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Human Health-Based Water Guidance Table

The Minnesota Department of Health (MDH) develops health-based rules and guidance to evaluate potential human health risks from exposures to chemicals in groundwater. For more information, see: Health-Based Guidance for Water or contact the Health Risk Assessment Unit .

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Key to table entries

Value Type: HRL = Health Risk Limits; HBV = Health-Based Values; and RAA = Risk Assessment Advice. Subscripts either indicate the last two digits of the year the value was developed or that the HRL is based on a US EPA Maximum Contaminant Level (MCL).

Exposure Duration: Acute = one day exposure; Short-term = greater than one day up to 30 days; Subchronic = greater than 30 days up to 10% of a lifetime; Chronic = greater than 10% of a lifetime; and Cancer = zero to 70 years of age

Guidance Table

CAS Number	Chemical	Value Type	Exposure Duration	Value (µg/L)	Health Endpoint(s)
Find chemicals beginning with: A - C D - E F - M N - S T - Z
83-32-9	Acenaphthene Toxicological Summary for Acenaphthene (PDF) Information Sheet: Acenaphthene in Drinking Water (PDF)	HRL₉₃	Chronic	400	Liver system
		HBV₁₅	Chronic	400	Liver system
			Acute	ND	--
			Short-term	ND	--
			Subchronic	200	Adrenal; Liver system
			Chronic	100	Adrenal; Liver system
			Cancer	N/A	--
103-90-2	Acetaminophen Toxicological Summary for Acetaminophen (PDF) Information Sheet: Acetaminophen in Drinking Water (PDF)	HRL₁₅	Acute	200	Liver system
			Short-term	200	Liver system
			Subchronic	200*	Liver system
			Chronic	200*	Liver system
			Cancer	N/A	--
34256-82-1	Acetochlor Toxicological Summary for Acetochlor (PDF) See also degradates: Acetochlor ESA Acetochlor OXA	HRL₀₉	Acute	40	Developmental
			Short-term	40	Developmental
			Subchronic	40*	Developmental
			Chronic	9	Liver system; Male reproductive system; Nervous system; Kidney system; Respiratory system
			Cancer	NA	--
187022-11-3	Acetochlor ESA Toxicological Summary for Acetochlor ESA (PDF) (degradate of Acetochlor)	HRL₁₁	Acute	ND	--
			Short-term	600	Thyroid (E)
			Subchronic	600	Thyroid (E)
			Chronic	300	Thyroid (E)
			Cancer	NA	--
194992-44-4	Acetochlor OXA Toxicological Summary for Acetochlor OXA (PDF) (degradate of Acetochlor)	HRL₁₁	Acute	ND	--
			Short-term	200	Thyroid (E)
			Subchronic	200	Thyroid (E)
			Chronic	100	Thyroid (E)
			Cancer	NA	--
67-64-1	Acetone Toxicological Summary for Acetone (PDF)	HRL₁₁	Acute	ND	--
			Short-term	9,000	Kidney system
			Subchronic	8,000	Kidney system; Blood system
			Chronic	4,000	Kidney system; Blood system
			Cancer	NA	--
21145-77-7 or 1506-02-1	6-Acetyl-1,1,2,4,4,7-hexamethyltetraline (AHTN or Tonalide) Toxicological Summary for 6-Acetyl-1,12,4,4,7-hexamethyltetraline (PDF) Information Sheet: AHTN in Drinking Water (PDF)	HRL₁₃	Acute	ND	--
			Short-term	100	Liver system
			Subchronic	30	Liver system
			Chronic	20	Liver system
			Cancer	NA	--
79-06-1	Acrylamide Toxicological Summary for Acrylamide (PDF) Information Sheet: Acrylamide in Drinking Water (PDF)	HRL₁₅	Acute	ND	--
			Short-term	7	Developmental; Male reproductive system; Nervous system
			Subchronic	7*	Developmental; Male reproductive system; Nervous system
			Chronic	7*	Developmental; Male reproductive system; Nervous system
			Cancer	0.2	Cancer
15972-60-8	Alachlor Toxicological Summary for Alachlor (PDF) See also degradates Alachlor ESA Alachlor OXA	HRL₀₉	Acute	ND	--
			Short-term	200	Kidney system
			Subchronic	30	Blood system; Liver system
			Chronic	5	Blood system; Liver system
			Cancer	NA	--
142363-53-9	Alachlor ESA Toxicological Summary for Alachlor ESA (PDF) (degradate of Alachlor)	RAA₁₆	Acute	ND	--
			Short-term	ND	--
			Subchronic	100	Blood system
			Chronic	50	Blood system
			Cancer	NA	--
171262-17-2	Alachlor OXA Toxicological Summary for Alachlor OXA (PDF) (degradate of Alachlor)	RAA₁₆	Acute	ND	--
			Short-term	ND	--
			Subchronic	100	Blood system
			Chronic	50	Blood system
			Cancer	NA	--
116-06-3	Aldicarb	HRL₉₃	Chronic	1	Nervous system
107-05-1	Allyl chloride (3 chloropropene)	HRL₉₄	Chronic	30	Nervous system
64285-06-9	Anatoxin-a Toxicological Summary for Anatoxin-a (PDF) Information Sheet: Anatoxin-a in Drinking Water (PDF)	RAA₁₆	Acute	ND	--
			Short-term	0.1	Nervous system
			Subchronic	ND	--
			Chronic	ND	--
			Cancer	ND	--
120-12-7	Anthracene	HRL₉₃	Chronic	2,000	None
7440-36-0	Antimony	HRL₉₃	Chronic	6	--
1912-24-9	Atrazine	HRL_MCL	Chronic	3	see USEPA Organic Chemicals table
7440-39-3	Barium	HRL₉₃	Chronic	2,000	Cardiovascular system
25057-89-0	Bentazon Toxicological Summary for Bentazon (PDF) Information Sheet: Bentazon in Drinking Water (PDF)	HRL₁₅	Acute	400	Developmental; Female reproductive system
			Short-term	60	Developmental
			Subchronic	50	Blood system
			Chronic	30	Thyroid
			Cancer	NA	--
71-43-2	Benzene Toxicological Summary for Benzene (PDF)	HRL₀₉	Acute	10	Developmental
			Short-term	10	Blood system; Immune system
			Subchronic	3	Blood system; Immune system
			Chronic	3**	Blood system; Immune system
			Cancer	2	Cancer
50-32-8	Benzo[a]pyrene Toxicological Summary for Benzo(a)pyrene (PDF) Information Sheet: Benzo(a)pyrene in Drinking Water (PDF)	HBV₁₂	Acute	2	Developmental
			Short-term	0.3	Developmental
			Subchronic	0.3*	Developmental
			Chronic	0.3*	Developmental
			Cancer	0.06	Cancer
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65-85-0	Benzoic acid	HRL₉₃	Chronic	30,000	None
7440-41-7	Beryllium	HRL₉₃	Cancer	0.08	Cancer
92-52-4	1,1-Biphenyl (Diphenyl)	HRL₉₃	Chronic	300	Kidney system
111-44-4	Bis(chloroethyl) ether (BCEE)	HRL₉₃	Cancer	0.3	Cancer
542-88-1	Bis(chloromethyl) ether (BCME)	HRL₉₃	Cancer	0.002	Cancer
80-05-7	Bisphenol A (BPA) Toxicological Summary for Bisphenol A (PDF) Information Sheet: Bisphenol A in Drinking Water (PDF)	HRL₁₅	Acute	ND	--
			Short-term	100	Developmental; Female reproductive system (E); Liver system; Male reproductive system (E); Kidney system; Thyroid (E)
			Subchronic	20	Liver system; Kidney system
			Chronic	20**	Liver system; Kidney system
			Cancer	NA	--
7440-42-8	Boron
7440-42-8	Boron	RAA₀₈	Chronic	1,000	Developmental
75-27-4	Bromodichloromethane	HRL₉₃	Cancer	6	Cancer
75-25-2	Bromoform	HRL₉₃	Cancer	40	Cancer
74-83-9	Bromomethane (Methyl bromide)	HRL₉₃	Chronic	10	Gastrointestinal system
71-36-3	n-Butanol	HRL₉₃	Chronic	700	Nervous system
85-68-7	Butyl benzyl phthalate (BBP) Toxicological Summary for Butyl benzyl phthalate (PDF) Information Sheet: Phthalates and Drinking Water (PDF)	HRL₁₅	Acute	100	Developmental (E)
			Short-term	100	Developmental (E)
			Subchronic	100*	Developmental (E)
			Chronic	100*	Developmental (E)
			Cancer	NA	--
85-70-1	Butylphthalyl butylglycolate (BPBG)	HRL₉₃	Chronic	7,000	None
7440-43-9	Cadmium Toxicological Summary for Cadmium (PDF) Information sheet: Cadmium and Drinking Water (PDF)	HRL₁₅	Acute	5	Developmental
			Short-term	1	Developmental; Nervous system; Renal (kidney) system
			Subchronic	1	Developmental; Skeletal
			Chronic	0.5	Renal (kidney) system; Skeletal
			Cancer	NA	--
298-46-4	Carbamazepine Toxicological Summary for Carbamazepine (PDF) Information Sheet: Carbamazepine in Drinking Water (PDF)	HRL₁₃	Acute	40	Developmental; Nervous system
			Short-term	40	Developmental; Blood system; Liver system; Immune system; Nervous system; Male reproductive system (E); Female reproductive system (E); Thyroid (E)
			Subchronic	40*	Developmental; Blood system; Liver system; Immune system; Nervous system; Male reproductive system (E); Female reproductive system (E);Thyroid (E)
			Chronic	40*	Developmental; Blood system; Liver system; Immune system; Nervous system; Male reproductive system (E); Female reproductive system (E); Thyroid (E)
			Cancer	NA	--
75-15-0	Carbon disulfide	HRL₉₃	Chronic	700	Developmental
56-23-5	Carbon tetrachloride Toxicological Summary for Carbon tetrachloride (PDF)	HRL₁₃	Acute	100	Developmental; Liver system
			Short-term	3	Liver system
			Subchronic	3*	Liver system
			Chronic	3*	Liver system
			Cancer	1	Cancer
133-90-4	Chloramben	HRL₉₄	Chronic	100	Liver system
108-90-7	Chlorobenzene	HRL₉₃	Chronic	100	Liver system
75-00-3	Chloroethane Toxicological Summary for Chloroethane (PDF)	RAA₁₆	Acute	ND	--
			Short-term	ND	--
			Subchronic	ND	--
			Chronic	ND	--
			Cancer	NA	--
67-66-3	Chloroform Toxicological Summary for Chloroform (PDF)	HRL₀₉	Acute	ND	--
			Short-term	30	Developmental; Liver system; Immune system
			Subchronic	30*	Developmental; Liver system; Immune system; Male reproductive system
			Chronic	30*	Developmental; Liver system; Immune system; Male reproductive system
			Cancer	NA	--
95-57-8	2-Chlorophenol	HRL₉₃	Chronic	30	Developmental
1897-45-6	Chlorothalonil	HRL₉₄	Cancer	30	Cancer
2921-88-2	Chlorpyrifos Toxicological Summary for Chlorpyrifos (PDF) Information Sheet: Chlorpyrifos and Drinking Water (PDF)	HBV₁₃	Acute	2	Nervous system
			Short-term	0.6	Nervous system
			Subchronic	0.6*	Nervous system
			Chronic	0.6*	Nervous system
			Cancer	NA	--
5598-15-2	Chlorpyrifos Oxon (degradate of Chlorpyrifos) Toxicological Summary for Chlorpyrifos Oxon (PDF) Information Sheet: Chlorpyrifos and Drinking Water (PDF)	RAA₁₃	Acute	0.9	Nervous system
			Short-term	0.4	Nervous system
			Subchronic	0.4*	Nervous system
			Chronic	0.4*	Nervous system
			Cancer	NA	--
16065-83-1	Chromium III	HRL₉₄	Chronic	20,000	None
18540-29-9	Chromium VI	HRL₉₃	Chronic	100	None
210880-92-5, 205510-53-8	Clothianidin Toxicological Summary for Clothianidin (PDF) Information Sheet: Clothianidin and Drinking Water (PDF)	HBV₁₆	Acute	ND	--
			Short-term	200	Developmental
			Subchronic	200*	Developmental
			Chronic	200*	Developmental
			Cancer	NA	--
98-82-8	Cumene (Isopropyl benzene)	HRL₉₃	Chronic	300	None
21725-46-2	Cyanazine Toxicological Summary for Cyanazine (PDF)	HRL₀₉	Acute	2	Developmental, Female reproductive system
			Short-term	2	Developmental, Female reproductive system
			Subchronic	2	Liver system; Kidney system
			Chronic	1	None
			Cancer	NA	--
57-12-5	Cyanide, free	HRL₉₃	Chronic	100	Nervous system; Thyroid (E)
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93413-62-8, 386750-22-7, 300827-87-6, 93414-04-1	Desvenlafaxine Toxicological Summary for Desvenlafaxine (PDF) Information Sheet: Venlafaxine and Desvenlafaxine and Drinking Water (PDF)	HBV₁₅	Acute	ND	--
			Short-term	20	Developmental; Gastrointestinal system; Male reproductive system; Nervous system (E)
			Subchronic	20*	Developmental; Gastrointestinal system; Male reproductive system; Nervous system (E)
			Chronic	20*	Developmental; Gastrointestinal system; Male reproductive system; Nervous system (E)
			Cancer	NA	--
124-48-1	Dibromochloromethane	HRL₉₃	Chronic	10	Liver system
106-93-4	1,2-Dibromoethane (ethylene dibromide, EDB)	HRL₉₃	Cancer	0.004	Cancer
84-74-2	Dibutyl phthalate (DBP) Toxicological Summary for Dibutyl phthalate (PDF) Information Sheet: Phthalates and Drinking Water (PDF)	HRL₁₅	Acute	20	Developmental (E)
			Short-term	20	Developmental (E)
			Subchronic	20*	Developmental (E)
			Chronic	20*	Developmental (E)
			Cancer	NA	--
1918-00-9	Dicamba	HRL₉₃	Chronic	200	Developmental
95-50-1	1,2-Dichlorobenzene	HRL₉₃	Chronic	600	Liver system
106-46-7	1,4-Dichlorobenzene (para)	HRL₉₄	Cancer	10	Cancer
91-94-1	3,3'-Dichlorobenzidine	HRL₉₃	Cancer	0.8	Cancer
75-71-8	Dichlorodifluoromethane Toxicological Summary for Dichlorodifluoromethane (PDFs)	HRL₁₁	Acute	ND	--
			Short-term	ND	--
			Subchronic	ND	--
			Chronic	700	None
			Cancer	NA	--
72-54-8	p,p'-Dichlorodiphenyldichloroethane (DDD)	HRL₉₃	Cancer	1	Cancer
72-55-9	p,p'-Dichlorodiphenyldichloroethylene (DDE)	HRL₉₃	Cancer	1	Cancer
50-29-3	p,p'-Dichlorodiphenyltrichloroethane (DDT)	HRL₉₃	Cancer	1	Cancer
75-34-3	1,1-Dichloroethane Toxicological Summary for 1,1-Dichloroethane (PDF)	RAA₁₆	Acute	ND	--
			Short-term	400	Nervous system
			Subchronic	400*	Nervous system
			Chronic	80	Nervous system
			Cancer	NA	--
107-06-2	1,2-Dichloroethane Toxicological Summary for 1,2-Dichloroethane (PDF)	HRL₁₃	Acute	ND	--
			Short-term	200	Liver system
			Subchronic	200*	Liver system
			Chronic	60	Kidney system; Liver system
			Cancer	1	Cancer
156-59-2	cis-1,2-Dichloroethene Toxicological Summary for cis-1,2-Dichloroethene (PDF)	HRL₀₉	Acute	ND	--
			Short-term	70	Blood system
			Subchronic	70*	Blood system
			Chronic	50	Blood system
			Cancer	NA	--
	cis-1,2-Dichloroethene Toxicological Summary for cis-1,2-Dichloroethene (PDF) Information sheet: cis-1,2-Dichloroethene and Drinking Water (PDF)	HBV₁₄	Acute	ND	--
			Short-term	20	Liver system
			Subchronic	10	Kidney system
			Chronic	6	Kidney system
			Cancer	NA	--
156-60-5	trans-1,2-Dichloroethene Toxicological Summary for trans-1,2-Dichloroethene (PDF)	HRL₁₃	Acute	ND	--
			Short-term	ND	--
			Subchronic	200	Immune system
			Chronic	40	Immune system
			Cancer	NA	--
75-35-4	1,1-Dichloroethylene (Vinylidene chloride) Toxicological Summary for 1,1-Dichloroethylene (Vinylidene chloride) (PDF)	HRL₁₁	Acute	ND	--
			Short-term	ND	--
			Subchronic	200	Liver system
			Chronic	200	Liver system
			Cancer	NA	--
75-43-4	Dichlorofluoromethane (DCFM) Toxicological Summary for Dichlorofluoromethane (PDF) Information sheet: Dichlorofluoromethane and Drinking Water (PDF)	RAA₁₅	Acute	ND	--
			Short-term	30	Immune system; Liver system; Developmental
			Subchronic	30*	Developmental; Liver system; Immune system; Male reproductive system
			Chronic	30*	Developmental; Liver system; Immune system; Male reproductive system
			Cancer	NA	--
75-09-2	Dichloromethane (Methylene chloride)	HRL_MCL	Chronic	5	see USEPA Organic Chemicals table
120-83-2	2,4-Dichlorophenol	HRL₉₃	Chronic	20	Immune system
94-75-7	2,4-Dichlorophenoxyacetic acid (2,4-D) Toxicological Summary for 2,4-Dichlorophenoxyacetic acid (PDF) Information Sheet: 2.4-D and Drinking Water (PDF)	HRL₉₃	Chronic	70	Blood system; Liver system; Kidney system
		HBV₁₆	Acute	ND	--
			Short-term	30	Adrenal, Developmental, Thyroid (E)
			Subchronic	30*	Adrenal, Developmental, Thyroid (E)
			Chronic	30*	Adrenal, Developmental, Thyroid (E)
			Cancer	ND	--
78-87-5	1,2-Dichloropropane	HRL₉₄	Cancer	5	Cancer
542-75-6	1,3-Dichloropropene	HRL₉₄	Cancer	2	Cancer
60-57-1	Dieldrin Toxicological Summary for Dieldrin (PDF)	HRL₀₉	Acute	0.2	Developmental
			Short-term	0.2	Developmental; Immune system; Nervous system
			Subchronic	0.2*	Developmental; Immune system; Nervous system
			Chronic	0.2	Liver system; Nervous system
			Cancer	0.006	Cancer
134-62-3	N,N-Diethyl-meta-toluamide (DEET) Toxicological Summary for N,N-Diethyl-meta-toluamide (DEET) (PDF) Information Sheet: DEET in Drinking Water (PDF)	HRL₁₃	Acute	ND	--
			Short-term	200	Developmental; Nervous system
			Subchronic	200*	Developmental; Nervous system
			Chronic	200*	Developmental; Nervous system
			Cancer	NA	--
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117-81-7	Di(2-ethylhexyl)phthalate (DEHP) Toxicological Summary for Di(2-ethylhexyl) phthalate (PDF) Information Sheet: Phthalates and Drinking Water (PDF)	HRL₁₅	Acute	20	Developmental (E); Male reproductive system (E)
			Short-term	20	Developmental (E); Male reproductive system (E)
			Subchronic	20*	Developmental (E); Male reproductive system (E)
			Chronic	20*	Developmental (E); Male reproductive system (E)
			Cancer	7	Cancer
84-66-2	Diethyl phthalate	HRL₉₃	Chronic	6,000	None
87674-68-8 163515-14-8	Dimethenamid & Dimethenamid-P Toxicological Summary for Dimethenamid & Dimethenamid-P (PDF) Information Sheet: Dimethenamid and Drinking Water (PDF) See also degradates: Dimethenamid ESA & Dimethenamid OXA (PDF)	HRL₁₅	Acute	ND	--
			Short-term	600	Developmental; Liver system; Nervous system; Female reproductive system
			Subchronic	600*	Developmental; Liver system; Nervous system; Female reproductive system
			Chronic	300	Liver system
			Cancer	NA	--
205939-58-8 not found	Dimethenamid ESA Dimethenamid OXA Toxicological Summary for Dimethenamid Degradates: ESA and OXA (PDF) Information Sheet: Dimethenamid and Drinking Water (PDF)	RAA₁₃	Acute	ND	--
			Short-term	600	Developmental; Liver system; Nervous system; Female reproductive system
			Subchronic	600	Developmental; Liver system
			Chronic	300	Liver system
			Cancer	NA	--
105-67-9	2,4-Dimethylphenol	HRL₉₃	Chronic	100	Blood system; Nervous system
131-11-3	Dimethylphthalate	HRL₉₄	Chronic	70,000	Kidney system
51-28-5	2,4-Dinitrophenol	HRL₉₄	Chronic	10	Eyes
123-91-1	1,4-Dioxane Toxicological Summary for 1,4-Dioxane (PDF) Information Sheet: 1,4-Dioxane in Drinking Water (PDF)	HRL₁₃	Acute	ND	--
			Short-term	ND	--
			Subchronic	300	Liver system; Kidney system; Respiratory system
			Chronic	100	Liver system; Kidney system; Respiratory system
			Cancer	1	Cancer
298-04-4	Disulfoton	HRL₉₄	Chronic	0.3	Nervous system
57-63-6	17α-Ethinylestradiol Toxicological Summary for 17α-Ethinylestradiol (PDF) Information Sheet: 17α-Ethinylestradiol and Mestranol and Drinking Water (PDF)	HBV₁₆	Acute	ND	--
			Short-term	0.0005	Developmental (E), Female Reproductive system (E), Male Reproductive system (E)
			Subchronic	0.0002	Developmental
			Chronic	0.0002**	Developmental
			Cancer	ND	--
100-41-4	Ethylbenzene Toxicological Summary for Ethylbenzene (PDF)	HRL₁₁	Acute	ND	--
			Short-term	50	Liver system; Kidney system
			Subchronic	50*	Liver system; Kidney system
			Chronic	50*	Liver system; Kidney system
			Cancer	NA	--
759-94-4	S-Ethyl-N,N-dipropylthiocarbamate (EPTC) Toxicological Summary for S-Ethyl-N,N-dipropythiocarbamate (PDF) Information Sheet: S-Ethyl-N,N-dipropythiocarbamate (EPTC) and Drinking Water (PDF)	HRL₉₃	Chronic	200	Cardiovascular system; Nervous system
		HBV₁₅	Acute	300	Nervous system
			Short-term	300	Developmental; Female reproductive system; Nervous system
			Subchronic	90	Cardiovascular system
			Chronic	40	Cardiovascular system
			Cancer	NA	--
60-29-7	Ethyl ether Toxicological Summary for Ethyl ether (PDF)	RAA₁₆	Acute	ND	--
			Short-term	ND	--
			Subchronic	1000	Liver system; Kidney system
			Chronic	200	Liver system; Kidney system
			Cancer	NA	--
107-21-1	Ethylene glycol Toxicological Summary for Ethylene glycol (PDF)	HRL₁₁	Acute	4,000	Developmental
			Short-term	4,000	Developmental
			Subchronic	2,000	Developmental; Kidney system
			Chronic	2,000	Developmental; Kidney system
			Cancer	NA	--
206-44-0	Fluoranthene Toxicological Summary for Fluoranthene (PDF) Information Sheet: Fluoranthene in Drinking Water (PDF)	HRL₉₃	Chronic	300	Liver system; Kidney system
		HBV₁₅	Acute	ND	--
			Short-term	ND	--
			Subchronic	200	Liver system; Kidney system
			Chronic	70	Liver system; Kidney system
			Cancer	N/A	see Guidance for Evaluating the Cancer Potency of PAH Mixtures (PDF)
86-73-7	Fluorene (9H-Fluorene)	HRL₉₃	Chronic	300	Blood system
50-00-0	Formaldehyde	HRL₉₄	Chronic	1,000	Gastrointestinal system
76-44-8	Heptachlor	HRL₉₃	Cancer	0.08	Cancer
1024-57-3	Heptachlor epoxide	HRL₉₃	Cancer	0.04	Cancer
118-74-1	Hexachlorobenzene	HRL₉₃	Cancer	0.2	Cancer
87-68-3	Hexachlorobutadiene	HRL₉₃	Chronic	1	Kidney system
110-54-3	Hexane (n-hexane)	HRL₉₄	Chronic	400	Nervous system
78-83-1	Isobutanol Toxicological Summary for Isobutanol (PDF) Information Sheet: Isobutanol and Drinking Water (PDF)	HBV₁₆	Acute	ND	--
			Short-term	ND	--
			Subchronic	700	Male reproductive system
			Chronic	300	Male reproductive system
			Cancer	NA	--
78-59-1	Isophorone	HRL₉₃	Chronic	100	Kidney system
330-55-2	Linuron	HRL₉₃	Chronic	1	Blood system
7439-96-5	Manganese Toxicological Summary for Manganese (PDF) Tiered Health Based Guidance for Water Information sheet: Manganese in Drinking Water (PDF)	HRL_93***	Chronic	100	Nervous system
		RAA₁₂	Infant	100	Nervous system
		RAA₁₂	Child/Adult	300	Nervous system
72-33-3	Mestranol Toxicological Summary for Mestranol (PDF) Information Sheet: 17α-Ethinylestradiol and Mestranol and Drinking Water (PDF)	RAA₁₆	Acute	ND	--
			Short-term	0.0007	Developmental (E), Female Reproductive system (E), Male Reproductive system (E)
			Subchronic	0.0002	Developmental
			Chronic	0.0002**	Developmental
			Cancer	ND	--
67-56-1	Methanol	HRL₉₄	Chronic	3,000	Liver system; Nervous system
94-74-6	2-Methyl-4-chlorophenoxyacetic acid (MCPA)	HRL₉₃	Chronic	3	Liver system; Kidney system
78-93-3	Methyl ethyl ketone (MEK, 2-butanone)	HRL₉₄	Chronic	4,000	Developmental
108-10-1	Methyl isobutyl ketone (MIBK)	HRL₉₄	Chronic	300	Liver system; Kidney system
1634-04-4	Methyl tert-butyl ether (MTBE) Toxicological Summary for Methyl tert-butyl ether (MTBE) (PDF) Information Sheet for Methyl tert-butyl ether (MTBE) and Drinking Water (PDF)	RAA₁₃	Acute	ND	--
			Short-term	700	Liver system; Nervous system; Kidney system
			Subchronic	700*	Liver system; Nervous system; Kidney system
			Chronic	700*	Liver system; Nervous system; Kidney system
			Cancer	60	Cancer
91-57-6	2-Methylnaphthalene Toxicological Summary for 2-Methylnaphthalene (PDF) Information Sheet: 2-Methylnaphthalene and Drinking Water (PDF)	RAA₁₃	Acute	ND	--
			Short-term	ND	--
			Subchronic	ND	--
			Chronic	8	Respiratory system
			Cancer	ND	--
95-48-7	2-Methylphenol (o-cresol)	HRL₉₃	Chronic	30	Nervous system
108-39-4	3-Methylphenol (m-cresol)	HRL₉₃	Chronic	30	Nervous system
106-44-5	4-Methylphenol (p-cresol)	HRL₉₄	Chronic	3	None
51218-45-2; 87392-12-9	Metolachlor and s-Metolachlor Toxicological Summary for Metolachlor and s-Metolachlor (PDF) See also degradates Metolachlor ESA Metolachlor OXA	HRL₁₁	Acute	400	Developmental
			Short-term	400	Developmental
			Subchronic	300	None
			Chronic	300**	None
			Cancer	NA	--
171118-09-5	Metolachlor ESA Toxicological Summary for Metolachlor ESA (PDF) (degradate of Metolachlor)	HRL₁₁	Acute	ND	--
			Short-term	ND	--
			Subchronic	4,000	Liver system
			Chronic	800	Liver system
			Cancer	NA	--
152019-73-3	Metolachlor OXA Toxicological Summary for Metolachlor OXA (PDF) (degradate of Metolachlor)	HRL₁₁	Acute	ND	--
			Short-term	3,000	None
			Subchronic	3,000*	None
			Chronic	800	None
			Cancer	NA	--
21087-64-9	Metribuzin Toxicological Summary for Metribuzin (PDF) See also degradates: Metribuzin DA, DK, and DADK (PDF)	HRL₁₃	Acute	30	Developmental; Nervous system
			Short-term	10	Thyroid (E)
			Subchronic	10*	Thyroid (E)
			Chronic	10*	Thyroid (E)
			Cancer	NA	--
35045-02-4; 56507-37-0; 52236-30-3	Metribuzin DA, DK, and DADK Toxicological Summary for Metribuzin Degradates DA, DK, and DADK (PDF) Information Sheet: Metribuzin Degradates in Drinking Water (PDF)	RAA₁₂	Acute	30	Developmental; Nervous system
			Short-term	10	Thyroid (E)
			Subchronic	10*	Thyroid (E)
			Chronic	10*	Thyroid (E)
			Cancer	NA	--
77238-39-2; 101043-37-2	Microcystin Toxicological Summary for Microcystin (PDF) Information Sheet: Microcystin-LR in Drinking Water (PDF)	HBV₁₅	Acute	NA	--
			Short-term	0.1	Liver System
			Subchronic	0.1*	Liver System
			Chronic	0.1	Liver System
			Cancer	NA	--
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91-20-3	Naphthalene Toxicological Summary for Naphthalene (PDF)	HRL₁₃	Acute	70	Nervous system
			Short-term	70	Nervous system
			Subchronic	70*	Nervous system
			Chronic	70	Nervous system, Spleen
			Cancer	NA	--
7440-02-0	Nickel, soluble salts	HRL₉₃	Chronic	100	None
14797-55-8	Nitrate (as nitrogen)	HRL_MCL	Acute	10,000	see USEPA Inorganic Chemicals table
86-30-6	N-Nitrosodiphenylamine	HRL₉₃	Cancer	70	Cancer
84852-15-3	Nonylphenol Toxicological Summary for p-Nonylphenol, branched isomers (PDF) Information Sheet: Nonylphenols and Drinking Water (PDF)	HBV₁₅	Acute	ND	--
			Short-term	100	Developmental; Female reproductive system
			Subchronic	40	Kidney system
			Chronic	20	Kidney system
			Cancer	NA	--
140-66-9	4-tert-Octylphenol Toxicological Summary for 4-tert-Octylphenol (PDF) Information Sheet: Octylphenol and Drinking Water (PDF)	HBV₁₅	Acute	ND	--
			Short-term	100	Developmental
			Subchronic	100*	Developmental
			Chronic	100*	Developmental
			Cancer	NA	--
87-86-5	Pentachlorophenol (PCP) Toxicological Summary for Pentachlorophenol (PCP) (PDF) Information Sheet: Pentachlorophenol and Drinking Water (PDF)	HRL₁₅	Acute	7	Developmental; Thyroid (E)
			Short-term	7	Developmental (E); Thyroid (E)
			Subchronic	7*	Developmental (E); Liver system; Immune system; Male Reproductive system; Thyroid (E)
			Chronic	7*	Developmental (E); Liver system; Immune system; Male Reproductive system; Thyroid (E)
			Cancer	0.3	Cancer
375-73-5	Perfluorobutane sulfonate (PFBS) Toxicological Summary for Perfluorobutane sulfonate (PFBS) (PDF)	HRL₁₁	Acute	ND	--
			Short-term	ND	--
			Subchronic	9	Blood system; Liver system;Kidney system
			Chronic	7	Blood system; Liver system;Kidney system
			Cancer	NA	--
375-22-4	Perfluorobutyrate (PFBA) Toxicological Summary for Perfluorobutyrate (PFBA) (PDF)	HRL₁₁	Acute	ND	--
			Short-term	7	Liver system; Thyroid (E)
			Subchronic	7*	Liver system; Thyroid (E)
			Chronic	7*	Liver system; Thyroid (E)
			Cancer	NA	--
355-46-4	Perfluorohexane sulfonate (PFHxS) Toxicological Summary for Perfluorohexane sulfonate (PFHxS) (PDF)	RAA₀₉	Acute	ND	--
			Short-term	ND	--
			Subchronic	ND	--
			Chronic	ND	--
			Cancer	NA	--
335-67-1; 335-66-0; 3825-26-1; 2395-00-8; 335-93-3; 335-95-5	Perfluorooctanoic Acid (PFOA) and Salts Toxicological Summary for Perfluorooctanoic Acid (PFOA) and Salts (PDF)	HRL₀₉	Acute	ND	--
			Short-term	ND	--
			Subchronic	ND	--
			Chronic	0.3	Development effects; Liver system; Immune system
			Cancer	NA	--
1763-23-1; 29081-56-9; 70225-14-8; 2795-39-3; 29457-72-5	Perfluorooctane Sulfonate (PFOS) and Salts Toxicological Summary for Perfluorooctane Sulfonate (PFOS) and Salts (PDF)	HRL₀₉	Acute	ND	--
			Short-term	ND	--
			Subchronic	ND	--
			Chronic	0.3	Developmental effects; Liver system; Thyroid (E)
			Cancer	NA	--
108-95-2	Phenol	HRL₉₃	Chronic	4,000	Developmental
1918-02-1	Picloram	HRL₉₃	Chronic	500	Liver system
1336-36-3	Polychlorinated biphenyls (PCBs)	HRL₉₄	Cancer	0.04	Cancer
1610-18-0	Prometon	HRL₉₃	Chronic	100	None
1918-16-7	Propachlor	HRL₉₃	Chronic	90	None
175013-18-0	Pyraclostrobin Toxicological Summary for Pyraclostrobin (PDF) Information Sheet: Pyraclostrobin in Drinking Water (PDF)	HBV₁₆	Acute	300	Developmental; Female Reproductive system
			Short-term	100	Developmental; Female Reproductive system; Gastrointestinal system; Spleen
			Subchronic	100	Developmental; Female Reproductive system; Gastrointestinal system; Blood system; Liver system; Immune system; Spleen
			Chronic	100**	Developmental; Female Reproductive system; Gastrointestinal system; Blood system; Liver system; Immune system; Spleen
			Cancer	NA	--
129-00-0	Pyrene Toxicological Summary for Pyrene (PDF) Information Sheet: Pyrene in Drinking Water (PDF)	HRL₉₃	Chronic	200	Kidney system
		HBV₁₅	Acute	ND	--
			Short-term	ND	--
			Subchronic	90	Kidney system
			Chronic	50	Kidney system
			Cancer	N/A	--
7782-49-2	Selenium	HRL₉₃	Chronic	30	None
7440-22-4	Silver	HRL₉₃	Chronic	30	None
122-34-9	Simazine	HRL_MCL	Chronic	4	see USEPA Organic Chemicals table
57-68-1	Sulfamethazine Toxicological Summary for Sulfamethazine (PDF) Information Sheet: Sulfonamide Antibiotics and Drinking Water (PDF)	HRL₁₅	Acute	ND	--
			Short-term	100	Thyroid
			Subchronic	100*	Thyroid
			Chronic	100*	Thyroid
			Cancer	NA	--
723-46-6	Sulfamethoxazole Toxicological Summary for Sulfamethoxazole (PDF) Information Sheet: Sulfonamide Antibiotics and Drinking Water (PDF)	RAA₁₃	Acute	ND	--
			Short-term	100	Thyroid
			Subchronic	100*	Thyroid
			Chronic	100*	Thyroid
			Cancer	NA	--
630-20-6	1,1,1,2-Tetrachloroethane	HRL₉₃	Chronic	70	Kidney system; Liver system
79-34-5	1,1,2,2-Tetrachloroethane	HRL₉₄	Cancer	2	Cancer
127-18-4	Tetrachloroethylene (PERC or PCE) Toxicological Summary for Tetrachloroethylene (PDF) Information Sheet: Tetrachloroethylene (PCE) and Drinking Water (PDF)	HRL_MCL	Chronic	5	see USEPA Organic Chemicals table
		HBV₁₄	Acute	ND	--
			Short-term	ND	--
			Subchronic	7	Nervous system
			Chronic	7**	Nervous system
			Cancer	4	Cancer
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109-99-9	Tetrahydrofuran Toxicological Summary for Tetrahydrofuran (PDF) Information Sheet: Tetrahydrofuran and Drinking Water (PDF)	HBV₁₆	Acute	ND	--
			Short-term	600	Developmental
			Subchronic	600*	Developmental
			Chronic	600*	Developmental
			Cancer	ND	--
7440-28-0	Thallium salts	HRL₉₄	Chronic	0.6	Liver system
153719-23-4	Thiamethoxam Toxicological Summary for Thiamethoxam (PDF) Information Sheet: Thiamethoxam and Drinking Water (PDF)	HBV₁₆	Acute	ND	--
			Short-term	400	Developmental, Female reproductive system, Liver system
			Subchronic	200	Male reproductive system
			Chronic	200**	Male reproductive system
			Cancer	NA	--
7440-31-5	Tin	HRL₉₄	Chronic	4,000	Liver system; Kidney system
108-88-3	Toluene Toxicological Summary for Toluene (PDF)	HRL₁₁	Acute	ND	--
			Short-term	200	Immune system; Nervous system
			Subchronic	200*	Immune system; Nervous system
			Chronic	200*	Immune system; Nervous system
			Cancer	NA	--
8001-35-2	Toxaphene	HRL₉₃	Cancer	0.3	Cancer
120-82-1	1,2,4-Trichlorobenzene Toxicological Summary for 1,2,4-Trichlorobenzene (PDF)	HRL₁₃	Acute	ND	--
			Short-term	100	Liver system; Adrenal (E); Blood system
			Subchronic	100*	Liver system; Adrenal (E); Blood system
			Chronic	100	Liver system; Adrenal (E); Kidney system
			Cancer	4	Cancer
108-70-3	1,3,5-Trichlorobenzene Toxicological Summary for 1,3,5-Trichlorobenzene (PDF)	RAA₁₂	Acute	ND	--
			Short-term	100	Liver system; Adrenal (E); Blood System
			Subchronic	100*	Liver system; Adrenal (E); Blood system
			Chronic	100	Liver system; Adrenal (E); Kidney system
			Cancer	4	Cancer
71-55-6	1,1,1-Trichloroethane Toxicological Summary for 1,1,1-Trichloroethane (PDF)	HRL₀₉	Acute	ND	--
			Short-term	ND	--
			Subchronic	20,000	Liver system; Male reproductive system
			Chronic	9,000	Liver system; Male reproductive system
			Cancer	NA	--
79-00-5	1,1,2-Trichloroethane	HRL₉₃	Chronic	3	Immune system
79-01-6	1,1,2-Trichloroethylene (TCE) Toxicological Summary for 1,1,2-Trichloroethylene (TCE) (PDF) Technical and Application Information Information Sheet: Trichloroethylene (TCE) and Drinking Water (PDF)	HRL₁₅	Acute	ND	--
			Short-term	0.4	Developmental, Immune
			Subchronic	0.4	Developmental, Immune
			Chronic	0.4**	Developmental, Immune
			Cancer	2	Cancer
75-69-4	Trichlorofluoromethane	HRL₉₃	Chronic	2,000	None
88-06-2	2,4,6-Trichlorophenol	HRL₉₃	Cancer	30	Cancer
93-76-5	2,4,5-Trichlorophenoxyacetic acid	HRL₉₃	Chronic	70	Developmental; Blood system
93-72-1	2-(2,4,5-Trichlorophenoxy) propionic acid	HRL_MCL	Chronic	50	see USEPA Organic Chemicals table
96-18-4	1,2,3-Trichloropropane Toxicological Summary for 1,2,3-Trichloropropane (PDF) Information Sheet: 1,2,3-TCP in Drinking Water (PDF)	HRL₁₃	Acute	7	Developmental
			Short-term	7	Developmental
			Subchronic	7*	Developmental
			Chronic	7*	Developmental
			Cancer	0.003	Cancer
76-13-1	1,1,2-Trichloro-1,2,2-trifluoroethane	HRL₉₃	Chronic	200,000	None
101-20-2	Triclocarban Toxicological Summary for Triclocarban (PDF) Information Sheet: Triclocarban and Drinking Water (PDF)	RAA₁₃	Acute	ND	--
			Short-term	ND	--
			Subchronic	ND	--
			Chronic	100	Blood system; Liver system; Male reproductive system; Kidney system
			Cancer	NA	--
3380-34-5	Triclosan Toxicological Summary for Triclosan (PDF) Information Sheet: Triclosan and Drinking Water (PDF)	HRL₁₅	Acute	ND	--
			Short-term	50	Developmental; Liver system; Thyroid (E); Female Reproductive system (E)
			Subchronic	50*	Developmental; Liver system; Thyroid (E); Female Reproductive system (E)
			Chronic	50*	Developmental; Liver system; Thyroid (E); Female Reproductive system (E)
			Cancer	NA	--
95-63-6	1,2,4-Trimethylbenzene Toxicological Summary for 1,2,4-Trimethylbenzene (PDF)	RAA₁₀	Acute	ND	--
			Short-term	100	Liver system
			Subchronic	100*	Liver system
			Chronic	100*	Liver system
			Cancer	NA	--
108-67-8	1,3,5-Trimethylbenzene Toxicological Summary for 1,3,5-Trimethylbenzene (PDF)	HRL₀₉	Acute	ND	--
			Short-term	100	Liver system
			Subchronic	100*	Liver system
			Chronic	100*	Liver system
			Cancer	NA	--
99-35-4	1,3,5-Trinitrobenzene	HRL₉₃	Chronic	0.3	None
115-96-8	Tris(2-chloroethyl)phosphate (TCEP) Toxicological Summary for Tris(2-chloroethyl)phosphate (PDF) Information Sheet: TCEP in Drinking Water (PDF)	HRL₁₃	Acute	ND	--
			Short-term	300	Developmental, Nervous system, Kidney system
			Subchronic	200	Kidney system
			Chronic	200**	Kidney system
			Cancer	5	Cancer
13674-87-8	Tris(1,3-dichloroisopropyl)phosphate (TDCPP) Toxicological Summary for Tris(1,3-dichloroisopropyl)phosphate (PDF) Information Sheet: TDCPP and Drinking Water (PDF)	HBV₁₃	Acute	ND	--
			Short-term	ND	--
			Subchronic	20	Liver system; kidney system
			Chronic	9	Kidney system; Male reproductive system
			Cancer	0.8	Cancer
7440-62-2	Vanadium	HRL₉₄	Chronic	50	None
93413-69-5, 99300-78-4	Venlafaxine Toxicological Summary for Venlafaxine (PDF) Information Sheet: Venlafaxine and Desvenlafaxine and Drinking Water (PDF)	HBV₁₅	Acute	ND	--
			Short-term	10	Developmental; Gastrointestinal system; Male reproductive system; Nervous system (E)
			Subchronic	10*	Developmental; Gastrointestinal system; Male reproductive system; Nervous system (E)
			Chronic	10*	Developmental; Gastrointestinal system; Male reproductive system; Nervous system (E)
			Cancer	NA	--
75-01-4	Vinyl Chloride Toxicological Summary for Vinyl Chloride (PDF) Information Sheet: Vinyl Chloride and Drinking Water (PDF)	HRL₀₉	Acute	ND	--
			Short-term	ND	--
			Subchronic	80	Liver system
			Chronic	10	Liver system
			Cancer	0.2	Cancer
1330-20-7	Xylenes Toxicological Summary for Xylenes (mixture of isomers, o, m, p) (PDF)	HRL₁₁	Acute	800	Nervous system
			Short-term	300	Nervous system
			Subchronic	300*	Kidney system; Nervous system
			Chronic	300*	Kidney system; Nervous system
			Cancer	NA	--
7440-66-6	Zinc	HRL₉₄	Chronic	2,000	None
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NA - Not Applicable
ND - Not derived due to insufficient information
None - Nonspecific effects that could not be attributed to an organ system
(E) = Endocrine mediated effect on the specified target organ

*Set at short-term value
**Set at subchronic value
***Dual guidance applies: See Dual Guidance for Drinking Water

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