National Toxicology Program

CASRN: 13674-84-5

Formula: C9-H18-Cl3-O4-P

Synonyms/Common Names:

• 2-PROPANOL, 1-CHLORO-, PHOSPHATE (3:1) (9CI)
• TCPP

Secondary:

• TRISCHLOROMX - Tris(chloropropyl)phosphate, mixture

Known Uses:

Flame retardant; commercially used mixture

Short-Term Toxicity

• 90 days (Dosed-Feed)  (C20712)  Completed 
  • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
  • Dose: R: 0, 2500, 5000, 10000, 20000, or 40000 ppm (perinatal only); M: 0, 1250, 2500, 5000, 10000, or 20000 ppm; 10/sex/species/dose.

Long-Term Carcinogenicity

• 2 years (Dosed-Feed)  (C20712)  On Test 
  • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
  • Dose: R: 0, 2500, 5000, 10,000 or 20,000 ppm; MM: 0, 1250, 2500, or 5000 ppm; FM: 0, 2500, 5000 or 10,000 ppm; 50/sex/species/group.

Special Studies

• 14 days Palatability (Dosed-Feed)  (K20263B)  Completed 
  • Male and Female Rats: Wistar Han; Male and Female Mice: B6C3F1
  • Dose: 0, 30,000, 40,000, and 50,000 ug/g/day.
• Toxicokinetic Study (Gavage; Intravenous) Selected (K20263)  
  • Male and Female Mice: B6C3F1/N
  • Dose: 1250, 2500, 5000 ppm. 2500, 5000, 10000 ppm. 2500, 5000, 10000, 20000 ppm. PTKS11357 [oral]: 100 mg/kg bwt. TKS: 50, 100, 500 mg/kg. PTKS11358 [IV]: 4 mg/kg bwt. TKS: 4.0 mg/kg.
• Toxicokinetic Study (Gavage; Intravenous) Selected (K20263)  
  • Male and Female Rats: Harlan Sprague-Dawley
  • Dose: 1250, 2500, 5000 ppm. 2500, 5000, 10000 ppm. 2500, 5000, 10000, 20000 ppm. PTKS11357 [oral]: 100 mg/kg bwt. TKS: 50, 100, 500 mg/kg. PTKS11358 [IV]: 4 mg/kg bwt. TKS: 4.0 mg/kg.
• Toxicokinetic Study (Dosed-Feed) Selected (K20263)  
  • Male and Female Rats: Harlan Sprague-Dawley; Female Mice: B6C3F1; Male Mice: B6C3F1
  • Dose: 1250, 2500, 5000 ppm. 2500, 5000, 10000 ppm. 2500, 5000, 10000, 20000 ppm. PTKS11357 [oral]: 100 mg/kg bwt. TKS: 50, 100, 500 mg/kg. PTKS11358 [IV]: 4 mg/kg bwt. TKS: 4.0 mg/kg.

Genetic Toxicology

• Micronucleus  (G20263B)  Completed 
  • Mice: B6C3F1
  • Male Positive 
  • Female Negative 
• Micronucleus  (G20263)  Completed 
  • Rats: Harlan Sprague-Dawley
  • Male Negative 
  • Female Negative 
• Salmonella  (815918)  Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  •  Negative 

Organ Systems Toxicity

• GD 6 to GD 20 Developmental Toxicity (Gavage)  (R20263B)  Completed 
  • Female Rats: Harlan Sprague-Dawley
  • Dose: 0, 162.5, 325, or 650 mg/kg/day.
• ~ 15 days Teratology Pilot Studies (Gavage)  (R20263)  Completed 
  • Female Rats: Harlan Sprague-Dawley
  • Dose: 0, 300, 650, or 1,000 mg/kg/day.