Addition of Ezetimibe (Ezetrol®) to Ongoing Therapy With Rosuvastatin (Crestor®) in HIV Positive Patients Not Reaching Cholesterol Targets
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This study involves comparing the effectiveness of treatments in HIV positive patients who may be predisposed to heart attack or stroke. The investigators will evaluate the effectiveness of two drugs, often prescribed by doctors to these patients, at lowering cholesterol and thereby making the patient less them less vulnerable to suffering a heart attack or stroke. The investigators believe that the addition of a second drug, from a different class of cholesterol lowering medications, will improve the outcome of the patients by lowering cholesterol.
Condition | Intervention |
---|---|
Hypercholesterolemia HIV Infections |
Drug: Ezetimibe Drug: Rosuvastatin (standard care) |
Study Type: | Interventional |
Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Treatment |
Official Title: | A Prospective, Randomized Study to Determine the Effect of Ezetimibe in Addition to Rosuvastatin on Lipids in Participants With the Hypercholesterolemia Associated With HIV Antiretroviral Therapy |
- The primary endpoint is the difference in final value of serum apolipoprotein B between participants treated with rosuvastatin versus participants treated with both rosuvastatin and ezetimibe. [ Time Frame: 3 months from baseline ] [ Designated as safety issue: No ]
- Percent change in apolipoprotein B, percent and absolute change total cholesterol, LDL, HDL, triglycerides, apolipoprotein A1, apolipoproteinB/apoliporoteinA1 ratio and C-reactive protein [ Time Frame: 3 months from baseline ] [ Designated as safety issue: No ]
- Assessment of safety parameters, specifically incidence of complications as measured by an increase in AST &/or ALT ≥3-fold ULN & a CK ≥10-fold ULN [ Designated as safety issue: Yes ]
Estimated Enrollment: | 50 |
Study Start Date: | June 2009 |
Arms | Assigned Interventions |
---|---|
Active Comparator: Ezetimibe
10mg/day ezetimibe in addition to ongoing rosuvastatin treatment (10mg/day)
|
Drug: Ezetimibe
10mg/day ezetimibe in addition to ongoing rosuvastatin treatment (10mg/day)- tablet, orally, 10mg/day for 12 weeks
Other Name: Ezetrol
|
Active Comparator: Standard Care
Increased dose of rosuvastatin to 20mg/day
|
Drug: Rosuvastatin (standard care)
Increased dose of rosuvastatin to 20mg/day
Other Name: Crestor
|
Detailed Description:
This study seeks to determine whether HIV positive patients who have suboptimal lipids and/or are not reaching specified lipid targets will benefit from the addition of a second lipid lowering drug (ezetimibe) to existing lipid lowering therapy with a statin (specifically rosuvastatin) versus increasing the dose of the ongoing statin in terms of improvements in serum lipid parameters namely total cholesterol, LDL, HDL, triglycerides and apolipoprotein B100 (apoB), apolipoprotein A1 (apoA1), apoB/apoA1 ratio.
The target population will be HIV+ patients with hypercholesterolemia due to highly active antiretroviral therapy, the study will have a randomized, parallel design. Sample size will be 50 patients already taking 10 mg of rosuvastatin who are not reaching lipid targets to receive either an increased dose of rosuvastatin (20mg) or to receive 10mg ezetimibe in addition to their ongoing rosuvastatin therapy. There will be 25 patients randomized to each group.
At baseline serum samples will be obtained and tested for serum triglycerides, total cholesterol, HDL, total cholesterol:HDL ratio, apoB, apoA1, apoB/apoA1 ratio, liver transaminases (AST and ALT), CK, thyroid stimulating hormone, creatinine and fasting blood glucose.
After 12 weeks of therapy serum samples will once again be obtained and tested for serum triglycerides, total cholesterol, HDL, total cholesterol:HDL ratio, apolipoprotein B100, liver transaminases (AST and ALT), CK, thyroid stimulating hormone, creatinine and fasting blood glucose.
The primary hypothesis is that the combination of rosuvastatin and ezetimibe will lower serum apolipoprotein B100/apolipoprotein A1 ratio more so than an increased dose of rosuvastatin alone, in participants with mixed dyslipidemia associated with HIV therapy.
Secondarily we believe the combination of rosuvastatin and ezetimibe will lower the concentrations of serum cholesterol, LDL-cholesterol, triglycerides, apolipoprotein B100 and C-reactive protein more so than an increased dose of rosuvastatin alone, and that there will be no increase in side effects when administered to participants with mixed dyslipidemia associated with HIV therapy.
![](https://webarchive.library.unt.edu/web/20130305102335im_/http://clinicaltrials.gov/ct2/html/images/frame/triangle.gif)
Ages Eligible for Study: | 19 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- HIV positive
- currently taking 10mg of rosuvastatin
- recent (within three months) fasting lipid profile in which the serum total cholesterol to HDL ratio is >5.0
Exclusion Criteria:
- Previous adverse reaction to ezetimibe
- taken ezetimibe within 30 days of starting the study
- history of vascular disease
- allergic reaction or muscle problems while taking any statin
- currently taking other lipid lowering medications (i.e. a fibrates or cholestyramine)
![](https://webarchive.library.unt.edu/web/20130305102335im_/http://clinicaltrials.gov/ct2/html/images/frame/triangle.gif)
Contact: Kevin Johns | (604) 682-2344 ext 63139 | kevinwjohns@gmail.com |
Canada, British Columbia | |
St. Paul's Hospital HIV Immunodeficiency/Metabolic Clinic | Recruiting |
Vancouver, British Columbia, Canada, V6Z 1Y6 | |
Contact: Kevin Johns (604) 682-2344 ext 63139 kevinwjohns@gmail.com |
Principal Investigator: | Greg Bondy, MD | University of British Columbia |
![](https://webarchive.library.unt.edu/web/20130305102335im_/http://clinicaltrials.gov/ct2/html/images/frame/triangle.gif)
No publications provided
Responsible Party: | University of British Columbia |
ClinicalTrials.gov Identifier: | NCT00908011 History of Changes |
Other Study ID Numbers: | H08-00287 |
Study First Received: | May 21, 2009 |
Last Updated: | November 21, 2011 |
Health Authority: | Canada: Health Canada |
Keywords provided by University of British Columbia:
Hypercholesterolemia HIV Ezetimibe Statin Apolipoprotein B100/Apolipoprotein A1 ratio |
Additional relevant MeSH terms:
HIV Infections Acquired Immunodeficiency Syndrome Hypercholesterolemia Lentivirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Immunologic Deficiency Syndromes Immune System Diseases Slow Virus Diseases Hyperlipidemias Dyslipidemias |
Lipid Metabolism Disorders Metabolic Diseases Rosuvastatin Ezetimibe Hydroxymethylglutaryl-CoA Reductase Inhibitors Anticholesteremic Agents Hypolipidemic Agents Antimetabolites Molecular Mechanisms of Pharmacological Action Pharmacologic Actions Enzyme Inhibitors Lipid Regulating Agents Therapeutic Uses |
ClinicalTrials.gov processed this record on March 03, 2013