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Second-Generation Antidepressants for Treating Adult Depression—An Update

Authors: Rayan K. Al Jurdi, MD and Linda J. Lux, MPA

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Background: Prevalence of Depressive Disorders

Depressive disorders such as major depressive disorder (MDD), dysthymia, and subsyndromal depression may be serious, disabling illnesses. MDD affects more than 16 percent of adults at some point during their lifetimes. In 2000, the economic burden of depressive disorders in the United States was estimated to be $83.1 billion. Likely, this number has increased during the past 10 years. More than 30 percent of these costs are attributable to direct medical expenses.

Keywords: prevalence | depressive disorders | medical expenses | dysthymia | subsyndromal depression

References:

American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Text rev. Washington, DC: American Psychiatric Association; 2000.
Birnbaum HG, Ben-Hamadi R, Greenberg PE, et al. Determinants of direct cost differences among US employees with major depressive disorders using antidepressants. Pharmacoeconomics 2009;27(6):507-17. PMID: 19640013.
Greenberg PE, Kessler RC, Birnbaum HG, et al. The economic burden of depression in the United States: how did it change between 1990 and 2000? J Clin Psychiatry 2003 Dec;64(12):1465-75. PMID: 14728109.
Kessler RC, Berglund P, Demler O, et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 2003;289(23):3095-105. PMID: 12813115.