A Study of Retrovir in the Treatment of Psoriasis in HIV-Positive Patients
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
![](https://webarchive.library.unt.edu/web/20130312001138im_/http://clinicaltrials.gov/ct2/html/images/frame/triangle.gif)
To evaluate the feasibility of Retrovir (AZT) in the treatment of psoriasis in HIV antibody positive patients. Retrovir has been shown to be effective in the treatment of AIDS. In addition, the administration of AZT appears to have induced a remission of psoriasis in one case study. In light of AZT's antiviral activity and potential effectiveness as an agent for the treatment of psoriasis, this would be the most likely treatment for HIV positive, psoriatic patients whose disease progresses quickly.
Condition | Intervention |
---|---|
HIV Infections Psoriasis |
Drug: Zidovudine |
Study Type: | Interventional |
Study Design: | Primary Purpose: Treatment |
Official Title: | Retrovir Capsules in the Treatment of Psoriasis in HIV Antibody Positive Patients: A Pilot Study |
![](https://webarchive.library.unt.edu/web/20130312001138im_/http://clinicaltrials.gov/ct2/html/images/frame/triangle.gif)
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria
Study participants must have biopsy-proven psoriasis with 3 distinct psoriatic lesions. (Biopsy-proven Reiter's syndrome patients with 3 distinct cutaneous lesions may be included.) Documented HIV antibody (by federally licensed ELISA test) positive patients.
Prior Medication:
Allowed:
- Zidovudine (AZT).
Exclusion Criteria
Co-existing Condition:
Patients with the following are excluded:
- Presence of any active opportunistic infection.
- Presence of any AIDS-defining neoplasms (excluding Kaposi's sarcoma) such as central nervous system (CNS) lymphoma.
- Known hypersensitivity to zidovudine (AZT).
- Impaired renal function.
- Significant hepatic dysfunction.
Concurrent Medication:
Excluded:
- Topical steroid, anthralin, or tar preparations. Etretinate, methotrexate, or psoralen ultraviolet A (PUVA) therapy. Psoriatic treatment such as systemic agents or topical steroids (emollients used distal to the control lesions and antipruritic shampoos are admissible).
Patients with the following are excluded:
- Presence of any active opportunistic infection.
- Presence of any AIDS-defining neoplasms (excluding Kaposi's sarcoma) such as central nervous system (CNS) lymphoma.
- Known hypersensitivity to zidovudine (AZT).
- Impaired renal function.
- Significant hepatic dysfunction.
Prior Medication:
Excluded:
- Other antiretroviral agents (e.g., suramin, ribavirin, HPA-23, dideoxycytidine).
- Excluded within 2 weeks of study entry:
- Topical steroid, anthralin, or tar preparations.
- Any other experimental therapy drugs which cause significant bone marrow suppression such as antifolates or pyrimethamine.
- Cytolytic chemotherapy.
- Drugs which cause significant nephrotoxicity or hepatotoxicity.
- Rifampin or rifampin derivatives.
- Excluded within 4 weeks of study entry:
- Etretinate, methotrexate, or psoralen ultraviolet A (PUVA) therapy.
- Excluded within 8 weeks of study entry:
- Immunomodulating agents, including steroids, interferon, Isoprinosine, and interleukin 2.
![](https://webarchive.library.unt.edu/web/20130312001138im_/http://clinicaltrials.gov/ct2/html/images/frame/triangle.gif)
![](https://webarchive.library.unt.edu/web/20130312001138im_/http://clinicaltrials.gov/ct2/html/images/frame/triangle.gif)
No publications provided
ClinicalTrials.gov Identifier: | NCT00002286 History of Changes |
Other Study ID Numbers: | 014F, 16 |
Study First Received: | November 2, 1999 |
Last Updated: | June 23, 2005 |
Health Authority: | United States: Food and Drug Administration |
Keywords provided by NIH AIDS Clinical Trials Information Service:
Pilot Projects Psoriasis Acquired Immunodeficiency Syndrome Zidovudine |
Additional relevant MeSH terms:
HIV Infections Acquired Immunodeficiency Syndrome Psoriasis Lentivirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Immunologic Deficiency Syndromes Immune System Diseases Slow Virus Diseases Skin Diseases, Papulosquamous |
Skin Diseases Zidovudine Antimetabolites Molecular Mechanisms of Pharmacological Action Pharmacologic Actions Reverse Transcriptase Inhibitors Nucleic Acid Synthesis Inhibitors Enzyme Inhibitors Anti-Retroviral Agents Antiviral Agents Anti-Infective Agents Therapeutic Uses Anti-HIV Agents |
ClinicalTrials.gov processed this record on March 10, 2013