Dr. John M. Butler

NIST Fellow & Group Leader
Applied Genetics Group
Biomolecular Measurement Division
Material Measurement Laboratory
National Institute of Standards and Technology
100 Bureau Drive, Mail Stop 8314
Gaithersburg, MD 20899-8314, USA

Email: john.butler@nist.gov

Phone: 301-975-4049

Fax: 301-975-8505

EDUCATION

B.S. Chemistry, Brigham Young University, 1992

Ph.D. Chemistry (Analytical), University of Virginia, 1995

Post Doc Biotechnology Division, National Institute of Standards and Technology, 1995-97

SCIENTIFIC AWARDS

National Research Council Postdoctoral Fellowship, NIST 1995-97

British Medical Association Medical Book Competition, Highly Commended, 2001

Presidential Early Career Award for Scientists and Engineers, 2002

U.S. Department of Commerce Silver Medal, 2002

Scientific Prize of the International Society of Forensic Genetics, 2003 [announcement in Analytical Chemistry Feb 2004]

Finalist for the Service to America Medals “Call to Service” Award, 2004 [announcement in GovExec.com]

Honored Alumnus for BYU’s College of Physical and Mathematical Sciences, October 2005

NIST Fellow, March 2008

The Arthur S. Flemming Award (Applied Science, Engineering and Mathematics 2007), June 2008 [announcement]

FBI Laboratory CODIS Award, November 2008

U.S. Department of Commerce Gold Medal, November 2008

Edward Uhler Condon Award, December 2010

Science Watch, #1 world-wide high-impact author in legal medicine and forensic science over the last decade, July 2011 [article] [interview]

JOURNAL EDITORSHIP

Associate Editor of Forensic Science International: Genetics

Editorial Board member of Journal of Forensic Sciences

MEMBERSHIPS and COMMITTEES

International Society of Forensic Genetics (2001-present)
American Society of Human Genetics (2001-2009)
Association of Molecular Pathology (2009)
American Academy of Forensic Sciences (2010-present)

FBI’s Scientific Working Group on DNA Analysis Methods (SWGDAM) (invited guest; 2000-present)
National Institute of Justice World Trade Center Kinship and Data Analysis Panel (WTC KADAP) – lessons learned publication (2002-2003)
Hurricane Katrina Victim Identification DNA Expert Group (2005-2006)
International Committee of the Red Cross (ICRC) DNA Expert Panel (2008)
Department of Defense Quality Assurance Oversight Committee for DNA Analysis (2003-present)
NIJ Expert System TestBed (NEST) Project Team Advisor (2005-present)
NIST Research Library Advisory Board (2007-2010)
ATCC Committee on Authentication of Human Cell Lines: Standardization of STR Profiling (2009-2012)
Virginia Department of Forensic Science Science Advisory Committee (2009-present)

PUBLICATIONS

NISTpub.htm

Textbooks

Butler, J.M. (2001) Forensic DNA Typing: Biology and Technology behind STR Markers. Academic Press, London, 335 pages
Butler, J.M. (2005) Forensic DNA Typing: Biology, Technology, and Genetics of STR Markers (2^nd Edition). Elsevier Academic Press, New York, 688 pages (review)
Butler, J.M. (2010) Fundamentals of Forensic DNA Typing. Elsevier Academic Press, San Diego, 520 pages
Butler, J.M. (2012) Advanced Topics in Forensic DNA Typing: Methodology. Elsevier Academic Press, San Diego, 704 pages
Butler, J.M. (2013) Advanced Topics in Forensic DNA Typing: Interpretation. (in progress)

Ph.D. dissertation

“Sizing and quantitation of polymerase chain reaction products by capillary electrophoresis for use in DNA typing”, University of Virginia, August 1995, 254 pages

Patents

Butler, J.M., Li, J., Monforte, J.A., Becker, C.H. DNA typing by mass spectrometry with polymorphic DNA repeat markers. US Patent 6,090,558 (Awarded July 18, 2000), US Patent 6,764,822 (Awarded July 20, 2004)

Articles Published in Peer-Reviewed Journals and Invited Book Chapters

1. Butler, J.M., McCord, B.R., Jung, J.M., Wilson, M.R., Budowle, B., Allen, R.O. (1994) Quantitation of PCR products by capillary electrophoresis using laser fluorescence. J. Chromatogr. B 658: 271-280.

2. Northrup, D.M., McCord, B.R., Butler, J.M. (1994) Forensic applications of capillary electrophoresis. J. Capillary Electrophoresis 1: 158-168.

3. Butler, J.M., McCord, B.R., Jung, J.M., Allen, R.O. (1994) Rapid separation of the short tandem repeat HUMTH01 by capillary electrophoresis. BioTechniques 17: 1062-1070.

4. Wilson, M.R., Polanskey, D., Butler, J., DiZinno, J.A., Replogle, J., Budowle, B. (1995) Extraction, amplification, and sequencing mitochondrial DNA from human hair shafts. BioTechniques 18: 662-669.

5. Butler, J.M., McCord, B.R., Jung, J.M., Lee, J.A., Budowle, B., Allen, R.O. (1995) Application of dual internal standards for precise sizing of polymerase chain reaction products using capillary electrophoresis. Electrophoresis 16: 974-980.

6. McCord, B.R., Isenberg, A.R., Butler, J.M., Allen, R.O. (1996) Rapid and automated genetic typing using capillary electrophoresis for the analysis of STRs and D1S80. Proceedings of the Sixth International Symposium on Human Identification, Promega Corporation, 1995, pp. 81-87. http://www.promega.com/geneticidproc/ussymp6proc/mccord.htm

7. Butler, J.M., Jiang-Baucom, P., Huang, M., Belgrader, P., Girard, J. (1996) Peptide nucleic acid characterization by MALDI-TOF mass spectrometry. Anal. Chem. 68: 3283-3287.

8. Jiang-Baucom, P., Butler, J.M., Belgrader, P., Girard, J. (1997) DNA typing of sequence polymorphisms by peptide nucleic acids probes and MALDI-TOF mass spectrometry. Anal. Chem. 69: 4894-4898.

9. Butler, J.M. (1997) Effects of sample matrix and injection on DNA separations. Analysis of Nucleic Acids by Capillary Electrophoresis (Heller, C., ed.), Vieweg: Germany, Chapter 5, pp. 125-134.

10. Butler, J.M. (1997) Separation of DNA restriction fragments and PCR products. Analysis of Nucleic Acids by Capillary Electrophoresis (Heller, C., ed.), Vieweg: Germany, Chapter 8, pp. 195-217.

11. Butler, J.M. and Reeder, D.J. (1997) STRBase: a short tandem repeat DNA database for the DNA typing community. Profiles in DNA, Promega Corporation, Volume 1, No. 2, p. 10. http://www.promega.com/profiles/102/ProfilesinDNA_102_10.pdf

12. Butler, J.M., Wilson, M.R., Reeder, D.J. (1998) Rapid mitochondrial DNA typing using restriction enzyme digestion of PCR amplicons followed by capillary electrophoresis separation with laser-induced fluorescence detection. Electrophoresis 19: 119-124.

13. Butler, J.M. and Levin, B.C. (1998) Forensic applications of mitochondrial DNA. Trends in Biotechnology 16: 158-162.

14. Butler, J.M., Ruitberg, C.M., Reeder, D.J. STRBase: a short tandem repeat DNA internet-accessible database. Proceedings of the Eighth International Symposium on Human Identification 1997, Promega Corporation, pp. 38-47. http://www.promega.com/geneticidproc/ussymp8proc/13.html

15. Butler, J.M., Li, J., Monforte, J.A., Becker, C.H., Lee, S. (1998) Rapid and automated analysis of short tandem repeat loci using time-of-flight mass spectrometry. Proceedings of the Eighth International Symposium on Human Identification 1997, Promega Corporation, pp. 94-101. http://www.promega.com/geneticidproc/ussymp8proc/28.html

16. Butler, J.M., Li, J., Shaler, T.A., Monforte, J.A., Becker, C.H. (1998) Reliable genotyping of short tandem repeat loci without an allelic ladder using time-of-flight mass spectrometry. Int. J. Legal Med. 112: 45-49.

17. Butler, J.M. (1998) Rapid assessment of PCR product quality and quantity by capillary electrophoresis. Methods in Molecular Biology Volume 98: Forensic DNA Profiling Protocols (Lincoln, P.J. and Thomson, J., eds.), Humana Press: Totowa, New Jersey, Chapter 6, pp. 39-47.

18. Butler, J.M. (1998) The use of capillary electrophoresis in genotyping STR loci. Methods in Molecular Biology Volume 98: Forensic DNA Profiling Protocols (Lincoln, P.J. and Thomson, J., eds.), Humana Press: Totowa, New Jersey, Chapter 24, pp. 279-289.

19. Li, J., Butler, J.M., Tan, Y., Lin, H., Royer, S., Ohler, L., Shaler, T.A., Hunter, J.M., Pollart, D.J., Monforte, J.A., Becker, C.H. (1999) Single nucleotide polymorphism determination using primer extension and time-of-flight mass spectrometry. Electrophoresis 20:1258-1265.

20. Butler, J.M., Stephens, K.M., Monforte, J.A., Becker, C.H. (1999) High-throughput STR analysis by time-of-flight mass spectrometry. Proceedings of the Second European Symposium on Human Identification 1998, Promega Corporation, pp. 121-130. http://www.promega.com/geneticidproc/eusymp2proc/25.pdf

21. Butler, J.M. and Reeder, D.J. (1999) Capillary electrophoretic separation of DNA fragments. Nucleic Acid Electrophoresis (Tietz, D., ed.), Springer-Verlag: Berlin, Germany, Chapter 7, pp. 170-192.

22. Butler, J.M. (1999) STR analysis by time-of-flight mass spectrometry. Profiles in DNA. Promega Corporation, Volume 2, No. 3, pp. 3-6. http://www.promega.com/profiles/203/ProfilesinDNA_203_03.pdf

23. Butler, J.M. and Becker, C.H. (1999) High-throughput analysis of forensic STR and SNP markers using time-of-flight mass spectrometry. Proceedings of the Ninth International Symposium on Human Identification 1998, Promega Corporation, pp.43-51. http://www.promega.com/geneticidproc/ussymp9proc/content/10.pdf

24. Schwarz, F.P., Robinson, S., Butler, J.M. (1999) Thermodynamic comparison of PNA/DNA and DNA/DNA hybridization reactions at ambient temperature. Nucleic Acids Res. 27: 4792-4800.

25. Butler, J.M. (2000) MALDI-TOF mass spectrometry. Progress in Forensic Genetics 8 (Sensabaugh, G.F., Lincoln, P.J., and Olaisen, B., eds.), Elsevier Science: Amsterdam, The Netherlands, pp. 15-18.

26. Ruitberg, C.M., Reeder, D.J., Butler, J.M. (2001) STRBase: a short tandem repeat DNA database for the human identity testing community. Nucleic Acids Res. 29: 320-322.

27. McCord, B.R. and Butler, J.M. (2001) The application of capillary electrophoresis to the analysis of PCR products used in DNA typing. Methods in Molecular Biology: Clinical and Forensic Applications of Capillary Electrophoresis (Petersen, J. and Mohammad, A.A., eds.), Humana Press: Totowa, New Jersey, pp. 261-284.

28. Butler, J.M. and Reeder, D.J. (2001) Detection of DNA polymorphisms using PCR-RFLP and capillary electrophoresis. Methods in Molecular Biology: Capillary Electrophoresis of Nucleic Acids (Mitchelson, K.R. and Cheng, J., eds.), Humana Press: Totowa, New Jersey, Vol. 2, pp. 49-56.

29. Butler, J.M., Devaney, J.M., Marino, M.A., Vallone, P.M. (2001) Quality control of PCR primers used in multiplex STR amplifications. Forensic Sci. Int., 119: 87-96.

30. Butler, J.M., C.M. Ruitberg, Vallone, P.M. (2001) Capillary electrophoresis as a tool for optimization of multiplex PCR reactions. Fresenius J. Anal. Chem. 369: 200-205.

31. Devaney, J.M. Pettit, E.L., Kaler, S.G., Vallone, P.M., Butler, J.M., Marino, M.A. (2001) Genotyping of two mutations in the HFE gene using single-base extension and high-performance liquid chromatography. Anal. Chem. 73: 620-624.

32. Butler, J.M. and Becker, C.H. (2001) Improved analysis of DNA short tandem repeats with time-of-flight mass spectrometry. Final Report for NIJ Grant 97-LB-VX-0003, Office of Justice Programs, National Institute of Justice (75 published pages); http://www.ojp.usdoj.gov/nij/pubs-sum/188292.htm

33. Schoske, R., Butler, J.M., Vallone, P.M., Kline, M.C., Prinz, M., Redd, A.J., Hammer, M.F. (2001) Development of Y STR megaplex assays. Proceedings of the Twelve International Symposium on Human Identification 2001, Promega Corporation. http://www.promega.com/geneticidproc/ussymp12proc/contents/butler.PDF

34. Kline, M.C., Duewer, D.L., Redman, J.W., Butler, J.M., Boyer, D.A. (2002) Polymerse chain reaction amplification of DNA from aged blood stains: quantitative evaluation of the “suitability for purpose” of four filter papers as archival media. Anal. Chem. 74: 1863-1869.

35. Vallone, P.M., Devaney, J.M., Marino, M.A., Butler, J.M. (2002) A strategy for examining complex mixtures of deoxyoligonucleotides using IP-RP HPLC, MALDI-TOF MS, and informatics. Anal. Biochem. 304: 257-265.

36. Butler, J.M., Schoske, R., Vallone, P.M., Kline, M.C., Redd, A.J., Hammer, M.F. (2002) A novel multiplex for simultaneous amplification of 20 Y chromosome STR markers. Forensic Sci. Int. 129: 10-24.

37. Butler, J.M., David, V.A., O’Brien, S.J., Menotti-Raymond, M. (2002) The MeowPlex: a new DNA test using tetranucleotide STR markers for the domestic cat. Profiles in DNA. Promega Corporation, Volume 5, No. 2, pp. 7–10. http://www.promega.com/profiles/502/ProfilesInDNA_502_07.pdf

38. Redd, A.J., Agellon, A.B., Kearney, V.A., Karafet, T., de Knijff, P., Park, H., Butler, J.M., Hammer, M.F. (2002) Forensic value of fourteen novel STRs on the human Y chromosome. Forensic Sci. Int. 130: 97-111.

39. Schoske, R., Vallone, P.M., Ruitberg, C.M., Butler, J.M. (2003) Multiplex PCR design strategy used for the simultaneous amplification of 10 Y chromosome short tandem repeat (STR) loci. Anal. Bioanal. Chem. 375: 333-343.

40. Butler, J.M., Schoske, R., Vallone, P.M. Highly multiplexed assays for measuring polymorphisms on the Y-chromosome. (2003) Progress in Forensic Genetics 9 (Brinkmann, B. and Carracedo, A., eds.), Elsevier Science: Amsterdam, The Netherlands, International Congress Series 1239, pp. 301-305.

41. Butler, J.M., Schoske, R., Vallone, P.M., Redman, J.W., Kline, M.C. (2003) Allele frequencies for 15 autosomal STR loci on U.S. Caucasian, African American, and Hispanic populations. J. Forensic Sci. 48(4):908-911.

42. Kline, M.C., Duewer, D.L., Redman, J.W., Butler, J.M. (2003) NIST Mixed Stain Study 3: DNA quantitation accuracy and its influence on short tandem repeat multiplex signal intensity. Anal. Chem. 75: 2463-2469.

43. Butler, J.M. (2003) Recent developments in Y-short tandem repeat and Y-single nucleotide polymorphism analysis. Forensic Sci. Rev. 15:91-111.

44. Butler, J.M., Shen, Y., McCord, B.R. (2003) The development of reduced size STR amplicons as tools for analysis of degraded DNA. J. Forensic Sci. 48(5): 1054-1064.

45. Schoske, R., Vallone, P.M., Kline, M.C., Redman, J.W., Butler, J.M. (2004) High-throughput Y-STR typing of U.S. populations with 27 regions of the Y chromosome using two multiplex PCR assays, Forensic Sci. Int. 139: 107-121.

46. Butler, J.M. and Vallone, P.M. (2004) High-throughput genetic analysis through multiplexed PCR and multi-capillary electrophoresis. PCR Technologies: Current Innovations (2^nd edition), Weissensteiner, T., Griffin, H.G., Griffin, A. (Eds.), CRC Press: Boca Raton, Chapter 11, pp 111-120.

47. Vallone, P.M. and Butler, J.M. (2004) Y-SNP typing of U.S. African American and Caucasian samples using allele-specific hybridization and primer extension. J. Forensic Sci. 49(4): 723-732.

48. Vallone, P.M. and Butler, J.M. (2004) Multiplexed assays for evaluation of Y-SNP markers in U.S. populations. Progress in Forensic Genetics 10, Elsevier Science: Amsterdam, The Netherlands, International Congress Series 1261, 85-87.

49. Butler, J.M. and Schoske, R. (2004) Forensic value of the multi-copy Y-STR marker DYS464. Progress in Forensic Genetics 10, Elsevier Science: Amsterdam, The Netherlands, International Congress Series 1261, 278-280.

50. Chung, D.T., Drabek, J., Opel, K.L., Butler, J.M., McCord, B.R. (2004) A study on the effects of degradation and template concentration on the efficiency of the STR miniplex primer sets. J. Forensic Sci. 49(4): 733-740.

51. Butler, J.M. (2004) Short tandem repeat analysis for human identity testing. Current Protocols in Human Genetics, John Wiley & Sons, Hoboken, NJ, Unit 14.8, (Supplement 41), pp. 14.8.1-14.8.22

52. Vallone, P.M., Hamm, R.S., Coble, M.D., Butler, J.M., Parsons, T.J. (2004) A multiplex allele-specific primer extension assay for 11 forensically informative SNPs distributed throughout the mitochondrial genome. Int. J. Legal Med. 118: 147-157.

53. Drabek, J., Chung, D.T., Butler, J.M., McCord, B.R. (2004) Concordance study between miniplex STR assays and a commercial STR typing kit. J. Forensic Sci. 49(4): 859-860.

54. Butler, J.M. and Schoske, R. (2004) Duplication of DYS19 flanking regions in other parts of the Y-chromosome. Int. J. Legal Med. 118: 178-183.

55. Butler, J.M., Buel, E., Crivellente, F., McCord, B.R. (2004) Forensic DNA typing by capillary electrophoresis: using the ABI Prism 310 and 3100 Genetic Analyzers for STR analysis. Electrophoresis 25: 1397-1412.

56. Vallone, P.M. and Butler, J.M. (2004) AutoDimer: a screening tool for primer-dimer and hairpin structures. Biotechniques 37(2):226-231.

57. Duewer, D.L., Kline, M.C., Redman, J.W., Butler, J.M. (2004) NIST Mixed Stain Study #3: signal intensity balance in commercial short tandem repeat multiplexes. Anal. Chem. 76: 6928-6934.

58. Just, R.S., Irwin, J.A., O'Callaghan, J.E., Saunier, J.L., Coble, M.D., Vallone, P.M., Butler, J.M., Barritt, S.M., Parsons, T.J. (2004) Toward increased utility of mtDNA in forensic identifications. Forensic Sci. Int. 146S: S147-S149.

59. Coble, M.D. and Butler, J.M. (2005) Characterization of new miniSTR loci to aid analysis of degraded DNA. J. Forensic Sci. 50(1): 43-53.

60. Butler, J.M. and Butler, T.W. (2005) DNA for detectives. Rape Investigation Handbook (Savino, J.O. and Turvey, B.E., eds.), Elsevier Academic Press: New York, pp. 165-174.

61. Butler, J.M. (2005) Constructing STR multiplex assays. Methods in Molecular Biology: Forensic DNA Typing Protocols (Carracedo, A., ed.), Humana Press: Totowa, New Jersey, 297: 53-66.

62. Kline, M.C., Vallone, P.M., Redman, J.W., Duewer, D.L., Calloway, C.D., Butler, J.M. (2005) Mitochondrial DNA typing screens with control region and coding region SNPs. J. Forensic Sci. 50(2): 377-385.

63. Vallone, P.M., Decker, A.E., Butler, J.M. (2005) Allele frequencies for 70 autosomal SNP loci with U.S. Caucasian, African American, and Hispanic samples. Forensic Sci. Int. 149: 279-286.

64. Kline, M.C., Duewer, D.L., Redman, J.W., Butler, J.M. (2005) Results from the NIST 2004 DNA Quantitation Study. J. Forensic Sci. 50(3):571-578.

65. Butler, J.M., Decker, A.E., Kline, M.C., Vallone, P.M. (2005) Chromosomal duplications along the Y-chromosome and their potential impact on Y-STR interpretation. J. Forensic Sci. 50(4): 853-859.

66. Butler, J.M. and Schoske, R. (2005) U.S. population data for the multi-copy Y-STR locus DYS464. J. Forensic Sci, 50(4): 975-977.

67. Butler, J.M., Appleby, J.E., Liu, D., Duewer, D.L. (2005) Locus-specific brackets for reliable typing of Y-chromosome short tandem repeat markers. Electrophoresis 26: 2583-2590.

68. Brettell, T.A., Butler, J.M., Saferstein, R. (2005) Forensic science. Anal. Chem. 77: 3839-3860.

69. Menotti-Raymond, M.A., David, V.A., Wachter, L.A., Butler, J.M., O’Brien, S.J. (2005) An STR forensic typing system for genetic individualization of domestic cat (Felis catus) samples, J. Forensic Sci. 50(5):1061-1070.

70. Biesecker, L.G., Bailey-Wilson, J.E., Ballantyne, J., Baum, H., Bieber, F.R., Brenner, C., Budowle, B., Butler, J.M., Carmody, G., Conneally, P.M., Duceman, B., Eisenberg, A., Forman, L., Kidd, K.K., LeClair, B., Niezgoda, S., Parsons, T., Pugh, E., Shaler, R., Sherry, S.T., Sozer, A., Walsh, A. (2005) DNA identifications after the 9/11 World Trade Center attack. Science 310:1122-1123.

71. Kline, M.C., Vallone, P.M., Decker, A.E., Redman, J.W., Duewer, D.L., Butler, J.M. (2005) Testing candidate DNA quantitation standards with several real-time quantitative PCR methods. Proceedings of the 16^th International Symposium on Human Identification. http://www.promega.com/geneticidproc/ussymp16proc/abstracts/kline.pdf.

72. Butler, J.M. (2006) High-throughput genotyping of short tandem repeat DNA markers. The Encyclopedia of Mass Spectrometry: Volume 3, Biological Applications, Part B: Carbohydrates, Nucleic Acids and other Biological Compounds (Caprioli, R.M., ed.), Elsevier: New York, pp. 85-102.

73. Vallone, P.M. and Butler, J.M. (2006) Analysis of DNA single nucleotide polymorphisms. The Encyclopedia of Mass Spectrometry: Volume 3, Biological Applications, Part B: Carbohydrates, Nucleic Acids and other Biological Compounds (Caprioli, R.M., ed.), Elsevier: New York, pp. 39-51.

74. Butler, J.M., Decker, A.E., Vallone, P.M., Kline, M.C. (2006) Allele frequencies for 27 Y-STR loci with U.S. Caucasian, African American, and Hispanic samples. Forensic Sci. Int. 156: 250-260.

75. Gusmão, L., Butler, J.M., Carracedo, A., Gill, P., Kayser, M., Mayr, W.R., Morling, N., Prinz, M., Roewer, L., Tyler-Smith, C., Schneider, P.M. (2006) DNA Commission of the International Society of Forensic Genetics (ISFG): An update of the recommendations on the use of Y-STRs in forensic analysis. Forensic Sci. Int. 157: 187-197.

76. Gusmão, L., Butler, J.M., Carracedo, A., Gill, P., Kayser, M., Mayr, W.R., Morling, N., Prinz, M., Roewer, L., Tyler-Smith, C., Schneider, P.M. (2006) DNA Commission of the International Society of Forensic Genetics (ISFG): An update of the recommendations on the use of Y-STRs in forensic analysis. Int. J. Legal Med. 120: 191-200.

77. Dixon, L.A., Dobbins, A.E., Pulker, H., Butler, J.M., Vallone, P.M., Coble, M.D., Parson, W., Berger, B., Grubweiser, P., Mogensen, H.S., Morling, N., Nielsen, K., Sanchez, J.J., Petkovski, E., Carracedo, A., Sanchez-Diz, P., Brion, M., Irwin, J.A., Just, R.S., Loreille, O., Parsons, T.J., Syndercombe-Court, D., Schmitter, H., Gill, P. (2006) Analysis of artificially degraded DNA using STRs and SNPs--results of a collaborative European (EDNAP) exercise. Forensic Sci. Int. 164: 33-44.

78. Butler, J.M. (2006) Genetics and genomics of core STR loci used in human identity testing. J. Forensic Sci. 51(2): 253-265.

79. Butler, J.M., Coble, M.D., Decker, A.E., Duewer, D.L., Hill, C.R., Kline, M.C., Redman, J.W., Vallone, P.M. (2006) Setting standards and developing technology to aid the human identity testing community. Progress in Forensic Genetics 11, Elsevier Science: Amsterdam, The Netherlands, International Congress Series 1288, 628-635.

80. Coble, M.D., Hill, C.R., Vallone, P.M., Butler, J.M. (2006) Characterization and performance of new miniSTR loci for typing degraded samples. Progress in Forensic Genetics 11, Elsevier Science: Amsterdam, The Netherlands, International Congress Series 1288, 504-506.

81. Vallone, P.M., Decker, A.E., Coble, M.D., Butler, J.M. (2006) Evaluation of an autosomal SNP 12-plex assay. Progress in Forensic Genetics 11, Elsevier Science: Amsterdam, The Netherlands, International Congress Series 1288, 61-63.

82. Duewer, D.L. and Butler, J.M. (2006) MULTIPLEX_QA: an exploratory quality assessment tool for multiplexed electrophoretic assays. Electrophoresis 27: 3735-3746.

83. Mulero, J.J., Budowle, B., Butler, J.M., Gusmão, L. (2006) Letter to the Editor--Nomenclature and allele repeat structure update for the Y-STR locus GATA H4. J. Forensic Sci. 51(3): 694.

84. Coble, M.D., Kline, M.C., Redman, J.W., Decker, A.E., Vallone, P.M., Butler, J.M. (2006) An investigation of discrimination capacity and the cause of null alleles in Linear Array mitostrips using control region sequence data. submitted.

85. Butler, J.M. (2006) Debunking some urban legends surrounding validation within the forensic DNA community. Profiles in DNA (Promega Corporation), vol. 9(2), pp. 3-6; see also http://www.promega.com/profiles/902/ProfilesInDNA_902_03.pdf.

86. Butler, J.M. (2006) MiniSTRs: past, present, and future. Forensic News (Applied Biosystems), October 2006 [.pdf]

87. Butler, J.M. (2007) Forensic DNA testing. Genetic Variation: A Laboratory Manual (Eds. Gabriel, Stephens, and Weiner), Cold Spring Harbor Laboratory Press. Chapter 34, pp. 437-451.

88. Butler, J.M., Coble, M.D., Vallone, P.M. (2007) STRs vs SNPs: thoughts on the future of forensic DNA testing. Forensic Sci. Med. Pathol. 3: 200-205.

89. Butler, J.M. (2007) Validation: what is it, why does it matter, and how should it be done? Forensic News (Applied Biosystems), January 2007 [.pdf]

90. Butler, J.M. and Coble, M.D. (2007) Authors' Response to Letter to Editor [regarding nomenclature for new miniSTR locus D10S1248]. J. Forensic Sci. 52(2): 494.

91. Barni, F., Salata, E., Rapone, C., Kline, M., Lago, G., Butler, J., Berti, A. (2007) Characterisation of novel alleles and duplication events in the STR DYS19, DYS439, DYS389II and DYS385 loci. Identity (Promega Newsletter for Europe, Middle East and Africa), Spring 2007, pp. 1-3. [.pdf]

92. Decker, A.E., Kline, M.C., Vallone, P.M., Butler, J.M. (2007) The impact of additional Y-STR loci on resolving common haplotypes and closely related individuals. FSI Genetics 1:215-217.

93. Hill, C.R., Kline, M.C., Mulero, J.J., Lagace, R.E., Chang, C.-W., Hennessy, L.K., Butler, J.M. (2007) Concordance study between the AmpFlSTR MiniFiler PCR Amplification Kit and conventional STR typing kits. J. Forensic Sci. 52(4): 870-873.

94. Hill, C.R., Coble, M.D., Butler, J.M. (2008) Characterization of 26 miniSTR loci for improved analysis of degraded DNA samples. J. Forensic Sci. 53(1):73-80.

95. Opel, K.L., Chung, D.T., Drabek, J., Butler, J.M., McCord, B.R. (2007) Developmental validation of reduced-size STR miniplex primer sets. J. Forensic Sci. 52(6): 1263-1271.

96. Decker, A.E., Kline, M.C., Redman, J.W., Reid, T.M., Butler, J.M. (2008) Analysis of mutations in father-son pairs with 17 Y-STR loci. FSI Genetics 2(3):e31-e35.

97. Brettell, T.A., Butler, J.M., Almirall, J.R. (2007) Forensic science. Anal. Chem. 79: 4365-4384.

98. Butler, J.M., Hill, C.R., Decker, A.E., Kline, M.C., Reid, T.M., Vallone, P.M. (2007) New autosomal and Y-chromosome STR loci: characterization and potential uses. Proceedings of the Eighteenth International Symposium on Human Identification. See http://www.promega.com/geneticidproc/

99. Vallone, P.M., Kline, M.C., Duewer, D.L., Decker, A.E., Redman, J.W., Travis, J.C., Smith, M.V., Butler, J.M. (2008) Development and usage of a NIST Standard Reference Materials for real-time PCR quantitation of human DNA. Forensic Science International: Genetics Supplement Series (Progress in Forensic Genetics 12) 1(1): 80-82.

100. Butler, J.M. (2007) Short tandem repeat typing technologies used in human identity testing. BioTechniques 43(4): Sii-Sv.

101. Butler, J.M. (2008) New resources for the forensic genetics community available on the NIST STRBase website. Forensic Science International: Genetics Supplement Series (Progress in Forensic Genetics 12) 1(1): 97-99.

102. Butler, J.M., Hill, C.R., Decker, A.E., Kline, M.C., Vallone, P.M. (2008) New autosomal STR loci. Forensic Science International: Genetics Supplement Series (Progress in Forensic Genetics 12) 1(1): 95-96.

103. Butler, J.M., Budowle, B., Gill, P., Kidd, K.K., Phillips, C., Schneider, P.M., Vallone, P.M., Morling, N. (2008) Report on ISFG SNP panel discussion. Forensic Science International: Genetics Supplement Series (Progress in Forensic Genetics 12) 1(1): 471-472.

104. Sanchez, J.J., Børsting, C., Balogh, K., Berger, B., Bogus, M., Butler, J.M., Carracedo, A., Syndercombe Court, D., Dixon, L.A., Filipović, B., Fondevila, M., Gill, P., Harrison, C.D., Hohoff, C., Huel, R., Ludes, B., Parson, W., Parsons, T.J., Petkovski, E., Phillips, C., Schmitter, H., Schneider, P.M., Vallone, P.M., Morling, N. (2008) Forensic typing of autosomal SNPs with a 29 SNP-multiplex--Results of a collaborative EDNAP exercise. FSI Genetics 2(3): 176-183.

105. Hill, C.R., Butler, J.M., Vallone, P.M. (2009) A 26plex autosomal STR assay to aid human identity testing. J. Forensic Sci. 54(5): 1008-1015. -- see also http://www.cstl.nist.gov/biotech/strbase/str26plex.htm.

106. Vallone, P.M., Hill, C.R., Butler, J.M. (2008) Demonstration of rapid multiplex PCR amplification involving 16 genetic loci. FSI Genetics 3(1): 42-45.

107. Takayama, T., Takada, N., Suzuki, R., Nagaoka, S., Watanabe, Y., Kumagai, R., Aoki, Y., Butler, J.M. (2009) Determination of deleted regions on Yp11.2 of amelogenin negative male. Legal Med. 11: S578-S580.

108. Kline, M.C., Duewer, D.L., Travis, J.C., Smith, M.V., Redman, J.W., Vallone, P.M., Decker, A.E., Butler, J.M. (2009) Production and certification of NIST Standard Reference Material 2372 Human DNA Quantitation Standard. Anal. Bioanal. Chem. 394: 1183-1192.

109. Brettell, T.A., Butler, J.M., Almirall, J.R. (2009) Forensic science. Anal. Chem. 81: 4695-4711.

110. Butler, J.M., Hill, C.R., Kline, M.C., Duewer, D.L., Sprecher, C.J., McLaren, R.S., Rabbach, D.R., Krenke, B.E., Storts, D.R. (2009) The single most polymorphic STR locus: SE33 performance in U.S. populations. Forensic Science International: Genetics Supplement Series (Progress in Forensic Genetics 13) 2: 23-24. [available at http://www.fsigeneticssup.com]

111. Vallone, P.M., Hill, C.R., Lewis, K.E., Diegoli, T.M., Coble, M.D., Butler, J.M. (2009) Uses of the NIST 26plex STR assay for human identity testing. Forensic Science International: Genetics Supplement Series (Progress in Forensic Genetics 13) 2: 29-30. [available at http://www.fsigeneticssup.com]

112. Vallone, P.M., Hill, C.R., Podini, D., Butler, J.M. (2009) Rapid amplification of commercial STR typing kits. Forensic Science International: Genetics Supplement Series (Progress in Forensic Genetics 13) 2: 111-112. [available at http://www.fsigeneticssup.com]

113. Butler, J.M., Schneider, P.M., Carracedo, A. (2010) Editorial: Journal update. Forensic Sci. Int. Genet. 4: 143-144.

114. Carracedo, A., Butler, J.M., Gusmao, L., Parson, W., Roewer, L., Schneider, P.M. (2010) Editorial: Publication of population data for forensic purposes. Forensic Sci. Int. Genet. 4: 145-147.

115. Butler, J.M. and Hill, C.R. (2010) Scientific issues with analysis of low amounts of DNA. Profiles in DNA (Promega), 13(1). Available at http://www.promega.com/profiles/.

116. Hill, C.R., Kline, M.C., Duewer, D.L., Butler, J.M. (2010) Strategies for concordance testing. Profiles in DNA (Promega), 13(1). Available at http://www.promega.com/profiles/.

117. Hill, C.R., Duewer, D.L., Kline, M.C., Sprecher, C.J., McLaren, R.S., Rabbach, D.R., Krenke, B.E., Ensenberger, M.G., Fulmer, P.M., Stort, D.R., Butler, J.M. (2011) Concordance and population studies along with stutter and peak height ratio analysis for the PowerPlex® ESX 17 and ESI 17 Systems. Forensic Sci. Int. Genet. 5(4): 269-275.

118. Masters, J.R.W., Alston-Roberts, C., Barallon, R., Bauer, S.R., Butler, J.M., Capes-Davis, A., Dirks, W.G., Elmore, E., Furtado, M., Kline, M.C., Kerrigan, L., Kohara, A., Los, G.V., MacLeod, R.A.F., Nardone, M., Nardone, R.M., Nims, R.W., Price, P.J., Reid, Y.A., Shewale, J., Sykes, G., Steuer, A.F., Storts, D.R., Thomson, J., Taraporewala, Z. (2010) Cell line misidentification: the beginning of the end. Nature Rev. Cancer 10: 441-448.

119. Barallon, R., Bauer, S.R., Butler, J.M., Capes-Davis, A., Dirks, W.G., Elmore, E., Furtado, M., Kline, M.C., Kohara, A., Los, G.V., MacLeod, R.A.F., Masters, J.R.W., Nardone, M., Nardone, R.M., Nims, R.W., Price, P.J., Reid, Y.A., Shewale, J., Sykes, G., Steuer, A.F., Storts, D.R., Thomson, J., Taraporewala, Z., Alston-Roberts, C., Kerrigan, L. (2010). Recommendation of short tandem repeat profiling for authenticating human cell lines, stem cells, and tissues. In Vitro Cell Dev Biol Anim. 46(9):727-32.

120. Kline, M.C., Hill, C.R., Decker, A.E., Butler, J.M. (2011) STR sequence analysis for characterizing normal, variant, and null alleles. Forensic Sci. Int. Genet. 5(4): 329-332.

121. O’Connor, K.L., Hill, C.R., Vallone, P.M., Butler, J.M. (2011) Linkage disequilibrium analysis of D12S391 and vWA in U.S. population and paternity samples. Forensic Sci. Int. Genet. 5(5): 538-540. [see also O’Connor, K.L., Hill, C.R., Vallone, P.M., Butler, J.M. (2011) Corrigendum to "Linkage disequilibrium analysis of D12S391 and vWA in U.S. population and paternity samples" Forensic Sci. Int. Genet. 5(5): 541-542].

122. O’Connor, K.L., Butts, E., Hill, C.R., Butler, J.M., Vallone, P.M. (2010) Evaluating the effect of additional forensic loci on likelihood ratio values for complex kinship analysis. Proceedings of the Twenty-first International Symposium on Human Identification. See http://www.promega.com/geneticidproc/.

123. Schneider, P.M., Butler, J.M., Carracedo, A. (2011) Publications and letters related to the forensic genetic analysis of low amounts of DNA. Forensic Sci. Int. Genet. 5: 1-2.

124. Brettell, T.A., Butler, J.M., Almirall, J.R. (2011) Forensic science. Anal. Chem. 83: 4539-4556.

125. Coble, M.D., Kline, M.C., Butler, J.M. (2011) Metrology needs and NIST resources for the forensic DNA community. Accred. Qual. Assur. 16: 293-297.

126. Phillips, C., Fondevila, M., Vallone, P.M., Carla, S., Freire-Aradas, A., Butler, J.M., Lareu, M.V., Carracedo, A. (2011) Characterization of U.S. population samples using a 34plex ancestry informative SNP multiplex. Forensic Sci. Int. Genet.: Suppl. Ser. 3: e182-e183. [available at http://www.fsigeneticssup.com]

127. Butts, E.L.R., Kline, M.C., Duewer, D.L., Hill, C.R., Butler, J.M., Vallone, P.M. (2011) NIST validation studies on the 3500 Genetic Analyzer. Forensic Sci. Int. Genet.: Suppl. Ser. 3: e184-e185. [available at http://www.fsigeneticssup.com]

128. Hill, C.R., Kline, M.C., Duewer, D.L., Butler, J.M. (2011) Concordance testing comparing STR multiplex kits with a standard data set. Forensic Sci. Int. Genet.: Suppl. Ser. 3: e188-e189. [available at http://www.fsigeneticssup.com]

129. Kline, M.C., Butts, E.L.R., Hill, C.R., Coble, M.D., Duewer, D.L., Butler, J.M. (2011) The new Standard Reference Material 2391c: PCR-based DNA profiling standard. Forensic Sci. Int. Genet.: Suppl. Ser. 3: e355-e356. [available at http://www.fsigeneticssup.com]

130. Fondevila, M., Pereira, R., Gusmao, L., Phillips, C., Lareu, M.V., Carracedo, A., Butler, J.M., Vallone, P.M. (2011) Forensic performance of insertion-deletion marker systems. Forensic Sci. Int. Genet.: Suppl. Ser. 3: e443-e444. [available at http://www.fsigeneticssup.com]

131. Diegoli, T.M., Linacre, A., Vallone, P.M., Butler, J.M., Coble, M.D. (2011) Allele frequency distribution of twelve X-chromosomal short tandem repeat markers in four U.S. population groups. Forensic Sci. Int. Genet.: Suppl. Ser. 3: e481-e483. [available at http://www.fsigeneticssup.com]

132. Butler, J.M., Hill, C.R., Kline, M.C., Bastisch, I., Weirich, V., McLaren, R.S., Storts, D.R. (2011) SE33 variant alleles: sequences and implications. Forensic Sci. Int. Genet.: Suppl. Ser. 3: e502-e503. [available at http://www.fsigeneticssup.com]

133. Fondevila, M., Santos, C., Phillips, C., Carracedo, A., Butler, J.M., Lareu, M.V., Vallone, P.M. (2011) An assessment of linkage between forensic markers: core STRs, mini-STRs and InDels. Proceedings of the 22nd International Symposium on Human Identification. Available at http://www.promega.com/products/pm/genetic-identity/ishi-conference-proceedings/22nd-ishi-oral-presentations/.

134. Butler, J.M. and Hill, C.R. (2012) Biology and genetics of new autosomal STR loci useful for forensic DNA analysis. Forensic Sci. Rev. 24(1): 15-26.

135. McLaren, R.S., Patel, J., Storts, D.R., Hill, C.R., Kline, M.C., Butler, J.M. (2012) Improved primer pair for the SE33 locus in the PowerPlex ESI 17 Pro System. Profiles in DNA. Available at http://www.promega.com/resources/articles/profiles-in-dna/2012/improved-primer-pair-for-the-se33-locus-in-the-powerplex-esi-17-pro-system/.

136. Fondevila, M., Phillips, C., Santos, C., Pereira, R., Gusmao, L., Carracedo, A., Butler, J.M., Lareu, M.V., Vallone, P.M. (2012) Forensic performance of two insertion-deletion marker assays. Int. J. Legal Med. 126: 725-737.

137. Fondevila, M., Phillips, C., Santos, C., Freire Aradas, A., Vallone, P.M., Butler, J.M., Lareu, M.V., Carracedo, A. (2012) Revision of the SNPforID 34-plex forensic ancestry test: assay enhancements, standard reference sample genotypes and extended population studies. Forensic Sci. Int. Genet. (in press).

PRESENTATIONS

For list of recent presentations (over 250 invited talks and training workshops given since 2000), see http://www.cstl.nist.gov/biotech/strbase/NISTpub.htm and http://www.cstl.nist.gov/biotech/strbase/training.htm.

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Last Updated: 10/12/2012