Small Molecule Chemical Probe Development
The National Center of Advancing Translational Sciences (NCATS) is currently seeking a highly motivated Ph.D. scientist to join our efforts towards the development of small molecule chemical probes. The NCATS is an interdisciplinary Institute within NIH and a member of the Molecular Libraries Probe Production Center Network. NCATS uses state-of-the-art, high throughput technologies to identify novel disease targets and develop chemical probes for the exploration of protein, cellular function and target validation. The interdisciplinary nature of NCATS includes chemists, biologists, biochemists, computer scientists and automation engineers.
The successful candidate should possess a Ph.D. in Cellular Biology, Pharmacology, or related disciplines, with less than 5 years of post-graduation experience. He/she should have publication record in at least one disease area such as cancer biology, immunology, diabetes, or other rare diseases. He/she must have experience on developing image based cellular assays including associated image analysis using confocal and non-confocal microscopy. The candidate must be interested in both hands-on, data driven experimental approaches, as well as having a basic ability to use bioinformatics tools for analysis, integration, and mining of complex and diverse multi-parametric functional and genomics data sets. Effective written and verbal communication skills are also a must.
The scientist in this position will implement novel cutting edge cell biology and imaging technologies for the development of new disease relevant assays for screening, and be involved in all aspects of the implementation of small molecule screening, including assay design, development and optimization, high-throughput screening (HTS), data analysis, and follow-up studies in support of development of new pharmacological probes and target validation.
Legal working document is required for this position.
Interested applicants should send their curriculum vitae to Zhuyin.Li@NIH.gov
