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MLL2
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MLL2On this page:
Reviewed March 2011
What is the official name of the MLL2 gene?The official name of this gene is “myeloid/lymphoid or mixed-lineage leukemia 2.” MLL2 is the gene's official symbol. The MLL2 gene is also known by other names, listed below. Read more about gene names and symbols on the About page. What is the normal function of the MLL2 gene?The MLL2 gene provides instructions for making a protein that is found in many organs and tissues of the body. The MLL2 protein functions as a histone methyltransferase. Histone methyltransferases are enzymes that modify proteins called histones. Histones are structural proteins that attach (bind) to DNA and give chromosomes their shape. By adding a molecule called a methyl group to histones, histone methyltransferases control (regulate) the activity of certain genes, which is essential for normal development and function. The histone methyltransferase produced from the MLL2 gene appears to activate certain genes that are important for development. The MLL2 protein is also believed to act as a tumor suppressor, which means it normally helps prevent cells from growing and dividing in an uncontrolled way. Does the MLL2 gene share characteristics with other genes?The MLL2 gene belongs to a family of genes called chromatin-modifying enzymes (chromatin-modifying enzymes). A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook. How are changes in the MLL2 gene related to health conditions?
Where is the MLL2 gene located?Cytogenetic Location: 12q13.12 Molecular Location on chromosome 12: base pairs 49,412,757 to 49,449,106 The MLL2 gene is located on the long (q) arm of chromosome 12 at position 13.12. More precisely, the MLL2 gene is located from base pair 49,412,757 to base pair 49,449,106 on chromosome 12. See How do geneticists indicate the location of a gene? in the Handbook. Where can I find additional information about MLL2?You and your healthcare professional may find the following resources about MLL2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the MLL2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook. Where can I find general information about genes?The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful. What glossary definitions help with understanding MLL2?acids ; amino acid ; cancer ; cell ; chromosome ; colon ; DNA ; enzyme ; gene ; histone ; leukemia ; lineage ; lymphoid ; medulloblastoma ; methyl ; methylation ; methyltransferase ; molecule ; mutation ; myeloid ; protein ; somatic mutation ; syndrome ; tissue ; trinucleotide repeat ; tumor You may find definitions for these and many other terms in the Genetics Home Reference Glossary. See also Understanding Medical Terminology.
References (10 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook. |