About Colon CFR
Overview
The Colon CFR includes lifestyle, medical history, and family history data collected from more than 41,000 men and women from 14,500 families with and without colorectal cancer. The Colon CFR began recruiting families in 1997, and all participants are followed up every 5 years to update personal and family histories and expand recruitment if new cases have occurred since baseline.
Male | Female | Unknown | Total | |
---|---|---|---|---|
Population-based families* | 8,951 | |||
Case probandsb | 4,324 | 4,361 | 0 | 8,685 |
Affected relativesb | 634 | 595 | 0 | 1,229 |
Unaffected relativesc | 13,208 | 15,478 | 0 | 28,686 |
Control probandsc | 2,039 | 2,165 | 0 | 4,204 |
Relatives (Australia site only) | 2,130 | 2,126 | 0 | 4,256 |
Total population-based individuals | 22,697 | 25,166 | 0 | 47,863 |
Clinic-based families** | 1,711 | |||
Affected probandsb | 657 | 594 | 1 | 1,252 |
Unaffected probandsc | 111 | 257 | 0 | 368 |
Affected relativesb | 1,068 | 973 | 0 | 2,041 |
Unaffected relativesc | 5,115 | 5,671 | 0 | 10,786 |
Total clinic-based individuals | 6,964 | 7,525 | 1 | 14,490 |
* Includes population-based case proband families from all sites and population-based control proband families from Australia site.
** Includes all clinic-based proband families (counts family ID of affected and unaffected clinic-based probands).
- Enrolled female and male individuals with completed epidemiology questionnaire and/or biospecimen (blood or buccal sample)
- Affected with colorectal cancer at baseline interview or biospecimen collection
- No history of colon cancer at baseline interview or biospecimen collection
Note: Blood and non-blood relatives/individuals excluding the probands.
Biospecimens Collected to Date
Male | Female | Unknown | Total | ||
---|---|---|---|---|---|
Affected Individualsb | Family history/epi dataa,d | 5,535 | 5,621 | 0 | 11,156 |
Proxy family history/epi data | 1,014 | 818 | 0 | 1,832 | |
FFQ datae | 2,556 | 2,872 | 0 | 5,428 | |
Blood/buccal samples | 5,053 | 5,113 | 1 | 10,167 | |
Cell lines | 1,706 | 1,600 | 0 | 3,306 | |
Tumor material | 4,414 | 4,230 | 0 | 8,644 | |
Unaffected Individualsc | Family history/epi dataa,d | 13,265 | 17,264 | 0 | 30,528 |
Proxy family history/epi data | 9,228 | 8,256 | 0 | 17,484 | |
FFQ datae | 6,178 | 8,268 | 0 | 14,446 | |
Blood/buccal samples | 9,196 | 12,462 | 0 | 21,658 | |
Cell lines | 926 | 896 | 0 | 1,822 |
- Baseline data for all population-based and clinic-based individuals, males and females
- Affected with colorectal cancer at baseline interview or biospecimen collection
- No history of colon cancer at baseline interview or biospecimen collection; includes controls from population-based BCFR sites and unaffected clinic-based probands
- Excluding proxy questionnaire completion
- Food Frequency Questionnaire