Substances |
PDN Description |
Status (1) |
Acrolein |
- Exposure levels in humans living near hazardous waste sites and
other populations
- Exposure levels in children
- Dose-response data for chronic-duration(4) via
inhalation exposure
|
Unfilled |
Aldrin/Dieldrin |
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Aluminum |
- Dose-response data for acute-duration(2) via oral exposure
- Exposure via environmental media for humans living near hazardous
waste sites
- Exposure via environmental media for children living near hazardous
waste sites
- Exposure via environmental media for adults and children who do not
live near hazardous waste sites (as controls)
|
Unfilled |
Arsenic |
- Comparative toxicokinetic studies to determine if an appropriate
animal species can be identified
- Half-lives in surface water, groundwater
|
Unfilled |
Asbestos |
- Epidemiologic studies of individuals occupationally exposed to
asbestos levels lower than those experienced before the institution
of current occupational standards governing the use of asbestos,
but higher than current levels in the general population.
These studies should be performed in conjunction with the immunotoxicity
studies
- Immunotoxicity studies of individuals occupationally exposed to
asbestos
- Development of human and rat lung retention models to aid in extrapolating
between rat and human data
- Exposure levels, fiber size distribution, and asbestos fiber type
in areas with natural geologic deposits of friable asbestos and
at hazardous waste sites. Also, techniques for estimating
air levels of asbestos from soil concentrations and activity scenarios
- Exposure levels in humans living near hazardous waste sites and
in other populations, such as humans living in areas with naturally
high levels of friable asbestos
|
Unfilled |
Barium |
- Dose- response data for acute-duration(2) via oral
exposure
|
Unfilled |
Benzene |
- Dose-response data in animals for acute- and intermediate(3)-duration
oral exposure. The intermediate-duration study should include an
extended reproductive organ histopathology
- Prenatal developmental toxicity study via oral exposure
- Neurotoxicology battery of tests via oral exposure
|
Unfilled |
Benzidine |
- Dose-response data for acute- and intermediate-duration exposure
via the oral route (the study of intermediate-duration exposure
should include evaluation of reproductive and endocrine organ histopathology,
lymphoid tissues histopathology as well as examination of relevant
blood components, and nervous system histopathology)
- Exposure levels in humans living near hazardous waste sites
- Exposure levels in children
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Beryllium |
- Dose-response data in animals for acute- and intermediate-duration
inhalation exposures. The intermediate-duration study should include
extended reproductive organ histopathology
- Prenatal developmental toxicity study via inhalation exposure
- Environmental fate in air; factors affecting bioavailability in
air
- Immunotoxicology battery of tests following oral exposure
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Carbon tetrachloride |
- Dose-response data in animals for chronic oral exposure. The study
should include extended reproductive organ and nervous tissue histopathology
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Chlordane |
- Bioavailability studies following ingestion of contaminated media
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Chlorinated dibenzo-p-dioxins (CDDs) |
- Comparative toxicokinetic studies examining the relative absorption
of CDDs across exposure routes and the relative contribution of
each exposure route to total body burdens
|
Unfilled |
Chloroethane |
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Chloroform |
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Chromium |
- Dose-response data in animals for acute-duration exposure to chromium
(III) via oral exposure
- Multigeneration reproductive toxicity study via oral exposure
to chromium (III)
- Immunotoxicology battery of tests following oral exposure to chromium
(III) and (VI)
- Prenatal developmental toxicity study via oral exposure to chromium
(III)
|
Unfilled |
Cresols |
- Dose-response data for acute-duration via oral exposure
- Exposure levels in humans living near hazardous waste sites and other
populations
- Exposure levels in children
|
Unfilled |
Cyanide |
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Diazinon |
- Developmental toxicity data via oral exposure
|
Unfilled |
1,2-dibromo-3-chloropropane |
- Dose-response data in animals for acute-duration exposure via
the oral route (including reproductive organ histopathology)
- Dose-response data in animals for chronic-duration exposure via
the oral route (including reproductive organ histopathology)
- Prenatal developmental toxicity study via oral exposure
- Immunotoxicology testing battery via oral exposure
- Neurotoxicology testing battery via oral exposure
- Potential candidate for subregistry of exposed persons
|
Unfilled |
1,2-Dibromoethane |
- Dose-response data in animals for intermediate-duration exposure
by the oral route (the study should include evaluation of neuropathology
and observation for overt signs of neurotoxicity)
- Multigeneration reproductive toxicity studies via oral exposure
- Prenatal toxicity studies via oral exposure
- Exposure levels in humans living near hazardous waste sites and
in other populations, such as workers exposed to 1,2-dibromoethane
- Exposure levels in children
- Potential candidate for subregistry of exposed persons
|
Unfilled |
1,2-Dichloroethane |
- Dose-response data in animals for acute-duration exposure by the
inhalation route, including a comparison of young and adult animals
- Dose-response data in animals for acute-duration exposure by the
oral route, including a comparison of young and adult animals
- Dose-response data in animals for intermediate-duration exposure
by the inhalation route (the study should be performed in conjunction
with the neurotoxicology battery of tests)
- Neurotoxicology battery of tests following oral exposure
- Dose-response data in animals for chronic-duration exposure by
the oral route
- Prenatal developmental toxicity data for inhalation exposure (assessment
of developmental cardiotoxicity and neurotoxicity)
- Prenatal developmental toxicity data for oral exposure (assessment
of developmental cardiotoxicity and neurotoxicity)
- Additional analyses and studies for comparative toxicokinetics
across species, ages, routes, and durations
- Children’s susceptibility
- Exposure levels in children
- Potential candidate for subregistry of exposed persons
|
Unfilled |
1,1-Dichloroethene |
- Carcinogenicity studies in two species following inhalation exposure
- Reproductive toxicity studies assessing male and female end points
following inhalation exposure
- Immunotoxicology battery of tests following oral exposure
- Battery of neurobehavioral tests following inhalation exposure
- Children’s susceptibility
- Exposure levels in children
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Dichloropropenes |
- Dose-response data for acute-duration via inhalation exposure
- Immunotoxicity battery via inhalation exposure
|
Unfilled |
DDT |
- Dose-response data in animals for chronic-duration oral exposure
- Comparative toxicokinetic study (across routes/species)
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Di(2-ethylhexyl) phthalate |
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Di-n-butyl phthalate |
- Dose-response data in animals for chronic-duration exposure via
the oral route
- Carcinogenicity studies via oral exposure
- Bioavailability in contaminated environmental media near hazardous
waste sites
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Disulfoton |
- Exposure levels of disulfoton in tissues/fluids for populations
living near hazardous waste sites and other populations, such as
exposed workers
- Disulfoton should be considered as a potential candidate for a
subregistry of exposed persons
|
Unfilled |
Endosulfan (α,β, and sulfate) |
- Acute-duration oral exposure studies
- Data on sensitive neurologic end points following oral exposure
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Endrin/endrin aldehyde |
- Dose-response animal data for acute oral exposure to endrin
- Multigeneration reproductive toxicity studies via oral exposure
to endrin
- Accurately describe the toxicokinetics of endrin and its degradation
products and identify the animal species to be used as the most
appropriate model for human exposure
- Accurately describe the environmental fate of endrin, including
environmental breakdown products and rates, media half-lives, and
chemical and physical properties of the breakdown products that
help predict mobility and volatility
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Ethylbenzene |
- Dose-response data for acute-duration exposure by the oral route
- Prenatal developmental study with continued assessment of offspring
during postnatal development following oral exposure
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Guthion |
- Studies of developmental toxicity via oral exposure with emphasis
on neurodevelopmental toxicity.
|
Unfilled |
Heptachlor/
heptachlor epoxide |
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Hexachlorobutadiene |
- Dose-response data in animals for acute-duration exposure via
the oral route
- Exposure levels in humans living near hazardous waste sites and
other populations, such as exposed workers
- Environmental fate studies that determine the extent to which
hexachlorobutadiene volatilizes from soil, and studies that determine
the reactions and rates which drive degradation in soil
- Bioavailability studies in soil and plants
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Hexachlorocyclohexane (α, β, γ, and δ)
|
- Mechanistic studies on the reproductive toxicity and immunotoxicity
of hexachlorocyclohexane
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Manganese |
- Relative bioavailability of different manganese compounds and
bioavailability of manganese from soil
|
Unfilled |
Mercury |
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Methoxychlor |
- Exposure levels of methoxychlor and primary metabolites in humans
living near hazardous waste sites and in those individuals with
the potential to ingest it
- Evaluate the fate, transport, and levels of the degradation products
of methoxychlor in soil
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Methylene chloride |
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Nickel |
- Dose-response data in animals for acute- and intermediate-duration
oral exposures
- Neurotoxicology battery of tests via oral exposure
- Bioavailability of nickel from soil
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Pentachlorophenol |
- Comparative toxicokinetic studies
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Phenol |
- Exposure levels in humans living near hazardous waste sites and other
populations
- Exposure levels in children
|
Unfilled |
Polychlorinated biphenyls (PCBs) |
- Biodegradation of PCBs in water; bioavailability of PCBs in air,
water, and soil
- Dose-response data in animals for acute- and intermediate-duration
inhalation exposures. The intermediate-duration study should include
extended reproductive organ histopathology
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Polycyclic aromatic hydrocarbons (PAHs)
(Includes 15 substances) |
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Selenium |
- Dose-response data in animals for acute-duration oral exposure
- Immunotoxicology battery of tests via oral exposure
- Potential candidate for subregistry of exposed persons
|
Unfilled |
1,1,2,2-Tetrachloroethane |
- Prenatal developmental toxicity study by the oral route
- Immunotoxicity battery following oral exposure
- Mammalian in vivo genotoxicity assays
- Exposure levels in children
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Tetrachloroethylene |
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Toluene |
- Potential candidate for subregistry of exposed persons
- Neurotoxicology battery of tests via oral exposure
|
Unfilled |
Toxaphene |
- Identify the long-term health consequences of exposure to environmental
toxaphene via oral exposure
- Neurotoxicity studies for chronic-duration via oral route of exposure
- Exposure levels in humans living in areas near hazardous waste
sites with toxaphene and in those individuals with the potential
to ingest it
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Vinyl chloride |
- Dose-response data in animals for chronic-duration inhalation
exposure
- Mitigation of vinyl chloride-induced toxicity
- Exposure levels in humans living near hazardous waste sites and
other populations, such as exposed workers
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Xylenes |
- Neurotoxicology battery of tests following oral exposure
- Two-generation reproductive study following oral exposure
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Zinc |
- Carcinogenicity testing (2-year bioassay) via oral exposure
- Exposure levels in humans living near hazardous waste sites and
other populations, such as exposed workers
- Potential candidate for subregistry of exposed persons
|
Unfilled |