Perfluorooctanoic acid PFOA
CASRN: 335-67-1
Formula: C8-H-F15-O2
Synonyms/Common Names:
- C8 CARBOXYLIC ACID
- PENTADECAFLUOROOCTANOIC ACID (9CI)
Known Uses:
Dielectric liquid material proposed for use to replace PCBs in transformers
Nomination Background
Short-Term Toxicity
- 28 days (Gavage)
(C91070B)
On Test
- Rats: Harlan Sprague-Dawley
- Dose: Males: 0, 0.625, 1.25, 2.5, 5, or 10 mg/kg; Females: 0, 6.25, 12.5, 25, 50, or 100 mg/kg.
- 4 days (Gavage) Selected (C91070)
- Rats: Harlan Sprague-Dawley
- Dose: Male mice: 1 ml/mg.
Long-Term Carcinogenicity
- 2 years (Dosed-Feed)
(C20614B)
Histopath in progress
- Rats: Harlan Sprague-Dawley
- Dose: MR: 0, 20, 40, 80, 300/0, 300/20, 300/40, or 300/80 ppm.
- 2-YEAR (Dosed-Feed)
(C20614)
Histopath in progress
- Rats: Harlan Sprague-Dawley
- Dose: FR: 0, 300, OR 1000 PPM; MR: 0, 150, OR 300; 60/SEX.
Modified One-Generation
- Dose Range Finding Selected (MOG91070)
- Dose Range finding
- Rats: Harlan Sprague-Dawley; Mice: CD-1 Reg.[Crl:CD1(ICR)]
Special Studies
- Cell Proliferation (Gavage)
(S0174)
Completed
- Citation: CUNNINGHAM, ET.AL., REGULATION OF PERFLUOROOCTANOIC ACID-INDUCED PEROXISOMAL ENZYME ACTIVITIES & HEPATOCELLULAR GROWTH BY ADRENAL HORMONES, HEPATOLOGY 15:316-322,1992.
- Male Rats: Sprague Dawley
- Dose: 150 MG/KG.
Genetic Toxicology
- Micronucleus
(G91070)
Completed
- Rats
- Salmonella
(A98283)
Completed
- Equivocal
Organ Systems Toxicity
- 6 GD to PND 21 Conventional Teratology (Gavage) Selected (R91070)
- Rats: Sprague Dawley
Web page last updated on January 15, 2013