Drug resistant infections beat by natural compound1333436400000Natural compound beats drug resistant infectionsResearchers have discovered and isolated a naturally occurring compound that is highly effective at eliminating growth of gram positive and gram negative bacteria in vitro. http://farm9.staticflickr.com/8019/7645495008_07f43ddf52_b.jpgOrange and black swirl of lightNatural compound provides low-cost therapeutics to treat multi-drug resistant infections.http://farm9.staticflickr.com/8019/7645495008_07f43ddf52_s.jpgIt's like rehab for pathogensDrug-resistent infections are given the tough-love treatment with a natural compound that is effective against a broad spectrum of bacteria.
Tech Transfer: Problem Solved!Drug resistant infections beat by naturally occurring compound
Applications:
- Effective treatment of drug
resistant pathogens
Benefits:
- Useful against a broad spectrum of bacteria
- Unique structure is amenable
to synthesis
- Unique structure will make
development of resistance difficult
Summary:
A
team of Los Alamos researchers has discovered and isolated a naturally occurring compound that is highly effective at eliminating growth of gram positive
and gram negative bacteria in vitro. The team analyzed the organism that
naturally produces the compound to determine the genetically encoded components
if the enzymatic cluster associated with the biosynthesis of this natural
product. Subsequently, using bioinformatics, this information was used to
interrogate databases of known sequences from other organisms and identify
similar assembly lines that produce structurally similar compounds. The natural
products from these newly identified organisms are structurally different from
any known antibacterials. We believe these natural produces are amenable to
cost-effective chemical synthesis methodologies to increase their diversity and
to provide low-cost therapeutics to treat multi-drug resistant infections.
Development stage: Multiple
organisms that produce these natural products are being cultured to synthesize
adequate quantities of bioactive compounds from each with which to conduct
toxicological and mutagenicity studies in human cell lines.
Intellectual property status: Patent application pending.
Licensing status: Los Alamos is seeking commercial partners
to co-develop the technology.
/We believe these natural produces are amenable to cost-effective chemical synthesis methodologies to increase their diversity and to provide low-cost therapeutics to treat multi-drug resistant infections.YesContact/David HadleyTechnology Transfer(505) 667-7539dhadley@lanl.gov Drug resistant infections beat by natural compound
Researchers have discovered and isolated a naturally occurring compound that is highly effective at eliminating growth of gram positive and gram negative bacteria in vitro.
April 3, 2012
Natural compound provides low-cost therapeutics to treat multi-drug resistant infections.
We believe these natural produces are amenable to cost-effective chemical synthesis methodologies to increase their diversity and to provide low-cost therapeutics to treat multi-drug resistant infections.
Drug resistant infections beat by naturally occurring compound
Applications:
- Effective treatment of drug
resistant pathogens
Benefits:
- Useful against a broad spectrum of bacteria
- Unique structure is amenable
to synthesis
- Unique structure will make
development of resistance difficult
Summary:
A
team of Los Alamos researchers has discovered and isolated a naturally occurring compound that is highly effective at eliminating growth of gram positive
and gram negative bacteria in vitro. The team analyzed the organism that
naturally produces the compound to determine the genetically encoded components
if the enzymatic cluster associated with the biosynthesis of this natural
product. Subsequently, using bioinformatics, this information was used to
interrogate databases of known sequences from other organisms and identify
similar assembly lines that produce structurally similar compounds. The natural
products from these newly identified organisms are structurally different from
any known antibacterials. We believe these natural produces are amenable to
cost-effective chemical synthesis methodologies to increase their diversity and
to provide low-cost therapeutics to treat multi-drug resistant infections.
Development stage: Multiple
organisms that produce these natural products are being cultured to synthesize
adequate quantities of bioactive compounds from each with which to conduct
toxicological and mutagenicity studies in human cell lines.
Intellectual property status: Patent application pending.
Licensing status: Los Alamos is seeking commercial partners
to co-develop the technology.
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