A Randomized Comparative Pharmacokinetic Study of Oral Ganciclovir After Treatment With Intravenous Ganciclovir for Cytomegalovirus Gastrointestinal Disease in AIDS Patients
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To determine the oral bioavailability of three dose levels of oral ganciclovir given with and without glutamic acid hydrochloride in patients with cytomegalovirus (CMV) GI disease, and to compare the bioavailability of these regimens to that of standard intravenous (IV) ganciclovir.
Long-term ganciclovir maintenance therapy has been recommended for CMV colitis or esophagitis following induction treatment. Oral ganciclovir is a likely candidate for maintenance because of its possible therapeutic value and ease of administration, but an optimum dose has not been determined. Since oral ganciclovir has a low bioavailability and is more soluble in an acid pH environment, the addition of glutamic acid hydrochloride may enhance gastrointestinal absorption of this drug.
Condition | Intervention | Phase |
---|---|---|
Colitis HIV Infections |
Drug: Glutamic acid hydrochloride Drug: Ganciclovir |
Phase 1 |
Study Type: | Interventional |
Study Design: | Allocation: Randomized Endpoint Classification: Pharmacokinetics Study Primary Purpose: Treatment |
Official Title: | A Randomized Comparative Pharmacokinetic Study of Oral Ganciclovir After Treatment With Intravenous Ganciclovir for Cytomegalovirus Gastrointestinal Disease in AIDS Patients |
Estimated Enrollment: | 24 |
Study Completion Date: | August 1998 |
Long-term ganciclovir maintenance therapy has been recommended for CMV colitis or esophagitis following induction treatment. Oral ganciclovir is a likely candidate for maintenance because of its possible therapeutic value and ease of administration, but an optimum dose has not been determined. Since oral ganciclovir has a low bioavailability and is more soluble in an acid pH environment, the addition of glutamic acid hydrochloride may enhance gastrointestinal absorption of this drug.
All patients receive an induction regimen of IV ganciclovir administered twice daily for 21 to 42 (Per Amendment 3/4/95) days. A permanent venous catheter is implanted for the induction therapy. If clinically improved following induction, patients are then randomized to receive one of three doses of oral ganciclovir, given first without and then with oral glutamic acid hydrochloride, every 8 hours until they reach a steady state. PER AMENDMENT 3/14/95: After subjects have reached steady state with oral ganciclovir and glutamic acid hydrochloride then PK samples will be taken. Subjects will continue the dosing regimen they were assigned to (glutamic acid hydrochloride will be added if it resulted in at least 33% increased bioavailability) for up to 12 months or until relapse of CMV GI disease is documented. Subjects will be followed at monthly intervals for safety evaluation and for evidence of CMV GI relapse. Subjects who have clinical symptoms of relapse will undergo repeat endoscopy or colonoscopy to document the relapse.
![](https://webarchive.library.unt.edu/web/20130309094605im_/http://clinicaltrials.gov/ct2/html/images/frame/triangle.gif)
Ages Eligible for Study: | 13 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria
Concurrent Medication:
Recommended:
- PCP prophylaxis.
Allowed:
- Antiretroviral therapy during induction and pharmacokinetic part of study, provided patient remains on the same antiretroviral therapy for the duration of the study.
- Chemotherapy for Kaposi's sarcoma, provided patient is hematologically stable for at least 30 days prior to study entry.
- Recombinant human erythropoietin.
- GM-CSF and G-CSF.
- Other medications necessary for patient's welfare, at the physician's discretion.
Patients must have:
- HIV infection.
- Biopsy-proven cytomegalovirus (CMV) colitis.
- Life expectancy of at least 3 months.
- No active AIDS-defining opportunistic infection requiring therapy that is known to cause nephrotoxicity or myelosuppression.
NOTE:
- Kaposi's sarcoma is permitted if patients are hematologically stable for at least 30 days prior to study entry.
Exclusion Criteria
Co-existing Condition:
Patients with the following symptoms or conditions are excluded:
- Other etiologies for diarrhea identified at study entry.
PER AMENDMENT 3/14/95:
- For subjects who have diarrhea - no other etiologies for diarrhea identified within 6 weeks of enrollment.
- Known hypersensitivity to study drugs.
- CMV retinitis.
Concurrent Medication:
Excluded:
- Acyclovir or probenecid (PER AMENDMENT 3/14/95).
- Immunomodulators.
- Biologic response modifiers (other than GM-CSF or G-CSF).
- Investigational agents, with the exception of treatment IND drugs.
- Antacids.
- H2 blockers.
- Proton pump inhibitors.
- Foscarnet during induction and pharmacokinetic part of study.
- Intravenous CMV retinitis maintenance therapy (including ganciclovir) during pharmacokinetic part of study.
- Nephrotoxic agents.
Prior Medication:
Excluded within 14 days prior to study entry:
- Immunomodulators.
- Biologic response modifiers (other than GM-CSF or G-CSF).
- Investigational agents, with the exception of treatment IND drugs.
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United States, Alabama | |
Alabama Therapeutics CRS | |
Birmingham, Alabama, United States, 35294 | |
United States, California | |
Ucsf Aids Crs | |
San Francisco, California, United States | |
United States, Missouri | |
Washington U CRS | |
St. Louis, Missouri, United States | |
United States, New York | |
NY Univ. HIV/AIDS CRS | |
New York, New York, United States, 10016 | |
United States, Ohio | |
Univ. of Cincinnati CRS | |
Cincinnati, Ohio, United States, 45267 |
Study Chair: | Jacobson M | |
Study Chair: | Dieterich D | |
Study Chair: | Kotler D | |
Study Chair: | Laine L | |
Study Chair: | Kumar P |
![](https://webarchive.library.unt.edu/web/20130309094605im_/http://clinicaltrials.gov/ct2/html/images/frame/triangle.gif)
Additional Information:
Publications:
Responsible Party: | National Institute of Allergy and Infectious Diseases (NIAID) |
ClinicalTrials.gov Identifier: | NCT00000768 History of Changes |
Other Study ID Numbers: | ACTG 183, 11158 |
Study First Received: | November 2, 1999 |
Last Updated: | March 30, 2012 |
Health Authority: | United States: Federal Government |
Keywords provided by National Institute of Allergy and Infectious Diseases (NIAID):
Intestinal Absorption Ganciclovir Drug Therapy, Combination Cytomegalovirus Infections Colitis |
Administration, Oral Acquired Immunodeficiency Syndrome Biological Availability Glutamic Acid |
Additional relevant MeSH terms:
HIV Infections Acquired Immunodeficiency Syndrome Colitis Gastrointestinal Diseases Digestive System Diseases Lentivirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases |
Immunologic Deficiency Syndromes Immune System Diseases Slow Virus Diseases Gastroenteritis Colonic Diseases Intestinal Diseases Ganciclovir Antiviral Agents Anti-Infective Agents Therapeutic Uses Pharmacologic Actions |
ClinicalTrials.gov processed this record on March 07, 2013