Effects of Highly Active Anti-Retroviral Therapy on Cardiovascular Health in Infants of HIV-Infected Mothers (CHAART-1)
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This study will determine the impact of highly active antiretroviral therapy (HAART) on the developing cardiovascular system, the evolution of HAART-associated cardiovascular changes over time, and the association between cardiovascular measurements with HAART exposure.
Condition |
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Cardiovascular Diseases Heart Diseases Atherosclerosis HIV Infections Cardiomyopathy, Hypertrophic |
Study Type: | Observational |
Study Design: | Observational Model: Cohort Time Perspective: Prospective |
Official Title: | Cardiac Status of HAART Exposed Infants of HIV-Infected Mothers (CHAART I) |
Blood samples were collected for analysis of cardiac biomarkers high sensitivity C REactive PRotein (hsCRP) and N-terminal Pro-Brain Natriuretic Peptide (NT-proBNP).
Enrollment: | 167 |
Study Start Date: | September 2002 |
Study Completion Date: | December 2006 |
Primary Completion Date: | December 2006 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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1
HIV-uninfected infants born to HIV-infected women with in-utero exposure to HIghly Active Ani-Retroviral Therapy (HAART) who were enrolled in the Women and Infants Transmission Study (WITS).
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2
Historical cohort of HIV-uninfected infants born to HIV-infected women from the Pediatric Pulmonary and Cardiovascular Complications of HIV Study (P2C2 HIV) who were not exposed to HAART.
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Detailed Description:
BACKGROUND:
HIV-infected pregnant women frequently receive HAART, which is associated with reduced maternal-fetal transmission of HIV infection. This has resulted in a rapidly increasing number of seroreverters (HIV-uninfected infants born to HIV-infected women), representing the majority of infants in the United States exposed to HAART. Long-term consequences and toxicities associated with this exposure are not known, but severe cardiotoxicity is suggested in animal models. This study will utilize HIV seroreverter cohorts from the NIH-sponsored Women and Infants Transmission Study (WITS) and Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infections Study (P2C2) to determine how left ventricular (LV) structure and function, serum cardiac troponin T (cTnT), serum pro brain natriuretic peptide (proBNP), and serum high sensitivity C reactive protein (hsCRP) are affected by HAART exposure. In P2C2, patients were recruited from May 1990 to January 1994 from five clinical centers in the United States.
This study was initiated in 2002 in response to a 'Request for Applications' on HAART cardiovascular toxicities.
DESIGN NARRATIVE:
This study will utilize HIV seroreverter cohorts from the NIH-sponsored WITS and P2C2 cohorts to determine how LV structure and function, cTnT, proBNP, and hsCRP are affected by HAART exposure. The p2C2 seroreverter cohort has been exposed to no antiretroviral therapy or zidovudine alone (without HAART) and has persistent significantly depressed LV contractility in comparison to normal with up to 5 years of follow-up. The WITS seroreverter cohort has been exposed mostly to HAART. This cohort will determine the incremental effect of HAART on LV structure and function by following the P2C2 protocol for assessment of LV structure and function. This study will test three hypotheses: 1) that HAART exposure results in fetal and neonatal myocardiocyte injury and death (by serial assessment of cTnT [a biomarker of acute myocardial injury] in both seroreverter cohorts); 2) that HAART exposure results in impaired myocardiocyte mitochondrial function resulting in LV dysfunction (by serial assessment of proBNP [a biomarker related to LV dysfunction], LV volume and pressure increases resulting in LV stretch, and neurohormonal activation); and 3) that HAART exposure results in accelerated atherosclerosis (by serial assessment of hsCRP [a biomarker of generalized inflammation predictive of increased subsequent coronary artery disease]). This study will determine the cardiovascular effects of HAART in seroreverters and the need for future cardiovascular follow-up and cardiovascular preventive and therapeutic trials in this rapidly expanding population.
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Ages Eligible for Study: | up to 2 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
HIV-uninfected infants born to HIV-infected women with in-utero exposure to HIghly Active Ani-Retroviral Therapy (HAART) who were enrolled in the Women and Infants Transmission Study (WITS).
The comparison group will be a historical cohort of HIV-uninfected infants born to HIV-infected women from the Pediatric Pulmonary and Cardiovascular Complications of HIV Study (P2C2 HIV) who were not exposed to HAART.
Inclusion Criteria:
- Children who are actively enrolled in the WITS study, regardless of whether or not they have been exposed to HAART therapy
- Children enrolled into this study from one of the designated WITS clinical sites
- Mothers or legal guardians understand and are willing to provide informed consent with or without the help of an interpreter
Exclusion Criteria:
- Children diagnosed with HIV infection
- Mother has maternal diabetes or phenylketonuria
- Mother has been told by a physician that she has chromosomal defects
- Mother has functional heart defects that have required medications or surgeries
- Mother received cancer chemotherapy or radiation therapy during pregnancy
- Mother used lithium carbonate, anticonvulsants, amphetamines, or angiotensin converting enzyme (ACE) inhibitors during pregnancy
![](https://webarchive.library.unt.edu/web/20130305102342im_/http://clinicaltrials.gov/ct2/html/images/frame/triangle.gif)
United States, Florida | |
University of Miami School of Medicine | |
Miami, Florida, United States, 33101 | |
United States, Illinois | |
University of Illinois - Chicago | |
Chicago, Illinois, United States, 60612 | |
United States, Massachusetts | |
Boston Medical Center | |
Boston, Massachusetts, United States, 02118 | |
United States, New York | |
Columbia University | |
New York, New York, United States, 10027 | |
United States, Texas | |
Baylor College of Medicine | |
Houston, Texas, United States, 77030 |
Principal Investigator: | Steven E. Lipshultz, MD | University of Miami |
![](https://webarchive.library.unt.edu/web/20130305102342im_/http://clinicaltrials.gov/ct2/html/images/frame/triangle.gif)
Publications:
Responsible Party: | Steven E. Lipshultz, MD, University of Miami |
ClinicalTrials.gov Identifier: | NCT00253682 History of Changes |
Other Study ID Numbers: | 342, R01 HL72705 |
Study First Received: | November 10, 2005 |
Last Updated: | February 16, 2009 |
Health Authority: | United States: Federal Government |
Additional relevant MeSH terms:
HIV Infections Acquired Immunodeficiency Syndrome Atherosclerosis Cardiomyopathy, Hypertrophic Cardiovascular Diseases Heart Diseases Hypertrophy Cardiomyopathies Lentivirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases |
Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Immunologic Deficiency Syndromes Immune System Diseases Slow Virus Diseases Arteriosclerosis Arterial Occlusive Diseases Vascular Diseases Aortic Stenosis, Subvalvular Aortic Valve Stenosis Heart Valve Diseases Pathological Conditions, Anatomical |
ClinicalTrials.gov processed this record on March 03, 2013