Cellular Immune Responses to Hepatitis B Virus (HBV)- Longitudinal Follow up and Natural History
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It remains unclear why some individuals are able to clear HBV from their bodies while in others HBV is a persistent infection. We plan to investigate this process by collecting blood and analysing how the patient's white blood cells respond to different pieces of the HBV virus. We will use new tools that can precisely tell us which component of the immune response may be different in individuals who are chronically infected with HBV and also in individuals who are also infected with HIV.
The primary aims are therefore:
- To characterize HBV-specific T cell responses in HBV chronic carriers, and identify novel immunogenic regions in both HLA-A2+ and non-HLA-A2+ individuals.
- To determine the effect of HIV infection on HBV-specific T-cell responses
Condition |
---|
Hepatitis B HIV Infections |
Study Type: | Observational |
Study Design: | Observational Model: Cohort Time Perspective: Prospective |
Official Title: | Cellular Immune Responses to Hepatitis B Virus (HBV)- Longitudinal Follow up and Natural History |
![](https://webarchive.library.unt.edu/web/20130302094023im_/http://clinicaltrials.gov/ct2/html/images/frame/triangle.gif)
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
HIV and hepatitis B co-infection
Inclusion Criteria:
There are two groups of patients in this study. Group A mono-infected with Hepatitis B, and those with co-infection HBV/HIV.
Group A inclusion criteria: (also split into 6 recruiting groups)
- Acute hepatitis B
- Chronic hepatitis B, HBV DNA+ve , normal ALT , HBeAg +ve
- Chronic hepatitis B, HBV DNA +ve , normal ALT, HBeAg -ve
- Chronic hepatitis , HBV DNA +ve, increased ALT, no HBV treatment B, HBeAg +ve
- Chronic hepatitis B, HBV DNA +ve , increased ALT, no HBV treatment B, HBeAg -ve
- Chronic hepatitis B, undergoing 'flare' of hepatitis
Group B inclusion criteria:
- To be HIV/HBV co-infected
All patients:
- To be over 18 years
Exclusion Criteria:
- Those who do not fit the inclusion criteria.
![](https://webarchive.library.unt.edu/web/20130302094023im_/http://clinicaltrials.gov/ct2/html/images/frame/triangle.gif)
Australia, Victoria | |
The Alfred Hospital, Commercial Road | |
Melbourne, Victoria, Australia, 3004 |
Principal Investigator: | Sharon Lewin, Professor | Burnet Institute, Melbourne |
![](https://webarchive.library.unt.edu/web/20130302094023im_/http://clinicaltrials.gov/ct2/html/images/frame/triangle.gif)
No publications provided
Responsible Party: | Jennifer Hoy, Professor Jennifer Hoy, The Alfred |
ClinicalTrials.gov Identifier: | NCT00168194 History of Changes |
Other Study ID Numbers: | 235/04 |
Study First Received: | September 9, 2005 |
Last Updated: | January 19, 2012 |
Health Authority: | Australia: National Health and Medical Research Council |
Keywords provided by The Alfred:
HIV |
Additional relevant MeSH terms:
HIV Infections Acquired Immunodeficiency Syndrome Hepatitis Hepatitis A Hepatitis B Lentivirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases |
Immunologic Deficiency Syndromes Immune System Diseases Slow Virus Diseases Liver Diseases Digestive System Diseases Hepatitis, Viral, Human Enterovirus Infections Picornaviridae Infections Hepadnaviridae Infections DNA Virus Infections |
ClinicalTrials.gov processed this record on February 28, 2013