Human Atherosclerotic Plaque Inflammation Imaged Using PDG-PET/CT
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People with diabetes are at increased risk for atherosclerosis and have high CVD morbidity and mortality rates. Tools for detecting and quantifying atherosclerotic pro/regression in people with diabetes and other CVD risk factors lack sensitivity and specificity for molecular level events that occur during the early stages of atherogenesis. Inflammatory macrophage infiltration in the vessel endothelium is an early, molecular level proatherogenic event. Activated macrophages consume glucose at a high rate. Novel in vivo radiotracer PET/CT techniques have been developed to detect, image and quantify molecular level events like macrophage inflammation and glucose utilization (18FDG) in human vessels. We propose to develop and test this novel technique in the Center for Clinical Imaging Research (CCIR) at WUMS. We propose that HIV-infected people with significant CVD risk profiles are a suitable, unique human model for testing these novel imaging techniques. HIV-infected people taking anti-HIV medications develop insulin resistance, T2DM, dyslipidemia, central adiposity, and hypertension. HIV replicates in macrophages and represents a chronic proinflammatory condition. Recent data indicate that HIV+ CVD risk have greater risk for atherosclerosis and MI than HIV-negative people. To test feasibility, we hypothesize that: a.18FDG-PET/CT imaging will detect more macrophage glucose uptake and inflammation in the carotid and aorta arteries of HIV-infected people with CVD risk than in HIV-negative controls; b. radiotracer PET/CT measures of proatherogenic processes will correlate with carotid intima media thickness; a standard measure of carotid atherosclerotic burden. We propose to obtain pilot data that shows feasibility for a novel analytical approach that will expand capabilities for researchers interested in studying the links between diabetes, inflammation, and CVD in humans.
Condition |
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Insulin Resistance Atherosclerosis Cardiovascular Disease HIV/AIDS HIV Infections |
Study Type: | Observational |
Study Design: | Observational Model: Cohort Time Perspective: Cross-Sectional |
Official Title: | Human Atherosclerotic Plaque Inflammation Imaged Using PDG-PET/CT |
- Standard uptake values (SUV) for 18Fluoro-deoxyglucose in the carotid vessels and aorta of HIV-infected people with cardiovascular disease risk factors and compared to the same in HIV-seronegative people with no cardiovascular disease risk factors. [ Time Frame: Baseline ] [ Designated as safety issue: No ]
- Carotid intima media thickness measures will be compared to carotid 18FDG SUV. [ Time Frame: Baseline ] [ Designated as safety issue: No ]
Enrollment: | 14 |
Study Start Date: | March 2009 |
Study Completion Date: | March 2010 |
Primary Completion Date: | March 2010 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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HIV-seronegative with no CVD risk factors
Healthy, 35-60 yr old HIV-seronegative men and women with no CVD risk factors (normal fasting glucose tolerance, normal fasting lipid/lipoprotein levels, normotensive, waist circumference <102cm (men) and <88cm (women).
|
HIV+ with CVD risk factors
35-60 yr old HIV-infected men and women with insulin resistance, dyslipidemia, hypertension, and central adiposity.
|
![](https://webarchive.library.unt.edu/web/20130309095156im_/http://clinicaltrials.gov/ct2/html/images/frame/triangle.gif)
Ages Eligible for Study: | 35 Years to 60 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Subjects will be recruited through the AIDS Clinical Trials Unit (ACTU), Washington University Infectious Diseases Clinics, primary care physicians in the community who refer patients to these clinics and Volunteers for Health (VFH).
Inclusion Criteria for HIV+ group:
- confirmed HIV+ status
- 35-60 years old
- stable ART for at least the past 4 mos
- CD4 count >200 cells/µL
- HIV RNA <40copies/mL
- fasting glucose=100-126 mg/dL
- 2hr-oGTT glucose=140-200mg/dL
- fasting triglycerides >150mg/dL
- HDL-cholesterol <40mg/dL (men), <50mg/dL (women)
- resting blood pressure>130/85mmHg
- waist circumference >102cm(men), >88cm(women)
- BMI 25-35 kg/m2
For HIV-negative control group:
- Confirmed HIV negative status
- 35-60 years old
- fasting glucose<100mg/dL,
- 2hr-oGTT glucose<140mg/dL
- fasting triglycerides<150mg/dL
- HDL-cholesterol >40mg/dL (men), >50mg/dL(women)
- normal BP (<130/85mmHg)
- no central adiposity (waist circ.<102cm(men), <88cm(women)
- BMI (25-35 kg/m2)
Exclusion Criteria for both groups:
- history of heart disease, MI, stroke, transient ischemic attack, kidney or liver disease (active hepatitis B or C), dementia
- statins, fibrates, TZDs, antihypertensives, low dose aspirin, or other prescribed/over-the-counter agents with anti-inflammatory properties
- cocaine and methamphetamine users
- serum creatinine >1.5 mg/dL
- pregnant women
- cognitive impairment that limits ability to provide voluntary informed consent
![](https://webarchive.library.unt.edu/web/20130309095156im_/http://clinicaltrials.gov/ct2/html/images/frame/triangle.gif)
United States, Missouri | |
Washington University School of Medicine | |
St.Louis, Missouri, United States, 63110 |
Principal Investigator: | Kevin E Yarasheski, PhD | Washington University School of Medicine |
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Additional Information:
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No publications provided
Responsible Party: | Kevin Yarasheski, Professor of Medicine, Cell Biology & Physiology, Physical Therapy, Washington University School of Medicine |
ClinicalTrials.gov Identifier: | NCT00958815 History of Changes |
Other Study ID Numbers: | 18FDG (completed), DK-020579 |
Study First Received: | August 12, 2009 |
Last Updated: | June 22, 2012 |
Health Authority: | United States: Federal Government |
Keywords provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):
vascular imaging diabetes rupture prone plaques HIV treatment experienced |
Additional relevant MeSH terms:
HIV Infections Acquired Immunodeficiency Syndrome Atherosclerosis Cardiovascular Diseases Inflammation Insulin Resistance Plaque, Atherosclerotic Lentivirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases Sexually Transmitted Diseases, Viral |
Sexually Transmitted Diseases Immunologic Deficiency Syndromes Immune System Diseases Slow Virus Diseases Arteriosclerosis Arterial Occlusive Diseases Vascular Diseases Pathologic Processes Hyperinsulinism Glucose Metabolism Disorders Metabolic Diseases Pathological Conditions, Anatomical |
ClinicalTrials.gov processed this record on March 07, 2013