Rosiglitazone in the Treatment of HIV-Associated Hyperlipidemia
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The purpose of this research is to study the effects of rosiglitazone, a drug usually taken for Type II diabetes, on HIV-associated hyperlipidemia. HIV-associated lipodystrophy is a medical condition characterized by gradual changes in the distribution of body fat. The body fat located in the extremities and face disappears while body fat around the abdomen and upper back increases. Certain biochemical changes occur in association with these changes in fat distribution. Lipid levels particularly serum triglycerides are increased. HDL, the "good cholesterol" is decreased. Higher than normal level of insulin or insulin resistance is also found in this condition. This latter condition is one of the hallmarks of Type II diabetes. The protease inhibitors, a class of HIV medications, are associated with the occurrence of HIV-associated lipodystrophy. It has been suggested that a biochemical pathway known as the peripheral peroxisomal activating receptor (PPAR) gamma system is blocked leading to the onset of this condition.
Rosiglitazone is a new drug approved by the FDA in 1999 for the treatment of type II diabetes. It lowers blood sugar by improving insulin resistance, which as mentioned before, is the hallmark of Type II diabetes. It has also been noted to improve blood lipid levels. Rosiglitazone works by stimulating the PPAR gamma system. It is hoped that this drug can turn on the PPAR system and reverse the HIV-associated lipodystrophy syndrome.
Condition | Intervention | Phase |
---|---|---|
HIV Infections Hyperlipidemia |
Drug: Rosiglitazone |
Phase 2 |
Study Type: | Interventional |
Study Design: | Masking: Open Label Primary Purpose: Treatment |
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Ages Eligible for Study: | 18 Years to 75 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- HIV-positive with CD4 count > 500 and undetectable viral load
- Treated with protease inhibitors for more than three months
- Serum triglycerides > 400mg/dl
- Clinical diagnosis of HIV-associated lipodystrophy
- No history of type II diabetes
- Fasting blood sugar < 126 mg/dl
- No history of liver disease
- Negative Hepatitis B antigen and Hepatitis C antibody
- Not on the following medications: warfarin, digoxin, nifedipine, erythromycin, cyclosporine or HMG coA-reductase inhibitors
- Hemoglobin > 11g/dl
- Women of childbearing age must consent to barrier contraception
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![](https://webarchive.library.unt.edu/web/20130305102433im_/http://clinicaltrials.gov/ct2/html/images/frame/triangle.gif)
No publications provided
ClinicalTrials.gov Identifier: | NCT00006493 History of Changes |
Other Study ID Numbers: | NCRR-M01RR00096-1006, M01RR00096 |
Study First Received: | November 14, 2000 |
Last Updated: | June 23, 2005 |
Health Authority: | United States: Federal Government |
Keywords provided by National Center for Research Resources (NCRR):
HIV-associated hyperlipidemia |
Additional relevant MeSH terms:
HIV Infections Acquired Immunodeficiency Syndrome Hyperlipidemias Lentivirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Immunologic Deficiency Syndromes |
Immune System Diseases Slow Virus Diseases Dyslipidemias Lipid Metabolism Disorders Metabolic Diseases Rosiglitazone Hypoglycemic Agents Physiological Effects of Drugs Pharmacologic Actions |
ClinicalTrials.gov processed this record on March 03, 2013