Comparison of Anti HIV Drugs Used Alone or in Combination With Cytosine Arabinoside to Treat Progressive Multifocal Leukoencephalopathy (PML) in HIV-Infected Patients
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To compare the safety and efficacy of antiretroviral therapy (zidovudine plus either didanosine or dideoxycytidine) versus antiretroviral therapy plus intravenous cytarabine (Ara-C) versus antiretroviral therapy plus intrathecal Ara-C in the maintenance or improvement of neurological function over 6 months in HIV-infected individuals who have developed progressive multifocal leukoencephalopathy (PML). To compare the effect of these three treatment regimens on Karnofsky score and MRI studies.
The effectiveness of Ara-C in the treatment of PML, caused by a human DNA papovavirus (designated JC virus) infection, has not been determined, although the most encouraging results have occurred with intrathecal administration of the drug.
Condition | Intervention | Phase |
---|---|---|
HIV Infections Leukoencephalopathy, Progressive Multifocal |
Drug: Filgrastim Drug: Cytarabine Drug: Zidovudine Drug: Zalcitabine Drug: Didanosine |
Phase 2 |
Study Type: | Interventional |
Study Design: | Primary Purpose: Treatment |
Official Title: | A Phase II Multicenter Study Comparing Antiretroviral Therapy Alone to Antiretroviral Therapy Plus Cytosine Arabinoside (Cytarabine; Ara-C) for the Treatment of Progressive Multifocal Leukoencephalopathy (PML) in Human Immunodeficiency Virus (HIV)-Infected Subjects |
Estimated Enrollment: | 90 |
Study Completion Date: | April 1997 |
The effectiveness of Ara-C in the treatment of PML, caused by a human DNA papovavirus (designated JC virus) infection, has not been determined, although the most encouraging results have occurred with intrathecal administration of the drug.
Patients are randomized to receive antiretroviral therapy alone (AZT plus ddI or ddC), antiretroviral therapy plus intravenous Ara-C, or antiretroviral therapy plus intrathecal Ara-C. All patients receive 24 weeks of antiretroviral therapy. Beginning at week 2, patients on the intravenous Ara-C arm receive daily infusions of Ara-C over 5 days, with cycles repeating every 21 days. Patients on the intrathecal Ara-C arm receive single administrations of Ara-C at weeks 2, 3, 4, 5, 6, 8, 10, 12, 16, 20, and 24. A brain biopsy confirmation or in situ hybridization will be required within 7 days after study entry. Patients are followed every 4 weeks.
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria
Concurrent Medication:
Allowed:
- Local intralesional chemotherapy for mucocutaneous Kaposi's sarcoma.
- Topical antifungals, clotrimazole, ketoconazole, fluconazole, and amphotericin B for treatment of mucosal and esophageal candidiasis.
- Foscarnet for newly developed CMV infection, only after discussion with the protocol chair.
- Prophylactic and maintenance therapy for other opportunistic infections, provided patients are considered clinically stable.
- No more than 1000 mg/day acyclovir for herpes simplex.
- Antibiotics for bacterial infections as clinically indicated.
- Antipyretics, analgesics, and antiemetics.
Concurrent Treatment:
Allowed:
- Local radiation therapy for mucocutaneous Kaposi's sarcoma.
Patients must have:
- HIV infection.
- Confirmed PML.
- No other current active opportunistic infections requiring systemic therapy.
- Life expectancy of at least 3 months.
NOTE:
- A durable power of attorney is recommended where severe neurologic or psychiatric impairment can be foreseen while the patient is on study.
Exclusion Criteria
Co-existing Condition:
Patients with the following symptoms or conditions are excluded:
- Current active cryptococcal meningitis, cytomegaloviral encephalitis, toxoplasmosis encephalitis, CNS lymphoma, or neurosyphilis.
NOTE:
- Patients on maintenance therapy for cryptococcal meningitis or toxoplasmosis encephalitis that has been stable for 4 months are permitted.
- Conditions that seriously increase risk of a surgical procedure (e.g., coagulopathy, severe thrombocytopenia).
- Any other disease that would interfere with evaluation of the patient.
- Other life-threatening complications likely to cause death in < 3 months.
Concurrent Medication:
Excluded:
- Ganciclovir.
- Interferon.
- Systemic chemotherapy other than Ara-C (unless specifically allowed).
- Antiretroviral medications other than AZT, ddI, or ddC.
Patients with the following prior conditions are excluded:
History of allergy or intolerance to G-CSF.
Prior Medication:
Excluded:
- Any prior Ara-C.
Excluded within 14 days prior to study:
- Ganciclovir or foscarnet.
- Interferon.
- Antiretroviral medications other than AZT, ddI, or ddC.
- Experimental medications for treatment of PML.
United States, Colorado | |
University of Colorado Hospital CRS | |
Aurora, Colorado, United States, 80262 | |
United States, Florida | |
Univ. of Miami AIDS CRS | |
Miami, Florida, United States, 331361013 | |
United States, Illinois | |
Northwestern University CRS | |
Chicago, Illinois, United States, 60611 | |
United States, Maryland | |
Johns Hopkins Adult AIDS CRS | |
Baltimore, Maryland, United States, 21287 | |
United States, Massachusetts | |
Massachusetts General Hospital ACTG CRS | |
Boston, Massachusetts, United States, 02114 | |
United States, Missouri | |
Washington U CRS | |
St. Louis, Missouri, United States | |
United States, New York | |
Univ. of Rochester ACTG CRS | |
Rochester, New York, United States, 14642 | |
United States, North Carolina | |
Unc Aids Crs | |
Chapel Hill, North Carolina, United States, 275997215 | |
United States, Washington | |
University of Washington AIDS CRS | |
Seattle, Washington, United States, 981224304 |
Study Chair: | Hall C | |
Study Chair: | Timpone J |
Additional Information:
Publications:
Responsible Party: | National Institute of Allergy and Infectious Diseases (NIAID) |
ClinicalTrials.gov Identifier: | NCT00001048 History of Changes |
Other Study ID Numbers: | ACTG 243, 11220 |
Study First Received: | November 2, 1999 |
Last Updated: | April 2, 2012 |
Health Authority: | United States: Federal Government |
Keywords provided by National Institute of Allergy and Infectious Diseases (NIAID):
Leukoencephalopathy, Progressive Multifocal Infusions, Intravenous Cytarabine Zalcitabine Didanosine |
Drug Therapy, Combination Granulocyte Colony-Stimulating Factor Acquired Immunodeficiency Syndrome Zidovudine Injections, Spinal |
Additional relevant MeSH terms:
Acquired Immunodeficiency Syndrome HIV Infections Leukoencephalopathy, Progressive Multifocal Leukoencephalopathies Lentivirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Slow Virus Diseases Immunologic Deficiency Syndromes Immune System Diseases Encephalitis, Viral Encephalitis |
Central Nervous System Viral Diseases Polyomavirus Infections DNA Virus Infections Brain Diseases Central Nervous System Diseases Nervous System Diseases Central Nervous System Infections Demyelinating Diseases Cytarabine Zalcitabine Didanosine Zidovudine Lenograstim Antimetabolites, Antineoplastic Antimetabolites |
ClinicalTrials.gov processed this record on March 07, 2013