All Clinical Trial Listings
Please click the links below to go to each Clinical Trial Listing on this page:
Protocol Number | Title | Study Status | PI | Website | Section | |
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Pilot | ||||||
07C0086 | Pilot Study of Educational Interventions in Pediatric Hematopoietic Stem Cell Donors to Increase Knowledge of Donation and Transplantation Procedures | Currently Accruing |
Wiener, Lori |
Psychosocial Hematopoietic Stem Cell Transplantation GVHD |
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07C0206 | A Pilot Study of Tumor Vaccination and RHIL-7 Following Standard Multimodality Therapy in Patients with High Risk Pediatric Solid Tumors | Not Currently Accruing |
Mackall, Crystal |
Link |
Solid Tumors |
|
08C0051 | A Pilot Trial of WT1 Peptide-Loaded Allogeneic Dendritic Cell Vaccine and Donor Lymphocyte Infusion for WT1-Expressing Hematologic Malignancies | Currently Accruing |
Wayne, Alan |
Link |
Hematologic Diseases |
|
11C0113 | A Pilot Study of Genetically Engineered NY-ESO-1 Specific (c259) T cells in HLA-A2+ Patients with Synovial Sarcoma | Currently Accruing |
Mackall, Crystal |
Link |
Solid Tumors |
|
Phase 1 | ||||||
08C0007 | A Phase I Study of Ipilimumab (Anti-CTLA4) in Children, Adolescents, and Young Adults with Treatment Refractory Cancer | Currently Accruing |
Melinda, Merchant |
Link |
Solid Tumors Pharmacology and Experimental Therapeutics |
|
08C0123 | A Phase 1, Multi-Center, Dose Escalation Study of CAT-8015 in Children, Adolescents, and Young Adults with Refractory CD22+ Acute Lymphoblastic Leukemia (ALL) or Non-Hodgkin's Lymphoma (NHL) | Not Currently Accruing |
Wayne, Alan |
Link |
Hematologic Diseases Pharmacology and Experimental Therapeutics |
|
09C0243 | A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-ribose)Polymerase and Temozolomide in Children with Recurrent/Refractory CNS Tumors | Currently Accruing |
Warren, Kathy |
Link |
Neuro-Oncology Pharmacology and Experimental Therapeutics |
|
10C0219 | A Phase I Trial of Lenalidomide and Radiotherapy in Children with Diffuse Intrinsic Pontine Gliomas and High-grade Gliomas | Currently Accruing |
Warren, Kathy |
Link |
Neuro-Oncology |
|
10C0220 | Phase I Trial to Evaluate the Safety, Activity and Pharmacokinetics of Marqibo® (Vincristine Sulfate Liposomes Injection) in Children and Adolescents with Refractory Cancer | Currently Accruing |
Wayne, Alan |
Link |
Solid Tumors Neuro-Oncology Hematologic Diseases |
|
11C0047 | Phase I trial and pharmacokinetic study of the oral platinum analog satraplatin in children and young adults with refractory solid tumors including brain tumors | Currently Accruing |
Widemann, Brigitte |
Link |
Solid Tumors Neuro-Oncology Pharmacology and Experimental Therapeutics |
|
09C0024 | A Phase I Study of Merck Human Papilloma Virus (HPV) RecombinantVaccine in HIV-Infected and HIV-Negative Pre-Adolescents, Adolescents, and Young Adults | Not Currently Accruing |
Wood, Lauren Wiener, Lori |
Psychosocial |
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11C0073 | A Phase I Study of NK Cell Infusion Following Allogeneic Peripheral Blood Stem Cell Transplantation from Related or Matched Unrelated Donors in Pediatric Patients with Solid Tumors and Leukemias | Currently Accruing |
Baird, Kristin |
Link |
Hematopoietic Stem Cell Transplantation Solid Tumors Hematologic Diseases |
|
11C0161 | A Phase 1 Study of the Mitogen Activated Protein Kinase Kinase (MEK) 1 Inhibitor AZD6244 Hydrogen Sulfate (Selumetinib Sulfate) in Children with Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN) | Currently Accruing |
Widemann, Brigitte |
Link |
Pharmacology and Experimental Therapeutics Neurofibromatosis |
|
11C0053 | Phase I Study of Temsirolimus in Combination With Irinotecan and Temozolomide in Children, Adolescents, and Young Adults With Relapsed or Refractory Solid Tumors | Currently Accruing |
Widemann, Brigitte |
Link |
Pharmacology and Experimental Therapeutics Solid Tumors |
|
11C0191 | Phase 1 and Pharmacokinetic Study of AZD6244 for Recurrent or Refractory Pediatric Low Grade Glioma | Currently Accruing |
Warren, Kathy |
Link |
Neuro-Oncology |
|
12C0112 | Phase I Study of T Cells Expressing an Anti-CD19 Chimeric Receptor in Children and Young Adults with B Cell Malignancies | Currently Accruing |
Wayne, Alan |
Link |
Hematologic Diseases |
|
12C0208 | Phase 1 Dose Escalation Study of Sorafenib and Irinotecan Combination Therapy in Pediatric Patients with Relapsed or Refractory Solid Tumors | Currently Accruing |
Widemann, Brigitte |
Pharmacology and Experimental Therapeutics Solid Tumors |
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Phase 1 & 2 | ||||||
07C0189 | Phase I/II Trial of Vandetanib (ZD6474, ZACTIMA) in Children and Adolescents with Hereditary Medullary Thyroid Carcinoma | Currently Accruing |
Widemann, Brigitte |
Link |
Medullary Thyroid Carcinoma Pharmacology and Experimental Therapeutics |
|
10C0178 | A Phase 1/2 Study of PF-02341066, An Oral Small Molecule Inhibitor of Anaplastic Lymphoma Kinase (ALK) and C-Met, in Children with Relapsed/Refractory Solid Tumors and Anaplastic Large Cell Lymphoma | Currently Accruing |
Widemann, Brigitte |
Link |
Solid Tumors Hematologic Diseases Pharmacology and Experimental Therapeutics |
|
12C0135 | Phase I/II Trial of Mithramycin in Children and Adults with Refractory Extracranial Solid Tumors (Phase I) or Ewing Sarcoma and EWS-FLI1 Fusion Transcript (Phase II) | Currently Accruing |
Widemann, Brigitte |
Link |
Solid Tumors Pharmacology and Experimental Therapeutics |
|
12C0213 | PBTC-033 A Phase I/II Study of ABT-888, an Oral Poly (ADP-ribose) Polymerase Inhibitor, and Concurrent Radiation Therapy, Followed by ABT-888 and Temozolomide, in Children with Newly Diagnosed Diffuse Pontine Glioma (DIPG) | Open to Accrual |
Warren, Kathy |
Neuro-Oncology |
||
Phase 2 | ||||||
06C0043 | Phase II Trial of Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated High Grade Malignant Peripheral Nerve Sheath Tumors | Currently Accruing |
Widemann, Brigitte |
Link |
Neurofibromatosis Pharmacology and Experimental Therapeutics |
|
08C0096 | A Phase II Study of the mTOR Inhibitor Sirolimus in Neurofibromatosis Type 1 Related Plexiform Neurofibromas | Currently Accruing |
Widemann, Brigitte |
Link |
Neurofibromatosis |
|
08C0130 | A Phase II Trial of Peginterferon alfa-2b (Pegintron) for Neurofibromatosis Type 1 Related Unresectable, Symptomatic or Life-Threatening Plexiform Neurofibromas | Currently Accruing |
Widemann, Brigitte |
Link |
Neurofibromatosis |
|
09C0104 | A Randomized, Double-Blinded, Placebo-Controlled, Multi-Institutional, Phase II.5 Study of AZD0530, a Selective Src Kinase Inhibitor, In Patients with Recurrent Osteosarcoma Localized to the Lung | Currently Accruing |
Baird, Kristin |
Link |
Sarcomas |
|
08C0097 | Multi-institutional Prospective Phase II Study of Montelukast for the Treatment of Bronchiolitis Obliterans following Allogeneic or Autologous Stem Cell Transplantation in Children and Adults | Currently Accruing |
Gress, Ronald Baird, Kristin Wayne, Alan |
Link |
GVHD |
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12C0058 | A Phase II Study of Everolimus (RAD001) for Children with Neurofibromatosis Type-1 and Chemotherapy-Refractory Radiographic Progressive Low-Grade Gliomas | Currently Accruing |
Warren, Kathy |
Link |
Neuro-Oncology Neurofibromatosis |
|
12C0098 | A Phase II Study of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib (IND# 69896) in Children and Young Adults with Relapsed / Refractory Rhabdomyosarcoma, Wilms Tumor, Hepatocellular Carcinoma, and Papillary Thyroid Carcinoma | Currently Accruing |
Widemann, Brigitte |
Link |
Pharmacology and Experimental Therapeutics Solid Tumors |
|
12C0148 | SARC016: Phase II Study of the mTOR Inhibitor Everolimus in Combination With Bevacizumab in Patients With Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors | Currently Accruing |
Widemann, Brigitte |
Link |
Pharmacology and Experimental Therapeutics Neurofibromatosis |
|
12C0136 | A Phase II Randomized Trial of Lenalidomide in Pediatric Patients With Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytomas and Optic Pathway Gliomas | Currently Accruing |
Warren, Kathy |
Link |
Neuro-Oncology |
|
Natural History | ||||||
04C0275 | Targeted Oncolytic Virotherapy and Natural History Study of KSHV-Associated Multicentric Castleman's Disease with Laboratory and Clinical Correlates of Disease Activity | Currently Accruing |
Yarchoan, Robert |
Link | ||
08C0079 | Natural History Study and Longitudinal Assessment of Children, Adolescents, and Adults with Neurofibromatosis Type 1 | Currently Accruing |
Widemann, Brigitte |
Link |
Neurofibromatosis |
|
04C0281 | Natural History Study of Clinical and Biological Factors Determining Outcomes in Chronic Graft-Versus-Host Disease | Currently Accruing |
Pavletic, Stephen Baird, Kristin Wayne, Alan |
Link |
GVHD |
|
12C0178 | Longitudinal Assessment and Natural History Study of Children and Young Adults With Medullary Thyroid Carcinoma | Currently Accruing |
Widemann, Brigitte |
Link |
Medullary Thyroid Carcinoma Pharmacology and Experimental Therapeutics |
|
Screening | ||||||
01C0157 | Eligibility Screening and Tissue Procurement for the National Cancer Institute (NCI), Pediatric Oncology Branch (POB) Clinical Research Protocols | Currently Accruing |
Mackall, Crystal |
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Other | ||||||
01C0030 | Short-Course EPOCH - Rituximab in Untreated CD-20+ HIV-Associated Lymphomas | Currently Accruing |
Wilson, Wyndham |
Link |
Hematologic Diseases |
|
02C0313 | Cancer Risk in Xeroderma Pigmentosum Heterozygotes | Currently Accruing |
Kraemer, Kenneth |
Link | ||
03C0278 | A Comparative Study of Pediatric CNS Tumor Activity as Assessed by 18F-FDG PET Imaging and Proton Magnetic Resonance Spectroscopic Imaging (1H-MRSI) | Open to Accrual |
Warren, Kathy |
Link |
Neuro-Oncology |
|
04C0102 | Hematologic Malignancy Biology Study | Currently Accruing |
Wayne, Alan |
Link |
Hematologic Diseases |
|
06C0219 | An Exploratory Study of Biologic and Pathophysiologic Effects of Radiation Therapy in Pediatric Patients with Central Nervous System Tumors | Currently Accruing |
Warren, Kathy |
Link |
Neuro-Oncology |
|
07C0110 | Analysis of Stored Data Collected from Individuals Administered Neurobehavioral Assessments on IRB-approved Protocols | Currently Accruing |
Hazra, Rohan |
Link | ||
10C0019 | Development and validation of a symptom scale for children with chronic graft-versus-host disease | Currently Accruing |
Wiener, Lori |
Link |
Psychosocial Hematologic Diseases GVHD |
|
83C0022 | Psychological Benefits of a Normalized Camping Experience for Children with Cancer | Currently Accruing |
Chanock, Stephen |
Link | ||
98C0037 | Treatment of Children with Cancer | Currently Accruing |
Mackall, Crystal |
Link | ||
10C0086 | Comprehensive Omics Analysis of Pediatric Solid Tumors and Establishment of a Repository for Related Biological Studies | Currently Accruing |
Javed, Khan |
Link |
Solid Tumors |
|
10C0111 | Protocol for the Enrollment on the Official COG Registry, The Childhood Cancer Research-Network (CCRN) Children's Oncology Group | Open to Accrual |
Mackall, Crystal |
Link | ||
11C0132 | Understanding the Psychosocial Needs of Parents Who Have Lost a Child to Cancer | Currently Accruing |
Wiener, Lori |
Link |
Psychosocial |
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11CC0063 | Evaluating Supportive Care for Children with Cancer: A Multi-Institutional Survey Study of Pediatric Oncology Patients and Parents | Currently Accruing |
David, Wendler Deena, Levine |
Link |
Psychosocial |
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09M0022 | The Use of a Distress Thermometer in a Pediatric Research Setting: An Exploratory | Currently Accruing |
Pao, Maryland Wiener, Lori |
Link |
Psychosocial |
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09M0194 | Characterizing Lone Parenting: A Multi-Institutional Pilot Study of the Perceptions of Support and Perceived Stress of Lone Parents of Children with Cancer | Currently Accruing |
Pao, Maryland Wiener, Lori |
Link |
Psychosocial |
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OHSR5018 | The Roles and Training Needs of Pediatric Psycho-Oncology Providers | Currently Accruing |
Wiener, Lori |
Psychosocial |
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OHSR4800 | ShopTalk: An Examination of the Utility and Feasibility of a Therapeutic Board Game | Currently Accruing |
Wiener, Lori |
Psychosocial |
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OHSR4799 | Psychosocial and Education Intervention for Pediatric Patients on Medical Isolation | Currently Accruing |
Wiener, Lori |
Psychosocial |
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11C0159 | A Feasibility Trial using Molecular-Guided Therapy for the Treatment of Patients with Refractory or Recurrent Neuroblastoma | Currently Accruing |
Javed, Khan |
Link |
Solid Tumors |
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12C0155 | Acceptance and Commitment Therapy for Adolescents and Adults With Neurofibromatosis Type 1 and Chronic Pain: A Pilot Study | Currently Accruing |
Peron, Staci |
Link |
Psychosocial Neurofibromatosis |
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12C0160 | Validation of the English Version of the Pain Interference Index and the Pain Rating Scale in Children, Adolescents, and Young Adults With Chronic Illness and Their Parents | Currently Accruing |
Peron, Staci |
Link |
Psychosocial Neurofibromatosis Solid Tumors Hematologic Diseases |
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12C0206 | Understanding the Perceived Influence of Childhood Cancer on the Parents' Marital/partner Relationship: A Descriptive Study | Currently Accruing |
Wiener, Lori |
Psychosocial |