. Base ratings on the evaluation of likely effect of design or execution flaws on internal validity, rather than a nominal failure to meet every quality criterion. Adjudicate differences between raters in a transparent manner when two raters independently assess overall quality.
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Arrive at a Comprehensive Judgment of Quality

Presentation: Assessing the Quality of Individual Studies
Keywords: quality
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