Genetics of Progressive Multifocal Leukoencephalopathy and Acquired Immunodeficiency Syndrome
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Purpose
This study will identify genetic factors associated with the development of progressive multifocal leukoencephalopathy (PML) in patients with acquired immunodeficiency syndrome (AIDS). PML is a life-threatening infection of the brain that affects about 5 percent of untreated patients with AIDS. Its symptoms include mental deterioration, vision loss, speech disturbances, ataxia (inability to coordinate movements), paralysis, and coma. PML is caused by a polyomavirus called the JC virus.
It is estimated that up to 80 percent of the human population has been exposed to the JC virus, but the disease is very rare. The virus only becomes active in people who have compromised immune systems, such as those undergoing immune suppressive chemotherapy for cancer and those with damaged immune systems due to HIV.
Patients who have participated in the Multicenter AIDS Cohort Study may be eligible for this study, as well as healthy normal volunteers who will serve as controls. The study will review clinical information from patients and analyze genetic factors from both patients and control subjects to investigate genes associated with AIDS and JC virus infection.
| Condition |
|---|
|
PML AIDS |
| Study Type: | Observational |
| Official Title: | Influence of Host Genetic Factors in Development of PML in an AIDS Cohort |
| Estimated Enrollment: | 450 |
| Study Start Date: | August 2005 |
The purpose of this study is to identify host genetic factors that contribute to the development of Progressive Multifocal Leukoencephalopathy (PML) associated with JC virus. JC virus is one of many opportunistic infections that arise in AIDS patients. JC virus is widely distributed in the general population, with estimates of population exposure ranging from 30-80%. JC virus remains latent in the host, and in profoundly immunosuppressed patients, JC virus can cause PML, a fatal disease associated with neurotropic JC virus that lytically infects oligodendrocytes. In untreated AIDS populations, the frequency of PML has been estimated at roughly 5%. This study will identify host genetic factors that may contribute to the development of PML in the AIDS population.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
- No available subjects will be excluded.
Contacts and Locations| United States, California | |
| University of California, Los Angeles | |
| Los Angeles, California, United States, 90095 | |
| United States, Illinois | |
| John H. Stroger, Jr. Hospital of Cook County | |
| Chicago, Illinois, United States, 60612 | |
| Howard Brown Health Center | |
| Chicago, Illinois, United States, 60613 | |
| Northwestern University | |
| Chicago, Illinois, United States, 60611 | |
| United States, Maryland | |
| Johns Hopskins Hospital | |
| Baltimore, Maryland, United States, 21205 | |
| United States, Pennsylvania | |
| University of Pittsburgh | |
| Pittsburgh, Pennsylvania, United States, 15261 | |
More Information
Publications:
| ClinicalTrials.gov Identifier: | NCT00342602 History of Changes |
| Other Study ID Numbers: | 999905218, 05-C-N218 |
| Study First Received: | June 19, 2006 |
| Last Updated: | March 16, 2009 |
| Health Authority: | United States: Federal Government |
Keywords provided by National Institutes of Health Clinical Center (CC):
|
JC Virus Opportunistic Infection Single Nucleotide Polymorphism Genotype Sequencing |
Additional relevant MeSH terms:
|
Acquired Immunodeficiency Syndrome HIV Infections Immunologic Deficiency Syndromes Leukoencephalopathy, Progressive Multifocal Leukoencephalopathies Lentivirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Slow Virus Diseases |
Immune System Diseases Encephalitis, Viral Encephalitis Central Nervous System Viral Diseases Polyomavirus Infections DNA Virus Infections Brain Diseases Central Nervous System Diseases Nervous System Diseases Central Nervous System Infections Demyelinating Diseases |
ClinicalTrials.gov processed this record on March 10, 2013
