Our Science – LPDS Website

Laboratory of Protein Dynamics and Signaling

Research

The Laboratory of Protein Dynamics and Signaling (LPDS) investigates fundamental cellular processes that are important for cell growth and differentiation, apoptosis, tumorigenesis and metastasis.

A major focus in LPDS is in regulated post-translational modification of proteins, particularly by ubiquitin and sumo. Studies in this area range from structural and biochemical analyses to studies in model systems including Saccharomyces cerevisiae and mice. Additionally, there is a strong interest in the role of Nodal in differentiation and in its signaling through the TGF-beta superfamily. These are detailed in the Research Summaries for individual PIs.

The LPDS is located on the NCI Frederick Campus and has close ties to a number of other Laboratories here, as well as to Laboratories and Branches on the Bethesda Campus. The NCI-Frederick Campus offers state-of-the-art facilities and a highly interactive environment for trainees; it is also home to NCI's advanced technologies and to NCI's program in therapeutic development.

This page was last updated on 8/5/2009.