Chromatin-modifying enzymes
Allis CD, Berger SL, Cote J, Dent S, Jenuwien T, Kouzarides T, Pillus L, Reinberg D, Shi Y, Shiekhattar R, Shilatifard A, Workman J, Zhang Y. New nomenclature for chromatin-modifying enzymes. Cell. 2007 Nov 16;131(4):633-6. PMID:18022353
| 1. K-demethylases |
| 2. K-acetyltransferases |
| 3. K-methyltransferases |
Click on the Approved Gene Symbol to retrieve the complete gene record
| Approved Symbol | Approved Name | Previous Symbols | Synonyms | Chromosome |
|---|---|---|---|---|
| KDM1A | lysine (K)-specific demethylase 1A | AOF2, KDM1 | KIAA0601, BHC110, LSD1 | 1p36.12 |
| KDM1B | lysine (K)-specific demethylase 1B | C6orf193, AOF1 | FLJ34109, FLJ33898, dJ298J15.2, bA204B7.3, FLJ43328, LSD2 | 6p22.3 |
| KDM2A | lysine (K)-specific demethylase 2A | FBXL11 | KIAA1004, FBL11, LILINA, DKFZP434M1735, FBL7, FLJ00115, CXXC8, JHDM1A | 11q13.1 |
| KDM2B | lysine (K)-specific demethylase 2B | FBXL10 | PCCX2, CXXC2, Fbl10, JHDM1B | 12q24.31 |
| KDM3A | lysine (K)-specific demethylase 3A | JMJD1, JMJD1A | TSGA, KIAA0742, JHMD2A | 2p11.2 |
| KDM3B | lysine (K)-specific demethylase 3B | C5orf7, JMJD1B | KIAA1082, NET22 | 5q31 |
| KDM4A | lysine (K)-specific demethylase 4A | JMJD2, JMJD2A | KIAA0677, JHDM3A, TDRD14A | 1p34.1 |
| KDM4B | lysine (K)-specific demethylase 4B | JMJD2B | KIAA0876, TDRD14B | 19p13.3 |
| KDM4C | lysine (K)-specific demethylase 4C | JMJD2C | GASC1, KIAA0780, TDRD14C | 9p24-p23 |
| KDM4D | lysine (K)-specific demethylase 4D | JMJD2D | FLJ10251 | 11q21 |
| KDM4E | lysine (K)-specific demethylase 4E | KDM4DL | JMJD2E | 11q21 |
| KDM5A | lysine (K)-specific demethylase 5A | RBBP2, JARID1A | 12p13.33 | |
| KDM5B | lysine (K)-specific demethylase 5B | JARID1B | RBBP2H1A, PLU-1, CT31 | 1q32.1 |
| KDM5C | lysine (K)-specific demethylase 5C | SMCX, JARID1C | DXS1272E, XE169 | Xp11.22-p11.21 |
| KDM5D | lysine (K)-specific demethylase 5D | HYA, HY, SMCY, JARID1D | KIAA0234 | Yq11 |
| KDM6A | lysine (K)-specific demethylase 6A | UTX | Xp11.2 | |
| KDM6B | lysine (K)-specific demethylase 6B | JMJD3 | KIAA0346 | 17p13.1 |
| JHDM1D | jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) | KIAA1718 | 7q34 | |
| PHF8 | PHD finger protein 8 | ZNF422, KIAA1111, JHDM1F | Xp11.22 | |
| PHF2 | PHD finger protein 2 | KIAA0662, JHDM1E, CENP-35 | 9q22 | |
| KDM8 | lysine (K)-specific demethylase 8 | JMJD5 | FLJ13798 | 16p12.1 |
| Approved Symbol | Approved Name | Previous Symbols | Synonyms | Chromosome |
|---|---|---|---|---|
| HAT1 | histone acetyltransferase 1 | KAT1 | 2q31.2-q33.1 | |
| KAT2A | K(lysine) acetyltransferase 2A | GCN5L2 | GCN5, PCAF-b | 17q12-q21 |
| KAT2B | K(lysine) acetyltransferase 2B | PCAF | P/CAF, GCN5, GCN5L | 3p24 |
| CREBBP | CREB binding protein | RSTS | RTS, CBP, KAT3A | 16p13.3 |
| EP300 | E1A binding protein p300 | p300, KAT3B | 22q13.2 | |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | TAF2A, BA2R, CCG1, CCGS, DYT3 | NSCL2, TAFII250, KAT4, DYT3/TAF1 | Xq13.1 |
| KAT5 | K(lysine) acetyltransferase 5 | HTATIP | TIP60, PLIP, cPLA2, HTATIP1, ESA1, ZC2HC5 | 11q13 |
| KAT6A | K(lysine) acetyltransferase 6A | ZNF220, RUNXBP2, MYST3 | MOZ, ZC2HC6A | 8p11 |
| KAT6B | K(lysine) acetyltransferase 6B | MYST4 | querkopf, qkf, Morf, MOZ2, ZC2HC6B | 10q22.2 |
| KAT7 | K(lysine) acetyltransferase 7 | MYST2 | HBOA, HBO1, ZC2HC7 | 17q21.32 |
| KAT8 | K(lysine) acetyltransferase 8 | MYST1 | MOF, FLJ14040, hMOF, ZC2HC8 | 16p11.1 |
| ELP3 | elongator acetyltransferase complex subunit 3 | FLJ10422, KAT9 | 8p21.1 | |
| GTF3C4 | general transcription factor IIIC, polypeptide 4, 90kDa | TFIIIC90, KAT12 | 9q34.3 | |
| NCOA1 | nuclear receptor coactivator 1 | SRC1, F-SRC-1, NCoA-1, KAT13A, RIP160, bHLHe74 | 2p23 | |
| NCOA3 | nuclear receptor coactivator 3 | RAC3, AIB1, ACTR, p/CIP, TRAM-1, CAGH16, TNRC16, KAT13B, bHLHe42, SRC-3, SRC3 | 20q12 | |
| NCOA2 | nuclear receptor coactivator 2 | TIF2, GRIP1, NCoA-2, KAT13C, bHLHe75 | 8q13.3 | |
| CLOCK | clock circadian regulator | KIAA0334, KAT13D, bHLHe8 | 4q12 |
| Approved Symbol | Approved Name | Previous Symbols | Synonyms | Chromosome |
|---|---|---|---|---|
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | SUV39H | KMT1A | Xp11.23 |
| SUV39H2 | suppressor of variegation 3-9 homolog 2 (Drosophila) | FLJ23414, KMT1B | 10p13 | |
| EHMT2 | euchromatic histone-lysine N-methyltransferase 2 | C6orf30, BAT8 | G9A, Em:AF134726.3, NG36/G9a, KMT1C | 6p21.3 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | Eu-HMTase1, FLJ12879, KIAA1876, bA188C12.1, KMT1D | 9 | |
| SETDB1 | SET domain, bifurcated 1 | KG1T, KIAA0067, ESET, KMT1E, TDRD21 | 1q21 | |
| SETDB2 | SET domain, bifurcated 2 | C13orf4 | CLLD8, CLLL8, KMT1F | 13q14 |
| MLL | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) | TRX1, HRX, ALL-1, HTRX1, CXXC7, MLL1A, KMT2A | 11q23 | |
| MLL3 | myeloid/lymphoid or mixed-lineage leukemia 3 | KIAA1506, HALR, KMT2C | 7q36 | |
| MLL2 | myeloid/lymphoid or mixed-lineage leukemia 2 | TNRC21 | ALR, MLL4, CAGL114, KMT2D | 12q13.12 |
| MLL5 | myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) | HDCMC04P, KMT2E | 7q22.1 | |
| SETD1A | SET domain containing 1A | KIAA0339, Set1, KMT2F | 16p11.2 | |
| SETD1B | SET domain containing 1B | KIAA1076, Set1B, KMT2G | 12q24.31 | |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | huASH1, ASH1, ASH1L1, KMT2H | 1q22 | |
| SETD2 | SET domain containing 2 | HYPB, HIF-1, KIAA1732, FLJ23184, KMT3A | 3p21.31 | |
| NSD1 | nuclear receptor binding SET domain protein 1 | STO | ARA267, FLJ22263, KMT3B | 5q35 |
| SMYD2 | SET and MYND domain containing 2 | HSKM-B, ZMYND14, KMT3C | 1q32.3 | |
| SMYD1 | SET and MYND domain containing 1 | BOP, ZMYND22, KMT3D | 2p11.1 | |
| SMYD3 | SET and MYND domain containing 3 | ZNFN3A1, ZMYND1 | KMT3E | 1q44 |
| DOT1L | DOT1-like, histone H3 methyltransferase (S. cerevisiae) | KIAA1814, DOT1, KMT4 | 19p13.3 | |
| SETD8 | SET domain containing (lysine methyltransferase) 8 | SET8, SET07, PR-Set7, KMT5A | 12q24.31 | |
| SUV420H1 | suppressor of variegation 4-20 homolog 1 (Drosophila) | CGI-85, KMT5B | 11q13.2 | |
| SUV420H2 | suppressor of variegation 4-20 homolog 2 (Drosophila) | MGC2705, KMT5C | 19q13.42 | |
| EZH2 | enhancer of zeste homolog 2 (Drosophila) | EZH1, ENX-1, KMT6, KMT6A | 7q35-q36 | |
| EZH1 | enhancer of zeste homolog 1 (Drosophila) | KIAA0388, KMT6B | 17q21.1-q21.3 | |
| SETD7 | SET domain containing (lysine methyltransferase) 7 | KIAA1717, SET7, SET7/9, Set9, KMT7 | 4q31.1 | |
| PRDM2 | PR domain containing 2, with ZNF domain | RIZ, RIZ1, RIZ2, KMT8, MTB-ZF, HUMHOXY1 | 1p36 |
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