National Toxicology Program

CASRN: 335-67-1

Formula: C8-H-F15-O2

Synonyms/Common Names:

• C8 CARBOXYLIC ACID
• PENTADECAFLUOROOCTANOIC ACID (9CI)

Known Uses:

Dielectric liquid material proposed for use to replace PCBs in transformers

Nomination Background

Short-Term Toxicity

• 28 days (Gavage)  (C91070B)  On Test 
  • Rats: Harlan Sprague-Dawley
  • Dose: Males: 0, 0.625, 1.25, 2.5, 5, or 10 mg/kg; Females: 0, 6.25, 12.5, 25, 50, or 100 mg/kg.
• 4 days (Gavage) Selected (C91070)  
  • Rats: Harlan Sprague-Dawley
  • Dose: Male mice: 1 ml/mg.

Long-Term Carcinogenicity

• 2 years (Dosed-Feed)  (C20614B)  Histopath in progress 
  • Rats: Harlan Sprague-Dawley
  • Dose: MR: 0, 20, 40, 80, 300/0, 300/20, 300/40, or 300/80 ppm.
• 2-YEAR (Dosed-Feed)  (C20614)  Histopath in progress 
  • Rats: Harlan Sprague-Dawley
  • Dose: FR: 0, 300, OR 1000 PPM; MR: 0, 150, OR 300; 60/SEX.

Modified One-Generation

• Dose Range Finding Selected (MOG91070)  
  • Dose Range finding
  • Rats: Harlan Sprague-Dawley; Mice: CD-1 Reg.[Crl:CD1(ICR)]

Special Studies

• Cell Proliferation (Gavage)  (S0174)  Completed 
  • Citation: CUNNINGHAM, ET.AL., REGULATION OF PERFLUOROOCTANOIC ACID-INDUCED PEROXISOMAL ENZYME ACTIVITIES & HEPATOCELLULAR GROWTH BY ADRENAL HORMONES, HEPATOLOGY 15:316-322,1992.
  • Male Rats: Sprague Dawley
  • Dose: 150 MG/KG.

Genetic Toxicology

• Micronucleus  (G91070)  Completed 
  • Rats
• Salmonella  (A98283)  Completed 
  •  Equivocal 

Organ Systems Toxicity

• 6 GD to PND 21 Conventional Teratology (Gavage) Selected (R91070)  
  • Rats: Sprague Dawley