![[logo] US EPA](https://webarchive.library.unt.edu/web/20121017140546im_/http://www.epa.gov/epafiles/images/logo_epaseal.gif){kind=logo}
Acceptable Substitutes in Industrial Process Refrigeration
Substitutes are reviewed on the basis of ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptable and unacceptable substitutes are updated several times each year. A chronological list of SNAP updates is also available.
Unacceptable substitutesNote: SNAP-related information published in the Federal Register takes precedence over all information on this page.
Acceptable Substitutes for CFCs (class I ODS) in Industrial Process Refrigeration
| Substitute (Name Used in the Federal Register) | Trade Name | Refrigerant Being Replaced | Retrofit/ New |
|---|---|---|---|
| HCFC-22 | 12, 502 | R, N | |
| HCFC-123 | 11 | R, N | |
| HFC-23 | 13, 13B1, 503 | R, N | |
| Ikon A | 12 | R, N | |
| Ikon B | 12 | R, N | |
| THR-02 | 12 | R, N | |
| HFC-134a | 12 | R, N | |
| HFC-227ea | 12 | N | |
| HFC-236fa | 114 | R, N | |
| R-401A, R-401B | MP-39, MP-66 | 12 | R, N |
| R-402A, R-402B | HP-80, HP-81 | 502 | R, N |
| R-403B | ISCEON 69-L | 13, 13B1,
503
Note: R-403B is unacceptable as a substitute for
R-502.
|
R, N |
| R-404A | HP-62 | 502, 12, 500 | R, N |
| R-406A | GHG | 12, 500 | R |
| R-407A, R-407B | Klea 407A, 407B | 502 | R, N |
| R-408A (HCFC Blend Epsilon) | 502 | R | |
| R-411A, R-411B | 12, 500, 502 | R, N | |
| R-507 | AZ-50 | 11, 12, 502 | R, N |
| R-508A (PFC Blend Alpha) | Klea 5R3 | 13, 13B1, 503 | R, N |
| R-508B | Suva 95 | 13, 13B1, 503 | R, N |
| Free Zone (HCFC Blend Delta) | Free Zone / RB-276 | 12 | R, N |
| Freeze 12 | Freeze 12 | 12 | R, N |
| FRIGC FR-12 (HCFC Blend Beta) | FRIGC FR-12 | 12, 500 | R, N |
| GHG-X4 | GHG-X4, Autofrost, Chill-it | 12, 500 | R, N |
| GHG-X5 | GHG-X5 | 12, 500 | R, N |
| GHG-HP (HCFC Blend Lambda) | GHG-HP | 12 | R, N |
| G2018C | G2018C | 12, 500, 502 | R, N |
| Hot Shot | Hot Shot, Kar Kool | 12, 500 | R, N |
| HCFC-22/HCFC-142b | 12 | R, N | |
| NARM-502 | 13, 13B1, 503 | R, N | |
| R-744 (Carbon Dioxide, CO2) | 13, 13B1, 503 | R, N | |
| THR-04 | THR-04 | 502 | R, N |
| FOR12A | FOR12A | 12 | R, N |
| FOR12B | FOR12B | 12 | R, N |
| HFC-134a/HBr (92/8) | 12, 502 | N | |
| Ammonia Vapor Compression | 12, 502 | N | |
| HFE-7100 as a secondary heat transfer fluid in not-in-kind systems | 11, 12, 114, 115, 502 | N | |
| HFE-7200 as a secondary heat transfer fluid in not-in-kind systems | 11, 12, 114, 115, 502 | N | |
| Propane, Propylene, Butane, Hydrocarbon Blend A, Hydrocarbon Blend B) | HC-12a®, OZ-12®, Duracool 12a | CFC-12 | R, N |
| Chlorine | all | R, N | |
| Evaporative/Desiccant Cooling | all | N | |
| Hydrofluoroether-7000 (C3F7OCH3) | HFE-7000 | 11, 113 | R, N |
| RS-24 (2002 formulation) | 12 | R, N | |
| ISCEON 39TC | ISCEON 39TC | 12 | R, N |
| R-407C | Suva 407C, Klea 407C | 502 | R, N |
| R-420A | Choice R-420A | 12, 500 | R, N |
| R-421B | Choice R421B | 12, 502 | R, N |
| R-426A | RS-24 | 12 | R, N |
| R-422C | ICOR XLT1 | 502 | R, N |
| HFC-245fa | Genetron® 245fa | 114 | R, N |
| KDD6 | KDD6 | 12 | R, N |
| Hot Shot 2 R | Hot Shot 2 | 11, 12, 13B1, 113, 114, 500, 502 | R |
Key: R = Retrofit Uses, N = New
Uses
Acceptable Substitutes for HCFCs (class II ODS) in Industrial Process Refrigeration
| Substitute (Name Used in the Federal Register) | Trade Name | Refrigerant Being Replaced | Retrofit/ New |
|---|---|---|---|
| R-410A | AZ-20, Suva 9100, Puron | 22 and blends containing HCFCs | N |
| R-410B | 22, blends containing 22 and/or 142b | N | |
| THR-03 | 22 | N | |
| ISCEON 59, NU-22, R-417A | ISCEON 59, NU-22 | 22, blends containing 22 and/or 142b | R, N |
| R-404A | HP-62 | 22 and blends containing HCFCs | R, N |
| R-407C | Suva 9000, Klea 66 | 22 and blends containing HCFCs | R, N |
| R-507, 507A | AZ-50 | 22 and blends containing HCFCs | R, N |
| R-125/134a/600a (28.1/70.0/1.9) | NU-22 old composition | 22, blends containing 22 and/or 142b | R, N |
| Ammonia Vapor Compression | 22, blends containing 22 and/or 142b | N | |
| HFE-7100 (HFE-449s1) as a secondary heat transfer fluid in not-in-kind systems | 22, blends containing 22 and/or 142b | N | |
| HFE-7200 (HFE-569sf2) as a secondary heat transfer fluid in not-in-kind systems | 22, blends containing 22 and/or 142b | N | |
| Ammonia Absorption | 22, blends containing 22 and/or 142b | N | |
| RS-44 (2003 formulation) | RS-44 | 22, blends containing 22 and/or 142b | R, N |
| ISCEON 79, R-422A | ISCEON 79 | 22 and blends containing HCFCs | R, N |
| R-421A | Choice R421A | 22, blends containing 22 and/or 142b | R, N |
| R-421B | Choice R421B | 22, blends containing 22 and/or 142b | R, N |
| R-422D | ISCEON MO29 | 22, blends containing 22 and/or 142b | R, N |
| R-424A | RS-44 | 22, blends containing 22 and/or 142b | R, N |
| R-426A | RS-24 | 22, blends containing 22 and/or 142b | R, N |
| KDD5, R-438A | ISCEON MO99 | 22, blends containing 22 and/or 142b | R, N |
| R-434A | RS-45 | 22, blends containing 22 and/or 142b | R, N |
| R-428A | RS-52 | 22, blends containing 22 and/or 142b | N |
| R-125/290/134a/600a (55.0/1.0/42.5/1.5) | ICOR AT-22 | 22, blends containing 22 and/or 142b | R, N |
| R-422B | XAC1, NU-22B | 22, blends containing 22 and/or 142b | R, N |
| R-422C | XLT1 | 22, blends containing 22 and/or 142b | R, N |
| Evaporative Cooling | 22, blends containing 22 and/or 142b | N | |
| Desiccant Cooling | 22, blends containing 22 and/or 142b | N | |
| HFE-7000, HFE-347mcc3 | HFE-7000 | 22, blends containing 22 and/or 142b | R, N |
| RS-24 (2002 formulation) | 22, blends containing 22 and/or 142b | R,N | |
| R-744 (Carbon Dioxide, CO2) | 22, blends containing 22 and/or 142b | N | |
| R-423A | ISCEON 39TC | 22, blends containing 22 and/or 142b | R, N |
| HC Blend A | OZ-12 | 22, blends containing 22 and/or 142b | R, N |
| HC Blend B | Original formulation of HC-12a | 22, blends containing 22 and/or 142b | R, N |
| HFC-134a | 22, blends containing 22 and/or 142b | R, N | |
| HFC-227ea | 22, blends containing 22 and/or 142b | N | |
| Nitrogen direct gas expansion | 22, blends containing 22 and/or 142b | N | |
| R-290 (Propane) | 22, blends containing 22 and/or 142b | R, N | |
| R-407A | 22, blends containing 22 and/or 142b | R, N | |
| R-407B | 22, blends containing 22 and/or 142b | R, N | |
| R-600 (Butane) | 22, blends containing 22 and/or 142b | R, N | |
| R-1270 (Propylene) | 22, blends containing 22 and/or 142b | R, N | |
| Stirling cycle | 22, blends containing 22 and/or 142b | N | |
| Hot Shot 2 | Hot Shot 2 | 22, blends containing 22 and/or 142b | R |
| R-407F | Genetron Performax LT | 22, blends containing 22 and/or 142b | R, N |