for Health Care Providers

HIV Meds Quarterly

HIV Meds Quarterly provides brief updates and analysis of new findings related to common therapies used by HIV clinicians.

Research Briefs: Pitavastatin and Darunavir/Ritonavir; Dolutegravir in Initial Therapy: Two Phase 3 Studies; Cobicistat as a PK Booster of Atazanavir; Elvitegravir as Effective as Raltegravir in Treatment-Experienced Patients
Fast Takes: The "quad" pill, ARV generics, Truvada/PrEP approval
Reference Table: Updates to the Database of ARV Drug Interactions

Research Briefs: Once-Daily Etravirine; Switching from Efavirenz to Rilpivirine; Darunavir + Raltegravir without NRTIs, Revisited
Fast Takes: Rilpivirine Added to DHHS Recommendations; Raltegravir-Associated Skin Reactions; Darunavir Oral Suspension

Interactions: Buprenorphine/Naloxone with Raltegravir; Pitavastatin with Lopinavir/Ritonavir; Sustained Effect of Efavirenz on Rilpivirine Serum Concentrations; Hepatitis C NS3 Protease Inhibitors and Antiretroviral Drugs
Research Briefs: Preexposure Prophylaxis with Oral Tenofovir or Tenofovir/Emtricitabine; Dolutegravir in Treatment-Naive Patients; Lersivirine: A New NNRTI
Reference Table: Updates to the Database of ARV Drug Interactions

Research Briefs: Darunavir + Raltegravir without NRTIs; Raltegravir: Inferior Results with Once-Daily Dosing; Hepatitis C Infection and Telaprevir; Rilviripine Redux
Fast Takes: Darunavir dosage in treatment-experienced patients
Reference Table: Updates to the Database of ARV Drug Interactions

Interactions: Rosuvastatin Levels Increased by Ritonavir-Boosted Darunavir; Fosamprenavir and Posaconazole
Research Briefs: Recent Advances in Once-Daily Therapies and Fixed-Dose Combination Regimens: Rilpivirine (TMC278) in Initial Therapy; S/GSK 572 in Initial Therapy: Interim Results of SPRING-1; Efficacy and Safety of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir ("Quad" Pill) in Initial Therapy; Novel Pharmacokinetic Booster Cobicistat (GS-9350)
Fast Takes: Maraviroc in patients with kidney disease; Didanosine and noncirrhotic portal hypertension
Reference Table: Updates to the Database of ARV Drug Interactions

Interactions: Efavirenz and Levonorgestrel; Lopinavir/ritonavir and Buprenorphine
Research Brief: Vicriviroc in Treatment-Experienced Patients
Fast Takes: Ritonavir tablet formulation; Maraviroc approved for initial therapy; Saquinavir/ritonavir and possible risk of abnormal heart rhythms
Reference Table: Updates to the Database of ARV Drug Interactions

Research Briefs: Kaletra Dosage Adjustment for Patients on Efavirenz or Nevirapine; Once-Daily Raltegravir; Atazanavir and Lopinavir/Ritonavir in Hemodialysis
Reference Table: Updates to the Database of ARV Drug Interactions

Research Briefs: Regimen Simplification: Atazanavir vs Atazanavir/Ritonavir; Atazanavir/Ritonavir in Pregnancy; Investigational Integrase Inhibitor Shows Potent Activity in Early Studies
Reference Table: Updates to the Database of ARV Drug Interactions
Fast Takes: Raltegravir approved for initial therapy

Research Briefs: Rosiglitazone and Heart Disease; Antipsychotics and Sudden Cardiac Death; New Pharmacokinetic Booster on the Horizon; Interleukin-2: No Clinical Benefit; Raltegravir Substitution for Lopinavir/Ritonavir (SWITCHMRK Study); Abacavir and Myocardial Infarction Risk: Additional Data
Reference Table: Updates to the Database of ARV Drug Interactions
Fast Takes: Darunavir: Traditional approval
Guidelines: New Guidelines: Adult OI prevention and treatment; Updated: Pediatric ARV guidelines; Updated: Perinatal guidelines

Research Briefs: Darunavir Approved for Use with Boosted Ritonavir as "Preferred" PI, Pediatric Dosing
Fast Takes: Recent news about maraviroc, abacavir: pediatric formulation, and abacavir/lamivudine: DHHS recommendations

Research Briefs: Pregabalin for Neuropathic Pain: Not More Effective Than Placebo; Abacavir/Lamivudine: Higher Rates of Virologic Failure in ARV-Naive Patients with HIV RNA ≥100,000 copies/mL compared with Tenofovir/Emtricitabine; Abacavir and Risk of Myocardial Infarction: The SMART Study
Interactions: Atazanavir: Interactions with Efavirenz, Nevirapine, and Oral Hormonal Contraceptives
Fast Takes: Recent news about ritonavir, darunavir, atazanavir + ritonavir, tenofovir, zidovudine, and didanosine

Research Briefs: Abacavir and Didanosine Associated with Increased Risk of Myocardial Infarction; Testing for Chemokine Coreceptor Tropism
Interactions: Rosuvastatin with Lopinavir/Ritonavir and Tipranavir; Rifampin and "Super-Boosted" Protease Inhibitors
Fast Takes: Recent news about nelfinavir, tipranavir, lopinavir/ritonavir, and nevirapine

Research Briefs: Atazanavir Efficacy Data and Changes in Dosage Recommendations; Raltegravir Substitution for Enfuvirtide; HLA-B*5701 Screening
Reference Table: Etravirine-ARV Interactions
Fast Takes: Recent news about darunavir, lamivudine, lopinavir/ritonavir and amprenavir