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A Research Network of the Division of Cancer Prevention

CCOP - Community Clinical Oncology Program

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Dissemination in the Community

The CCOP program was designed nearly 30 years ago to engage community physicians in NCI clinical trials to facilitate the incorporation of research results into clinical practice. While the CCOP network participated in only cancer treatment clinical trials early in its existence, the next step was to innovative cancer prevention and control strategies.

The network has had a history of successful dissemination of research results into community medical practice for prevention, treatment and control. The network mechanism helps active collaboration between academic investigators and community oncologists. Academic investigators in the CCOP Research Bases bring the science forward in developing the clinical trials. Community-based physicians at the CCOP and MB-CCOP sites can observe and report real time clinical input as they implement the studies with their patients. When the completed trials report successful results, the community investigators rapidly adopt the findings, which benefit subsequent patients.

Cancer has been called a genomic disease because of its complexity, heterogeneity, and involvement of multiple genes and environmental factors. As cancer research increasingly involves the understanding and use of genomic information, the Research Bases will incorporate this emerging science into novel trial designs for cancer treatment, prevention and control research, and CCOPs and MB-CCOPs will maximize community resources to conduct more complex clinical trials.

Selected Publications

  • Carpenter WR, Weiner BJ, Kaluzny AD, et al. The effects of managed care and competition on community-based clinical research. Med Care. 2006 Jul;44(7):671-9.
    [ PubMed Abstract ]
  • Helfrich CD, Weiner BJ, McKinney MM, Minasian L. Determinants of implementation effectiveness: adapting a framework for complex innovations. Med Care Res Rev. 2007 Jun;64(3):279-303.
    [ PubMed Abstract ]
  • Klabunde CN, Kaluzny AD. Accrual to the Breast Cancer Prevention Trial by participating Community Clinical Oncology Programs: a panel data analysis. Breast Cancer Res Treat. 1995. July;35(1):43-50.
    [ PubMed Abstract ]
  • Klabunde C, Kaluzny A, Ford L. Community Clinical Oncology Program participation in the Breast Cancer Prevention Trial: factors affecting accrual. Cancer Epidemiol Biomarkers Prev. 1995 Oct-Nov;4(7):783-9.
    [ PubMed Abstract ]
  • Laliberte L, Fennell ML, Papandonatos G. The relationship of membership in research networks to compliance with treatment guidelines for early-stage breast cancer. Med Care. 2005 May;43(5):471-9.
    [ PubMed Abstract ]
  • McKinney MM, Barnsley JM, Kaluzny AD. Organizing for Cancer Control. The diffusion of a dynamic innovation in a community cancer network. Int J Technol Assess Health Care. 1992 Spring;8(2):268-88.
    [ PubMed Abstract ]
  • McKinney MM, Morrissey JP, Kaluzny AD. Interorganizational exchanges as performance markers in a community cancer network. Health Serv Res. 1993 Oct;28(4):459-78.
    [ PubMed Abstract ]
  • McKinney MM, Weiner BJ, Carpenter WR. Building community capacity to participate in cancer prevention research. Cancer Control. 2006 Oct;13(4):295-302. No abstract available.
    [ PubMed Abstract ]
  • Minasian LM, Carpenter WR, Weiner BJ, et al. Translating research into evidence-based practice: the National Cancer Institute Community Clinical Oncology Program. Cancer. 2010 Oct 1;116(19):4440-9. [Epub ahead of print]
    [ PubMed Abstract ]
  • Warnecke RB, Johnson TP, Kaluzny AD, Ford LG. The Community Clinical Oncology Program: its effect on clinical practice. Jt Comm J Qual Improv. 1995 July;21(7):336-9.
    [ PubMed Abstract ]
  • Weiner BJ, McKinney MM, Carpenter WR. Adapting clinical trials networks to promote cancer prevention and control research. Cancer. 2006 Jan 1;106(1):180-7.
    [ PubMed Abstract ]

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