Rules Devised for Building Proteins Not Found in Nature |
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November 29, 2012 • University of Washington |
DNA Methylation Profiles Offer New Measure of “Biological” Age |
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November 21, 2012 • University of California, San Diego |
Flu Antibody's 'One-Handed Grab' May Boost Universal Vaccine Effort |
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September 16, 2012 • The Scripps Research Institute |
Three Human Antibodies Provide Broad Protection Against Flu |
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August 9, 2012 • The Scripps Research Institute |
Structural Studies Illuminate Large, Medically Important Protein Class |
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July 12, 2012 • The Scripps Research Institute |
Researchers Reveal the Structure of a Key Protein Involved in RNA Silencing |
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April 26, 2012 • The Scripps Research Institute |
Atomic Structure of Molecule That Binds to Opioids in the Human Brain Opens the Door to Developing Better Drugs for Pain, Depression and Other Conditions |
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March 21, 2012 • The Scripps Research Institute |
PSI’s Clearinghouse for DNA Gets a Boost |
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October 20, 2011 • Arizona State University |
Structure Sheds Light on Why Influenza B Only Infects Humans |
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August 26, 2011 • Rutgers, The State University of New Jersey |
Histamine Receptor Structure Sheds Light on What Causes Allergies |
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June 23, 2011 • Diamond Light Source |
Researchers Use New Method to Solve Baffling Puzzles in Protein Structure |
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May 1, 2011 • University of Washington |
E. Coli Enzyme Must Move to Function |
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April 7, 2011 • Scripps Research Institute |
Structure Sheds Light on How Sugar Gets Into Cells |
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April 6, 2011 • Technical University of Munich |
Finding of Long-Sought Drug Target Structure May Expedite Drug Discovery |
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March 14, 2011 • National Institutes of Health |
Protein Structure Initiative Study Provides Insights to Medically Important Protein Family |
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March 10, 2011 • Scripps Research Institute |
New Method Can Determine Molecular Structure From Protein Nanocrystals |
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February 3, 2011 • Arizona State University |
NIH Grant to Establish Membrane Protein Structural Biology Consortium |
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November 24, 2010 • Hauptman-Woodward Medical Research Institute |
Molecular Structure of Dopamine Receptor Solved |
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November 16, 2010 • Scripps Research Institute |
Informatics Specialists Helped Reveal Structure of Membrane Protein |
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October 27, 2010 • Technische Universitaet Muenchen |
Atomic Structure Reveals Membrane Protein That Closes Stomata of Plants |
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October 27, 2010 • Brookhaven National Laboratory |
Structural Genomics Research at Synchrotron Begins Exciting New Chapter |
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October 25, 2010 • SLAC National Accelerator Laboratory |
Journal Devotes Issue to Research from Protein Structure Initiative Center |
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October 21, 2010 • Scripps Research Institute |
Study Details Structure of Potential Target for HIV and Cancer Drugs |
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October 7, 2010 • National Institute of General Medical Sciences |
Structure of Protein That Helps Guide Blood Cell Movement Revealed |
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October 4, 2010 • The Scripps Research Institute |
ASU Protein Center to Battle Infectious Diseases |
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September 30, 2010 • Arizona State University |
Einstein Researcher Receives $30 Million NIH Protein Grant |
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September 30, 2010 • Albert Einstein College of Medicine |
Scripps Scientists Receive $65 Million to Reveal Important Proteins’ Form and Function |
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September 30, 2010 • Scripps Research Institute |
New Grant Focuses on Where Structure Meets Function |
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September 30, 2010 • Sanford-Burnham |
Rutgers Awarded $47.5 Million to Advance Protein Structure Research |
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September 30, 2010 • Rutgers University |
NIH Grants Will Advance Studies of the Form and Function of Proteins |
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September 30, 2010 • National Institute of General Medical Sciences |
Caltech Leads $11.5 Million Membrane Protein Center |
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September 30, 2010 • California Institute of Technology |
PSI Structural Genomics Knowledgebase Launches Free Tutorial on Using the Protein Portal |
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March 18, 2010 • PRWEB |
Seams in HIV Coat Could Lead to New Drugs |
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November 12, 2009 • University of PittsburghNIGMS-supported structural biologists have identified functionally important ‘seams’ within the coat that surrounds the HIV genome. |
Scientists Build Complete Metabolic Model |
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September 17, 2009 • Burnham Institute for Medical ResearchNIGMS-supported investigators report the construction of a complete model, including three dimensional protein structures, of the central metabolic network of the bacterium Thermotoga maritima. |
New Project Gives “Shape” to Metabolic Network |
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September 17, 2009 • National Institute of General Medical SciencesPSI-supported researchers have modeled all of the protein structures in an organism’s metabolic network, offering new insights on basic biology and evolution. |
Advancing Protein Studies with Worldwide Software Experiment |
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August 28, 2009 • National Institute of General Medical SciencesThanks in part to large-scale structural biology efforts like the NIGMS Protein Structure Initiative, scientists are launching a community experiment to drive advances in NMR data analysis. |
Structure of HIV's Shell |
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June 15, 2009 • Scripps Research InstituteAn NIGMS-funded study has provided a close-up look at the hexagonal protein building blocks that make up the HIV capsid. |
NIGMS Invites Biologists to Join High-Throughput Structure Initiative |
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February 12, 2009 • National Institute of General Medical SciencesNIGMS announces plans for PSI:Biology, a program to support research partnerships between groups of biologists and high-throughput structure determination centers to solve problems of biomedical importance. |
Structure of Important Neurological Receptor |
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October 6, 2008 • Scripps Research InstituteNIGMS-funded biologists have solved the structure of an adenosine receptor that could lead to drugs for neurological disorders. |
Protein Structure Initiative Discovery Points to Drugs for Flu |
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August 25, 2008 • Rutgers UniversityAn NIGMS-funded collaboration has revealed a key binding pocket for flu infection. Disrupting the interaction could treat flu. |
New Web Portal to Advance Wide Range of Protein Studies |
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April 3, 2008 • National Institute of General Medical SciencesThe Protein Structure Initiative has launched an online resource that will enable scientists from across biomedical disciplines to easily access a wealth of information about proteins. |
Scientists Unveil Structure of Molecular Target of Many Drugs |
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October 29, 2007 • National Institute of General Medical SciencesScientists supported by two major NIH initiatives have captured the first structure of a human G protein-coupled receptor, one of a family of membrane proteins targeted by about half of today's pharmaceuticals. |
Protein Structure Initiative Launches New Resources for the Scientific Community |
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November 6, 2006 • National Institute of General Medical SciencesNow that the Protein Structure Initiative (PSI) has established efficient pipelines for determining the three-dimensional shapes of proteins, it is creating new mechanisms for sharing the resources it has developed with the scientific community. |
NIGMS Announces PSI Molecular Modeling Centers |
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August 10, 2006 • National Institute of General Medical SciencesTwo newly funded molecular modeling centers will develop computational methods for reliably predicting protein structures. |
NIGMS Funds New Center for Molecular Modeling |
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July 20, 2006 • Burnham InstituteA new NIGMS-funded center will improve predictions of three-dimensional protein structures from raw genetic sequence. The center will unite scientists from the Burnham Institute in La Jolla and the University of California, San Diego. |
Scientists Take Snapshots of Enzyme Action |
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June 12, 2006 • Brookhaven National LaboratoryNIGMS-funded researchers have learned the structure and mechanism of an enzyme that eliminates drugs and toxic compounds from the body. Understanding these details could help reveal why such compounds are not always properly eliminated. |
Discovery Could Help Fight Cystic Fibrosis Infection |
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June 9, 2006 • Argonne National LaboratoryNIGMS-supported scientists have solved the structure of a key protein involved in the infections that strike people with cystic fibrosis. The finding provides a possible drug target for fighting these infections. |
Mini-Synchrotron Could Increase Access to Key Research Tool |
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March 2, 2006 • National Institute of General Medical SciencesScientists based in Palo Alto, California, have produced brilliant X-ray light from a device just a fraction of the standard size. The advance could transform numerous fields of biomedical research by vastly improving access to a key resource for studying the properties of molecules. |
Biochemists Detect Proteins' Subtle 'Backrub' Motion |
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February 7, 2006 • Duke UniversityBiochemists have uncovered a new type of protein movement and dubbed it the 'backrub' motion. The team believes the subtle gyration influences proteins' activities in the cell. |
New Approach Offers Proof of Principle for Studying Membrane Proteins |
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October 18, 2005 • National Institute of General Medical SciencesResearchers led by Nobel Prize winner Roderick MacKinnon, M.D., of Rockefeller University have used yeast to express and obtain the structure of a mammalian voltage-dependent potassium ion channel—a type of membrane protein that helps transmit electrical signals into and out of heart and nerve cells. |
UW-Madison Awarded $20 Million Grant for Protein Research |
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July 11, 2005 • Wisconsin Technology Network |
UW-Madison Scientists Receive $20 Million Award for Protein Study |
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July 6, 2005 • University of Wisconsin-Madison |
Rutgers to Lead Project to Learn Protein Structures, Functions |
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July 5, 2005 • Rutgers University |
Columbia University Takes Leading Role in Second Phase of NIH Protein Structure Initiative |
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July 5, 2005 • Columbia University Medical Center |
Scripps Research Institute-Based Center Awarded More than $50 Million by NIH in Massive Effort to Solve Protein Structures |
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July 1, 2005 • Scripps Research Institute |
Protein Structure Initiative Advances to Rapid Production Phase |
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July 1, 2005 • National Institute of General Medical Sciences |
Einstein Researchers Receive Major Federal Grant to Decipher the Three-Dimensional Shapes of Proteins |
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July 1, 2005 • Albert Einstein College of Medicine |
Awards Announced for Protein Structures |
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July 1, 2005 • Science Now |
Protein Structure Initiative Advances to Rapid Production Phase |
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July 1, 2005 • Brookhaven National Lab |
Structural GenomiX Receives $48.5 Million Award From NIH |
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July 1, 2005 • Structural GenomiX |
Research of Proteins Draw Major Funding |
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July 1, 2005 • San Diego Union Tribune |
Researchers Debut New X-Ray Resources for Studying Molecules |
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June 23, 2005 • National Institute of General Medical Sciences |
The Shapes of Life: NIGMS Project Yields More Than 1,000 Protein Structures |
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February 10, 2005 • National Institute of General Medical SciencesThe Protein Structure Initiative, an NIGMS program aimed at determining the three-dimensional shapes of a wide range of proteins, has now determined more than 1,000 different structures. These structures will shed light on how proteins function in many life processes and could lead to targets for the development of new medicines. |
Scientists Develop Split Green for Tagging Protein |
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January 3, 2005 • Los Alamos National Laboratory |
Energy Secretary Recognizes Project Management Awardees |
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August 17, 2004 • Department of Energy |
Brookhaven Lab Biophysicist F. William Studier Wins R&D 100 Award for a New Method that Simplifies Protein Production |
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July 28, 2004 • Brookhaven National Laboratory |
Scientists Take 'Snapshot' of Molecular Tether for Anthrax and Staph Bacteria |
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July 19, 2004 • National Institute of General Medical Sciences |
Argonne Scientists Determine Structure of Staph, Anthrax Enzyme |
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July 14, 2004 • Argonne National Laboratory |
New Computational Tools to Aid in Protein Research |
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June 23, 2004 • Dartmouth College |
Crystallographers Take Note: a Synchrotron Light Source for Your Home Lab |
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April 16, 2004 • Lyncean Technologies, Inc. |
Robots Score Big with Protein Crystallographers |
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April 9, 2004 • Lawrence Berkeley National Laboratory |
'Crystal Engineering' Helps Scientists Solve 3-D Protein Structures |
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April 6, 2004 • National Institute of General Medical Sciences |
Dazzling New Light Source Opens at Stanford Synchrotron Radiation Laboratory |
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January 30, 2004 • Stanford University |
Protein Data Bank Opens New Era with Broader Support -- Nearly 24,000 Molecules and Growing, Accessible Collection Advances Biology |
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January 21, 2004 • National Science Foundation |
Anthrax Toxin Structure Solved |
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April 2, 2003 • National Institute of General Medical Sciences |
Protein Structure Initiative Center Maps Protein Universe |
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March 3, 2003 • National Institute of General Medical Sciences |
"Knot" to be Undone, Researchers Discover Unusual Protein Structure |
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November 26, 2002 • National Institute of General Medical Sciences |
Protein Structure Initiative |
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October 3, 2001 • National Institute of General Medical Sciences |
NIGMS Protein Structure Initiative Announces New Members |
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September 28, 2001 • National Institute of General Medical Sciences |
Structural Genomics: Inside the Cutting Edge |
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June 1, 2001 • National Institute of General Medical Sciences |
From Genes to Proteins: NIGMS Catalogs the Shapes of Life |
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February 20, 2001 • National Institute of General Medical Sciences |
NIGMS Structural Genomics Awards Scale Up Protein Structure Studies |
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September 26, 2000 • National Institute of General Medical Sciences |
Ten Thousand Protein Structures: The First Goal of Structural Genomics |
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June 2, 2000 • National Institute of General Medical Sciences |
NIGMS Announces Initiative on Structural Genomics |
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June 23, 1999 • National Institute of General Medical Sciences |