The Office of Science Technology Policy (OSTP) and  Office of Management and Budget September 24, 2007 Federal Register Notice (text) (PDF) on Agency Recognition of Multiple Principal Investigators on Federally Funded Research Projects culminated the two-year efforts of Federal research agencies, under the auspices of the Research Business Models Subcommittee of the OSTP, to implement policies and procedures to formally allow more than one Principal Investigator (PI) on individual research awards. Information on the implementation strategies of Federal research agencies can be found at: http://rbm.nih.gov/toolkit.htm. 

The multi-PI option presents an important opportunity for investigators seeking support for projects or activities that require a team science approach. This option is targeted specifically to those projects that do not fit the single-PI model, and therefore is intended to supplement and not replace the traditional single PI model. The overarching goal is to maximize the potential of team science efforts in order to be responsive to the challenges and opportunities of the 21st century.

• Overview 
• Introduction
• Features of the Multiple-PI Model
• Features that NIH is Assessing for Potential Development in the Future
• Availability of the Multiple PI Model
• Decision to Use the Multiple PI Model
•  Frequently Asked Questions
•  Frequently Asked Questions for NIH SBIR/STTR Applications
• Examples of Project Leadership Plans for Multiple PI Grant Applications, April 26, 2006 (PDF - 21 KB)
• Multiple Principal Investigator Guidance to Reviewers, January 4, 2007 (MS Word - 27 KB)

• Establishment of Multi-PI Awards for the Support of Team Science Projects, NOT-OD-06-036, February 7, 2006
• Multi-PI Implementation Update, NOT-OD-06-069, May 11, 2006
• Office of Science and Technology Policy Concerning the Treatment of Principal Investigator, September 24, 2007 (PDF - 68 KB)

• Office of Science and Technology Policy, Executive Office of the President: Request for Information Related to Research Grants (PDF - 68 KB)
• Office of the Director, NIH: Request for Information on the Plan to Recognize Multiple PIs on NIH Grants

• General (MS Word - 392 KB)
• Allocation of Funds to Individual PIs (MS Word - 226 KB)
• Impact of Multiple-PI Projects in NIH Departmental Ranking Tables (MS Word - 93 KB)
• Use of Linked Awards when PIs are Located at Individual Institutions (MS Word - 266 KB)
• Assessment of the NIH Multi-PI Pilot:, June 14, 2007 (MS Word - 87 KB) - Perceptions of Investigators who Submitted an Application in Response to NIDDK RFA DK-05-014, “The Obese and Diabetic Intrauterine Environment: Long-term Metabolic or Cardiovascular Consequences in the Offspring”
• Assessment of Multi-Principal Investigator (MPI) pilot: Summary of post-review debriefing teleconferences, August-November 2006 (MS Word - 89 KB)

• Implementation Plans and Status Report, April 11, 2006 (PowerPoint - 149 KB)
• Report on Responses from the RFI (PowerPoint - 357 KB)
• Standard Review Criteria Modifications (in BOLD), January 4, 2007 (MS Word - 31 KB)
• Multi PI Comment Form (PDF - 32 KB)

• Please send email to multi_PI@mail.nih.gov.

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