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Conclusions (1 of 2)

The prevalence of MSK pain varies with age and sex. Most MSK pain in children (97%) results from noninflammatory causes. A review of the patient’s history and performance of an MSK examination remain the most appropriate methods for diagnosing rheumatic etiologies of pediatric MSK pain in a timely fashion. The use of laboratory tests (i.e., ANA, RF, and CCP) as diagnostic measures or for broad screening of pediatric rheumatic conditions remains unsupported.

Abbreviations:
ANA = antinuclear antibody
CCP = cyclic-citrullinated peptide
JIA = juvenile idiopathic arthritis
MSK = musculoskeletal
pSLE = pediatric systemic lupus erythematosus
RF = rheumatoid factor

Presentation: Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Testing for the Evaluation of Musculoskeletal Complaints in Pediatric Populations

Keywords: adolescents | age | children | clinical assessment | juvenile idiopathic arthritis | noninflammatory pain | prevalence | sex | test sensitivity | test specificity | musculoskeletal pain

References:

Wong KO, Bond K, Homik J, et al. Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Tests for Evaluating Musculoskeletal Complaints in Children. Comparative Effectiveness Review No. 50 (Prepared by the University of Alberta Evidence-based Practice Center under Contract No. HHSA 290-2007-10021-I). Rockville, MD: Agency for Healthcare Research and Quality; March 2012. AHRQ Publication No. 12-EHC015-EF. Available at www.effectivehealthcare.ahrq.gov/anatest.cfm.